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1,905 Possible Causes for Hyperpigmentation, Unable to Make a Fist

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  • Systemic Scleroderma

    […] severe type of systemic scleroderma with hyperpigmentation, especially male and older patients, and in unexposed portions of the female group without hyperpigmentation.[ncbi.nlm.nih.gov] Swelling and sclerosis reduce hand movements, so patients may be unable to make a fist, or to place the palmar surfaces together - the 'prayer sign'.[patient.co.uk] Abstract Skin hyperpigmentation and itching are characteristic findings in systemic sclerosis (SSC) patients.[ncbi.nlm.nih.gov]

  • Diffuse Scleroderma

    Skin can breakdown and discharge chalky material (calcium) Salt and pepper dyspigmentation ( hyperpigmentation and hypopigmentation ) Pruritus Rarer cutaneous features Morphoea[dermnetnz.org] Swelling and sclerosis reduce hand movements, so patients may be unable to make a fist, or to place the palmar surfaces together - the 'prayer sign'.[patient.co.uk] During the subsequent 6 months, the patient developed lower limb oedema, which progressed to the hands and face, coupled with generalized pain and hyperpigmentation of skin[doi.org]

  • Vitamin B12 Deficiency

    Hyperpigmentation as the first presentation of Vitamin B12 deficiency is rare.[ncbi.nlm.nih.gov] Localized hyperpigmentation is less frequently described, affecting palms, soles, and flexural areas.[ncbi.nlm.nih.gov] […] are presenting an interesting case of a 4 year old boy who was being treated for Vitamin B 12 deficiency on the basis of history of delayed milestone, abdominal pain and hyperpigmentation[ncbi.nlm.nih.gov]

    Missing: Unable to Make a Fist
  • Hemochromatosis

    External genital hyperpigmentation was seen in one third of patients, and one fifth had hyperpigmentation of flexural folds, scars, and nipple areolae.[emedicine.com] PubMed was used to search the following terms: hemochromatosis, hereditary, hyperpigmentation, hypopigmentation, keratosis, melanin, seborrheic, siderosis.[ncbi.nlm.nih.gov] Hyperpigmentation of the oral mucosa was found in 15-20% of patients.[emedicine.com]

    Missing: Unable to Make a Fist
  • Cronkhite-Canada Syndrome

    A 62-year-old Malaysian woman presented with a constellation of skin signs including alopecia, hyperpigmentation and nail dystrophy.[ncbi.nlm.nih.gov] The disease is characterized by diffuse gastrointestinal polyposis, dystrophic changes of the fingernails, alopecia, cutaneous hyperpigmentation, diarrhea, weight loss, and[ncbi.nlm.nih.gov] Cronkhite-Canada syndrome is characterized by generalized gastrointestinal polyps associated with hyperpigmentation, hair loss, and onycholysis.[ncbi.nlm.nih.gov]

    Missing: Unable to Make a Fist
  • Skin Cancer

    Prior to the laser sessions, these scars demonstrated hypopigmentation, hyperpigmentation, neovascularization, or diminished pore structures compared to the surrounding skin[ncbi.nlm.nih.gov] Hyperpigmentation has been treated with dermabrasion and laser resurfacing. Graft Failure Skin grafting may be unsuccessful for numerous reasons.[web.archive.org]

    Missing: Unable to Make a Fist
  • Adenoma

    […] cardiomegaly, heat intolerance, weight gain ACTH ( 20%) Cushing's disease : central obesity (moon facies, buffalo hump), thin skin with striae, hirsutism Nelson's syndrome : hyperpigmentation[en.wikibooks.org]

    Missing: Unable to Make a Fist
  • Hyperthyroidism

    Reactive hyperpigmentation of the skin and mucous membranes may be found in Addison's disease and hyperthyroidism.[ncbi.nlm.nih.gov]

    Missing: Unable to Make a Fist
  • Acanthosis Nigricans

    He was referred to our polyclinic by endocrinologist because of progressive hyperpigmentation marked on his face and oral mucosa.[ncbi.nlm.nih.gov] This is part II of a two-part article on hyperpigmentation in adults.[aafp.org] It is characterized by proliferation of keratinocytes resulting in papillomatous change and hyperpigmentation of the skin and multiple confluent warty or verrucous lesions[ncbi.nlm.nih.gov]

    Missing: Unable to Make a Fist
  • Adrenal Insufficiency

    PATIENT AND METHODS: The patient was born with hyperpigmentation, micropenis, penoscrotal hypospadias, and mild cryptorchidism.[ncbi.nlm.nih.gov] This situation may be associated with symptoms suggestive of chronic adrenal insufficiency such as hyperpigmentation, salt craving, and association with autoimmune diseases[ncbi.nlm.nih.gov] Addison disease was identified due to hyperpigmentation of lips and gums present from early childhood.[ncbi.nlm.nih.gov]

    Missing: Unable to Make a Fist

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