Create issue ticket

23 Possible Causes for Hyperpigmentation in Flexure Areas

  • Vitamin B12 Deficiency

    Localized hyperpigmentation is less frequently described, affecting palms, soles, and flexural areas.[ncbi.nlm.nih.gov] Cases of generalized hyperpigmentation associated with vitamin B12 deficiency have rarely been reported.[ncbi.nlm.nih.gov] We report a rare case of reversible melasma-like cutaneous hyperpigmentation associated with pernicious anemia and discuss the possible mechanisms of this association.[ncbi.nlm.nih.gov]

  • Acanthosis Nigricans

    It mainly affects flexural areas.[ncbi.nlm.nih.gov] No similar changes were observed in flexural areas. Personal and family history was not suggestive of diabetes mellitus, thyroid dysfunction and tuberculosis.[ijdvl.com] Acanthosis nigricans (OMIM ID % 100600) is a dermatosis characterized by velvety hyperpigmentation, skin thickening, and papillomatosis.[ncbi.nlm.nih.gov]

  • Submammary Abscess

    Clinical manifestations primarily involve the flexural areas in a symmetric fashion (groin, axillae, lateral neck, submammary region, and perineum).[medical-dictionary.thefreedictionary.com] The disease initiates with symmetric skin hyperpigmentation in the axillary and inguinal folds, submammary region, around the mammilla, umbilical, and ano-genital regions.[medical-dictionary.thefreedictionary.com]

  • ANE Syndrome

    Elife. 2016 Apr 14;5. pii: e16381. doi: 10.7554/eLife.16381. Author information 1 Department of Genetics, Yale University School of Medicine, New Haven, United States. 2 Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park,[…][ncbi.nlm.nih.gov]

  • Crouzon Syndrome

    The acanthosis nigricans is characterized by verrucous hyperplasia and hypertrophy of the skin with hyperpigmentation, especially in flexural areas.[saintfrancis.com]

  • Lichen Planus

    LP is typically seen as pruritic, faintly erythematous to violaceous, flat-topped, polygonal papules distributed mainly over the flexural areas of wrists, arms, and legs.[doi.org] The coalescence of individual papules into plaques, the presence of fine white lines on the surface of skin lesions, and the hyperpigmentation after resolution are its clinical[doi.org]

  • Generalized Lipodystrophy

    […] and thickening of flexural areas and generalized hypertrichosis since birth.[ijpd.in] […] scalp hair and hypertrichosis and lipodystrophy of cheeks Click here to view Case 2 An 11-year-old male, born out of second degree consanguineous marriage, presented with hyperpigmentation[ijpd.in]

  • Acquired Generalized Lipodystrophy

    […] and thickening of flexural areas and generalized hypertrichosis since birth.[ijpd.in] […] scalp hair and hypertrichosis and lipodystrophy of cheeks Click here to view Case 2 An 11-year-old male, born out of second degree consanguineous marriage, presented with hyperpigmentation[ijpd.in]

  • Crouzon Syndrome-Acanthosis Nigricans Syndrome

    The acanthosis nigricans is characterized by verrucous hyperplasia and hypertrophy of the skin with hyperpigmentation, especially in flexural areas.[saintfrancis.com]

  • Costello Syndrome

    […] of on the neck and flexural areas and sometimes on posterior earlobes, these can be verrucous in older individuals.[dermnetnz.org] Pigmentation abnormalities Generalised hyperpigmentation of skin is seen in a third of the affected individuals; acanthosis nigricans is reported in a third with velvety plaques[dermnetnz.org]

Further symptoms