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133 Possible Causes for Hyperpigmentation, Thick Facial Skin, Weight Gain

  • Corticotroph Pituitary Adenoma

    Over the ensuing years, the patient developed Nelson's syndrome with hyperpigmentation and markedly elevated ACTH levels.[ncbi.nlm.nih.gov] It is part of a group of diseases that cause Cushing’s syndrome, characterized by signs and symptoms that may include weight gain around the trunk and in the face, stretch[rarediseases.info.nih.gov] If the tumor develops after puberty, then the person has the following symptoms of acromegaly: thick, oily skin; coarse features with thick lips and a broad nose; prominent[drugs.com]

  • Acromegaly

    […] eyelids Increased body hair ( hypertrichosis ), excessive sweating ( hyperhidrosis ), and oily skin ( seborrhoea ) Increased number of skin tags and darkening of the skin ( hyperpigmentation[dermnetnz.org] We report the case of a 43 years old patient initially diagnosed with acromegaly accompanied by weight gain and acral enlargement.[ncbi.nlm.nih.gov] The facial aspect is characteristic and includes a widened and thickened nose, prominent cheekbones, forehead bulges, thick lips and marked facial lines.[orpha.net]

  • Adenoma

    […] cardiomegaly, heat intolerance, weight gain ACTH ( 20%) Cushing's disease : central obesity (moon facies, buffalo hump), thin skin with striae, hirsutism Nelson's syndrome : hyperpigmentation[en.wikibooks.org] PATIENT CONCERNS: A 5-month-old female infant with a history of overeating, hirsutism, and excessive weight gain for the previous 2 months was referred to the hospital.[ncbi.nlm.nih.gov] The features of acromegaly include characteristic coarsening of facial features (thick lips, exaggerated nasolabial folds, prominent supraorbital ridges, jaw enlargement),[eyewiki.aao.org]

  • Hypothyroidism

    Alopecia, sometimes associated with hyperpigmentation, often starts over points of wear. Occasionally, secondary pyoderma (which may produce pruritus) is observed.[web.archive.org] Symptoms include weight gain, constipation, dry skin, and sensitivity to the cold.[icd9data.com] […] expression, dementia or frank psychosis (myxedema madness) Dermatologic manifestations: Facial puffiness; myxedema; sparse, coarse and dry hair; coarse, dry, scaly and thick[merckmanuals.com]

  • Erythropoietic Protoporphyria

    Chronic UV (ultraviolet) exposure can lead to lichenification, postinflammatory hyperpigmentation, and scarring, particularly over the knuckles and on the nose [ 13, 23 ].[springerlink.com] Credit: Wikimedia Commons Harlequin ichthyosis is a severe genetic disorder that results in thick skin spotted with deep cracks.[cbsnews.com] After repetitive exposure, patients may present with lichenification, hypopigmentation, hyperpigmentation and scarring of the skin.EPP usually first presents in childhood,[en.wikipedia.org]

  • Xeroderma Pigmentosum

    Besides the basal cell carcinomas, the background hyperpigmentation and keratotic papules also cleared, and the skin texture improved.[ncbi.nlm.nih.gov] All Alb-Xpg mice displayed normal growth and weight gain, and none of them died prematurely ( Figure 5A ).[doi.org] […] that may be thick, crusty, or scaly) XP patients do not have a common facial appearance, with the exception of XP-CS patients.[forgottendiseases.org]

  • Achard Thiers Syndrome

    Complication due to anti-diabetic treatment was observed in 5 (1.66%) cases in form of photosensitivity (Sulfonylurea-induced), lipodystrophy and hyperpigmentation (with insulin[ijem.in] Pregnancy causes weight gain and increases levels of estogen and placental hormones, which antagonize insulin. some medications such as thiazide diuretics, adrenal corticosteroids[checkorphan.org] The hair itself is sometimes not particularly thick, but the roots are very large which cause a noticeable shadow under the skin.[anagentherapies.co.uk]

  • Pituitary Gland Carcinoma

    […] complex [ edit ] Carney complex (CNC), also known as LAMB syndrome [20] and NAME syndrome [20] is an autosomal dominant condition comprising myxomas of the heart and skin, hyperpigmentation[en.wikipedia.org] Too much of this hormone causes weight gain, particularly in the body’s trunk.[cancer.net] If the tumor develops after puberty, then the person has the following symptoms of acromegaly: thick, oily skin; coarse features with thick lips and a broad nose; prominent[drugs.com]

  • Actinic Lichen Planus

    ) Group 5: Localised hyperpigmentation of the face (eg periorbital hyperpigmentation, naevus of Ota) Group 6: Hyperpigmentation of the neck (eg poikiloderma of Civatte, acanthosis[pcds.org.uk] If you experience any of these symptoms call your doctor immediately: hives rash itching difficulty swallowing hoarseness unexplained weight gain shortness of breath or difficulty[medlineplus.gov] Labial skin and mucosa share histological characteristics identical respectively to facial skin and oral mucosa.[omicsonline.org]

  • Woodhouse Sakati Syndrome

    Some may present with hyperpigmentation , due to co-secretion with melanocyte-stimulating hormone (MSH), and possible penile enlargement.[maria-online.com] […] patches of thick, darker, velvety skin .[maria-online.com] Signs and symptoms of PCOS include irregular or no menstrual periods , heavy periods , excess body and facial hair , acne , pelvic pain, difficulty getting pregnant , and[maria-online.com]

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