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3,466 Possible Causes for Hyperpigmentation, Predisposition to UV Induced Malignancies, Vitiligo

  • Addison's Disease

    We herein report a case of Addison's disease caused by tuberculosis characterized by atypical hyperpigmentation, noted as exacerbation of the pigmentation of freckles and[ncbi.nlm.nih.gov] Patient with Addison’s disease on a background of vitiligo (face). Figure 2. Patient with Addison’s disease on a background of vitiligo (hands).[bjgp.org] Herein this case report, we focus on the subtle findings of diffuse hyperpigmentation and intermittent but repetitive "flu-like" symptoms in two patients to correctly identify[ncbi.nlm.nih.gov]

    Missing: Predisposition to UV Induced Malignancies
  • Pernicious Anemia

    Physical examination revealed hypotension and marked hyperpigmentation. Laboratory testing showed hyponatremia, hyperkaliemia and severe normocytic anemia.[ncbi.nlm.nih.gov] The case presented here is a woman who had a restoration of fertility after initiation of vitamin B12 treatment for vitiligo-associated pernicious anemia.[ncbi.nlm.nih.gov] Vitiligo is an acquired disease characterized by depigmentation of the skin due to destruction of melanocytes.[ncbi.nlm.nih.gov]

    Missing: Predisposition to UV Induced Malignancies
  • Rothmund Thomson Syndrome

    Rothmund-Thomson syndrome (OMIM #268400) is a severe autosomal recessive genodermatosis: characterised by growth retardation, hyperpigmentation and frequently accompanied[ncbi.nlm.nih.gov] Idiopathic Guttate Hypomelanosis Laugier-Hunziker Syndrome Lentigo Melasma Ocular Manifestations of Albinism Pigmented Lesions of the Eyelid Postinflammatory Hyperpigmentation Vitiligo[dokterairlangga.com] He was admitted when he was 26 months old because of short stature, dehydration, metabolic acidosis, hyperpigmentation, and typical skin lesions.[ncbi.nlm.nih.gov]

    Missing: Predisposition to UV Induced Malignancies
  • Localized Scleroderma

    Physical examination revealed several irregularly shaped, firm nodules with hyperpigmentation and induration on the trunk and upper arms (Panel A).[nejm.org] Figure 1 Vitiligo and morphea lesions on the lower limbs.[bmcresnotes.biomedcentral.com] […] with mineral-only formulations of sunscreen or with those that combine mineral and chemical sun filters, is emphasized in those with morphea because it will best prevent hyperpigmentation[sherberandrad.com]

    Missing: Predisposition to UV Induced Malignancies
  • Acute Hepatic Porphyria

    Secondary infections can cause areas of hypo- or hyperpigmentation or sclerodermatous changes and may result in the development of alopecia at sites of repeated skin damage[mayomedicallaboratories.com] […] manifestations Increased fragility of sun-exposed skin blistering and impaired healing ( blistering photosensitivity ) Healing results in scarring and milia formation Hypertrichosis Hyperpigmentation[amboss.com] Fragile, poorly healing skin with pruritus, hyperpigmentation and hypertrichosis are other features.[patient.info]

    Missing: Predisposition to UV Induced Malignancies
  • Tinea Versicolor

    Reddish-tan and fawn-colored hyperpigmentation in tinea versicolor of this type is not due to melanin pigment.[ncbi.nlm.nih.gov] Tinea versicolor usually appears on parts of the body distinct from the areas where vitiligo is normally found.[yeastinfection.org] Melasma is a facial hyperpigmentation resulting from the stimulation of melanocytes by endogenous or exogenous estrogen.[ncbi.nlm.nih.gov]

    Missing: Predisposition to UV Induced Malignancies
  • Variegate Porphyria

    It is characterized by skin hyperpigmentation and hypertrichosis, abdominal pain, tachycardia, hypertension and neuromuscular disturbances.[uniprot.org] […] may be limited; that CLINUVEL may never file an NDA for SCENESSE regulatory approval in the US; that the Company may not be able to access adequate capital to advance its vitiligo[porfiria.org] We present the case of two sisters showing cutaneous signs typical of PCT: blisters, photosensitivity, hyperpigmentation, hypertrichosis, cutaneous fragility, and no acute[porphyria.eu]

    Missing: Predisposition to UV Induced Malignancies
  • Cronkhite-Canada Syndrome

    A 62-year-old Malaysian woman presented with a constellation of skin signs including alopecia, hyperpigmentation and nail dystrophy.[ncbi.nlm.nih.gov] […] onychomadesis), alopecia (initially patchy, rapidly leading to complete hair loss), and hyperpigmentation (diffuse light-to-dark brownish macules and plaques, and patchy vitiligo[orpha.net] The disease is characterized by diffuse gastrointestinal polyposis, dystrophic changes of the fingernails, alopecia, cutaneous hyperpigmentation, diarrhea, weight loss, and[ncbi.nlm.nih.gov]

    Missing: Predisposition to UV Induced Malignancies
  • Autoimmune Polyendocrine Syndrome Type 2

    Hyperpigmentation over the palmer aspect of hands Hyperpigmentation over the foot hyperpigmentation over the face Physical examination on admission revealed, she was afebrile[ncbi.nlm.nih.gov] We communicate the case of a 61 year-old woman with vitiligo diagnosed with Addison’s disease and Hashimoto’s thyroiditis (Schmidt’s syndrome).[new.medigraphic.com] Our proband is a 12-year-old boy with Addison disease, insulin dependent diabetes mellitus (IDDM), and vitiligo.[ncbi.nlm.nih.gov]

    Missing: Predisposition to UV Induced Malignancies
  • Vitamin B12 Deficiency

    Hyperpigmentation as the first presentation of Vitamin B12 deficiency is rare.[ncbi.nlm.nih.gov] Skin Lesions, Vitiligo, And Sore Tongue Any change in the B12 content in the body can lead to skin problems like vitiligo, dermatitis, hyperpigmentation, or acne.[curejoy.com] For example, thyroid diseases, Addison's disease and vitiligo (a condition where white patches develop on skin).[patient.info]

    Missing: Predisposition to UV Induced Malignancies

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