Possible Causes for hyperpigmented patches Actinic Keratosis Eryfotona AK-NMSC (ISDIN Spain) is a film-forming medical device in cream or fluid formulation containing the DNA-repair enzyme photolyase and high-protection UV filters in liposomes (repairsomes) indicated in the treatment of cancerization field in patients with actinic keratosis (AK) or non-melanoma skin cancer[…] [ncbi.nlm.nih.gov] Contact Dermatitis Dear Editor, Nickel is a ubiquitous allergen and an important cause of allergic contact dermatitis (ACD). Sensitized patients generally develop a localized eruption after cutaneous exposure to nickel, characterized by erythema, vesicles, eczematous plaques, and itching. Nickel is frequently found in several everyday[…] [ncbi.nlm.nih.gov] Vitiligo […] that may be surrounded by a hyperpigmented border Vitiligo causes white patches on your skin. [icd9data.com] Usually progressive, chronic pigmentary anomaly of the skin manifested by depigmented white patches that may be surrounded by a hyperpigmented border. [icd10data.com] Differential diagnosis includes postinflammatory hypopigmentation, piebaldism (a rare autosomal dominant disorder in which depigmented patches surrounded by hyperpigmented [msdmanuals.com] Non-Hodgkin Lymphoma We report a rare case of non-Hodgkin lymphoma presented as an ileocecal mass. The patient was a 77-year-old man with history of symptoms of partial bowel obstruction, intermittent right iliac fossa pain, loss of weight, vomiting and fatigue. Clinical signs included moderate abdominal tenderness with a palpable mass in[…] [ncbi.nlm.nih.gov] Neurofibromatosis It is characterized clinically by cutaneous and subcutaneous tumors with patches of hyperpigmentation. [icd9data.com] The hyperpigmented skin areas, are present from birth and found anywhere on the body surface. They can vary markedly in size and color. [icd9data.com] Dyskeratosis Congenita Upon initial presentation to clinic at age seven-years-old, the patient was noted to have scattered reticulate hyperpigmented patches on the trunk and anterior lower extremities [ijcasereportsandimages.com] The predominant cutaneous finding is hypopigmented or hyperpigmented atrophic macules and patches with telangiectasia in a mottled or reticular pattern over sun-exposed and [ibimapublishing.com] Mycosis Fungoides An intractable hyperpigmented patch should raise the clinical suspicion of mycosis fungoides with sequential skin biopsy. [ncbi.nlm.nih.gov] D, Large asymptomatic hyperpigmented patch with numerous overlying comedones on the left chest. [pediatrics.aappublications.org] patches on the trunk and right leg with progression over this half a year. [ncbi.nlm.nih.gov] Kaposi Sarcoma Patch-stage Kaposi sarcoma, manifesting as hyperpigmented patches on the thigh. Figure 4. Violaceous and hyperpigmented patches of Kaposi sarcoma. Figure 5. [infectiousdiseaseadvisor.com] These include: Lichenoid tissue reactions: lichen planus and lichenoid-type drug eruptions can present with hyperpigmented to violaceous patches, papules, or plaques on the [infectiousdiseaseadvisor.com] (Figure 1, Figure 2), patches (Figure 3, Figure 4, Figure 5), and/or plaques. [infectiousdiseaseadvisor.com] McCune-Albright Syndrome Cutaneous examination at age 11 years demonstrated a small café au lait patch on the right lateral chest ( Figure 1 A) and hyperpigmented macules on the lower lip ( Figure [jamanetwork.com] Dermatologic examination revealed a medium-sized café au lait patch on the left temple and the left sacrum and a smaller patch on the right lower abdomen. [jamanetwork.com] Several hyperpigmented macules were present on bilateral buccal mucosae and vermilion lips, which had developed at age 7 years ( Figure 2 B). [jamanetwork.com] Xeroderma Pigmentosum A female patient with xeroderma pigmentosum and multiple basal cell carcinomas was treated with a hedgehog pathway inhibitor (vismodegib), which successfully treated the majority of her basal cell carcinomas while preventing the appearance of new lesions. The sum diameter of lesions showed a 61% decrease after 16.5[…] [ncbi.nlm.nih.gov] Linear Atrophoderma of Moulin It is generally characterized by oval or round atrophic, nonsclerotic, hyperpigmented patches following Blaschko's lines. [ncbi.nlm.nih.gov] Skin biopsy was repeated from normal skin ( Fig 2, A ) and from the hyperpigmented patch ( Fig 2, B ) on the right arm. [ncbi.nlm.nih.gov] Skin biopsy was repeated from normal skin (Fig 2, A) and from the hyperpigmented patch (Fig 2, B) on the right arm. [mafiadoc.com] Kwashiorkor Two infants with a florid erythematous rash and generalised oedema, hypoalbuminaemia, and anaemia were found to have cystic fibrosis. This rare presentation is associated with false negative sweat tests, delays in diagnosis, and a considerable mortality. It is proposed that this presentation represents a[…] [ncbi.nlm.nih.gov] Winchester Syndrome Phenotypic heterogeneity of cutaneous features are also reported to date of diffusely thickened leathery skin, hypertrichosis, patches of hyperpigmented, hypertrichotic leathery [ncbi.nlm.nih.gov] patches No No Yes Yes Yes Yes Yes No No No Skin nodules No No Yes No No No No Yes No No Corneal opacity Yes Yes Yes Yes Yes No No No No Yes d Gum hypertrophy Yes Yes Yes [emedicine.medscape.com] patches No No Yes Yes Yes Yes Yes No No No Skin nodules No No Yes No No No No Yes No No Corneal opacity Yes Yes Yes Yes Yes No No No No Yesd Gum hypertrophy Yes Yes Yes Yes [emedicine.medscape.com] Arsenical Keratosis A frequent dermatologic sign of chronic arsenic exposure is cutaneous melanosis of the trunk, which is characterized by hyperpigmented patches often affecting the nipples [ncbi.nlm.nih.gov] Within these hyperpigmented patches are often seen small areas of hypopigmentation, resembling “raindrops in the dust.” Diffuse alopecia of the scalp may be present. [dermaamin.com] Diffuse hyperpigmented patches in the intertriginous, genital, and acral areas may be an early sign of chronic arsenic toxicity. [emedicine.medscape.com] Juvenile Nevus There are only 12 reports of Spitz naevi arising on hyperpigmented patches: 2-12 we describe here three further cases, all on the arms of children, seen in our department [onlinelibrary.wiley.com] Agminate Spitz nevi arising on hyperpigmented patches. Clin Exp Dermatol. 1994; 19(6):483-486. 9. Akasaka T, Imamura Y, Kon S. [sochiderm.org] PMID 19561450 Agminate Spitz naevi arising on hyperpigmented patches. Herd RM, Allan SM, Biddlestone L, Buxton PK, Mclaran KM. Clin Exp Dermatol. 1994 Nov;19(6):483-6. [atlasgeneticsoncology.org] Fixed Eruption patches as a result of systemic exposure to a drug. [jcsjournal.org] The healing process occurs spontaneously after few days to weeks after the offending drug is discontinued and may leave a hyperpigmented patch. [ijhas.in] Lesions may persist from days to weeks and then fade slowly to residual oval hyperpigmented patches. [emedicine.medscape.com] Acanthosis Nigricans patches, which thicken with a velvety texture Many small, papillomatous lesions develop within affected areas Malignant AN Itch / irritation is common Lesions arise more [pcds.org.uk] It presents as an asymptomatic hyperpigmented patch which is indistinguishable from dirt. [dovepress.com] The skin changes appear slowly, sometimes over months or years as hyperpigmented macules and patches that progress to palpable plaques. [lucianoschiazza.it] Mesoaxial Synostotic Syndactyly with Phalangeal Reduction Skin graft can be observed as hyperpigmented patches within web space. Some parts of full-thickness skin graft also were noted to be hair-bearing. [emedicine.medscape.com] Extramammary Paget Disease Symptoms of Extramammary Paget's Disease [7] Skin transient rash itchiness erythematous well-demarcated, non-resolving, eczematous plaque hyperpigmented patches scaly lump [en.wikipedia.org] Balanitis The other one had a great improvement of the lesion, but a hyperpigmented patch persisted on the glans. [ncbi.nlm.nih.gov] Atopic Dermatitis In particular, the yeast M furfur commonly affects the head neck and trunk17 with red, hypopigmented (white), or hyperpigmented (light to medium brown) patches that may have [journals.lww.com] Eosinophilic Pustular Folliculitis patches Various images Microscopic (histologic) description Eosinophilic infiltration of hair follicle; follicular epithelium is spongiotic, adjacent dermis has lymphocytic [pathologyoutlines.com] Widespread hyperpigmented patches on the back and the arms in a patient with eosinophilic pustular folliculitis. Courtesy of Professor T. [emedicine.medscape.com] (Ofuji disease) Immunosuppression / HIV associated Infancy associated Clinically resembles acne No known cause Clinical images Images hosted on other servers: Widespread hyperpigmented [pathologyoutlines.com] Folliculotropic Mycosis Fungoides D, Large asymptomatic hyperpigmented patch with numerous overlying comedones on the left chest. [pediatrics.aappublications.org] Clinical variations include annular and hyperpigmented patches, plaques, hyperkeratotic lesions, vesicles, pustules, dyshidrotic lesions, verrucous changes, psoriasiform plaques [mussenhealth.us] patch with numerous overlying comedones on his left chest ( Fig 1 ). [pediatrics.aappublications.org] Pityriasis Circinata Hyperpigmented patches on the trunk of a Nigerian woman. Pityriasis rotunda (PR). [actasdermo.org] Hyperpigmented patches on the trunk of a Nigerian woman. Arch Dermatol 2008;144:1509 [PubMed] 3. Mafong EA. Pityriasis rotunda. Dermatol Online J 2002;8:15 [PubMed] 4. [escholarship.org] patch. 3,4 Collarettes of scale decorate the inner aspect of the margin of the annulus. [derm101.com] Segmental Odontomaxillary Dysplasia We report a 16-month-old black boy with a hyperpigmented patch on his right shoulder and upper pectoral area that extended down his arm. [scinapse.io] Case Report A 14-year-old adolescent boy presented to the dermatology clinic at our institution for evaluation of a hyperpigmented hairy patch on the right side of the face [mdedge.com] patch over the groin area. [e-ijd.org] Diabetes Mellitus T2DM patients are typically overweight/obese and present with signs of insulin resistance, including acanthosis nigricans, which are hyperpigmented, velvety patches on the [ncbi.nlm.nih.gov] Erythema Elevatum Diutinum patches on the lower extremities. [ncbi.nlm.nih.gov] patches with loss of collagen in the dermis, and fibrosis. 5-7 They are generally asymptomatic and soft, secondary to edema and tissue destruction; however, they may be tender [jddonline.com] Red-brown indurated nodules over extensor joint surfaces with superficial scale Periumbilical reticulate hyperpigmented patch LABORATORY TESTS: Pertinent laboratory findings [aocd-grandrounds.org] Syndactyly Skin graft can be observed as hyperpigmented patches within web space. Some parts of full-thickness skin graft also were noted to be hair-bearing. [emedicine.com] Penile Intraepithelial Neoplasia Dermoscopy of the eroded plaque (A) and hyperpigmented patch (B) shown in Fig 1. [docksci.com] Telangiectasia Macularis Eruptiva Perstans Case 1 A 73-year-old female presented with hyperpigmented patches on her thighs, knees, and ankles/dorsal feet. She had no systemic symptoms. [bloodjournal.org] Berloque Dermatitis Hyperpigmented patch with streaking. Treatment may require observation only. [icls.ca] Treatment may involve patch testing. Post-Inflammatory Hyperpigmentation Diffused, hyperpigmented patches. Treatment may involve Q-Switch YAG laser. [icls.ca]
