Hyperpigmented Skin Lesions: Causes & Reasons

Possible Causes for Hyperpigmented Skin Lesions

Immunophenotyping of subpopulations of immunocompetent cells in a biopsy of an atrophic hyperpigmented skin lesion revealed sparsity and unusual distribution of epidermal [ncbi.nlm.nih.gov]

Figure 1: Hyperpigmented and hypopigmented skin lesions on patient's face and forearm Figure 2: (a) Preoperative picture showing right eye lower eyelid ectropion and symblepharon [journals.lww.com]

Figure 1: Hyperpigmented and hypopigmented skin lesions on patient's face and forearm Click here to view Figure 2: (a) Preoperative picture showing right eye lower eyelid [ijo.in]

Acral Lentiginous Melanoma

Twenty-eight days after discharge she was in good health and clinical recovery was complete except for hyperpigmented cutaneous lesions. [archbronconeumol.org]

[…] her hospital stay, cultures were ordered on the following samples: urine, stool, throat swab (bacteriology and virology), mouth ulcer swab (virology), conjunctival swab, skin [archbronconeumol.org]

Malignant Melanoma in Childhood

Cancer. 1993 Jun 15;71(12):4096-103. Abstract Six cases of malignant melanoma in children 14 years of age and younger are reported. The six cases were diagnosed among 850,000 consecutive skin biopsy specimens and consultation slides examined within a 32-year period. This series included an infant born with[…] [ncbi.nlm.nih.gov]

Linear Atrophoderma of Moulin

The diagnosis is clinical, characterized by acquired unilateral hyperpigmented, depressed band-like skin lesions following Blaschko's lines. [ncbi.nlm.nih.gov]

Observations: Four patients (2 men, 2 women) had a history of unilateral band-like skin lesions located on the lower legs (50%) or the trunk (50%). [karger.com]

Physical examination showed atrophic and hyperpigmented skin lesions along Blaschko's lines, which appeared during childhood in 3 cases and at the age of 20 in the last case [ncbi.nlm.nih.gov]

Dyschromatosis Universalis Hereditaria Type 1

Case one was a 30-year-old male patient who presented with asymptomatic multiple hypopigmented, and hyperpigmented skin lesions all over the body [Figure 1] a and b since [e-ijd.org]

Case report A 21-year-old female with a history of progressive asymptomatic hypo- and hyperpigmented skin lesions distributed over her face, neck, upper, and lower extremities [dovepress.com]

Our patient’s mother had similar lesions. Skin biopsy from a hyperpigmented macule over the dorsum of hand showed increased melanin in the basal layers. [indianpediatrics.net]

Autosomal Recessive Spastic Paraplegia Type 23

skin lesions. [ghr.nlm.nih.gov]

[…] autosomal recessive form characterized by childhood-onset of gait difficulties and pigmentary abnormalities, including premature graying of the hair and vitiligo-like or hyperpigmented [ghr.nlm.nih.gov]

Panostotic Fibrous Dysplasia

When associated to endocrinopathies and/or hyperpigmented skin lesions we speak about McCune Albright syndrome. [scienceopen.com]

Dyschromatosis Universalis Hereditaria

Case one was a 30-year-old male patient who presented with asymptomatic multiple hypopigmented, and hyperpigmented skin lesions all over the body [Figure 1] a and b since [e-ijd.org]

Case report A 21-year-old female with a history of progressive asymptomatic hypo- and hyperpigmented skin lesions distributed over her face, neck, upper, and lower extremities [dovepress.com]

DUH is characterized by mixtures of hyperpigmented- and hypopigmented macules all over the body. Skin lesions are usually present in the first years of life. [sparrho.com]

Dowling-Degos Disease Type 3

Case 2A sixteen year old female (daughter of case one) presented with hyperpigmented skin lesions over the face, chest and back for two years. [ijdvl.com]

The skin lesions first appeared 22 years ago. They were mostly asymptomatic, so he did not seek any treatment. [karger.com]

Case Report A 37-year-old Thai man with an underlying disease of hepatitis C cirrhosis presented with slowly progressive hyperpigmented comedone-like papules on the face, [karger.com]

Pityriasis Rotunda

Lesions are usually darker than surrounding skin (hyperpigmented) in patients with dark skin and lighter (hypopigmented) in patients with light skin. [dermnetnz.org]

Clinical examination showed hyperpigmented scaly, circular, fine plaques over the hips and limbs with sharp demarcation between the lesional area and the normal surrounding [odermatol.com]

Several lesions are usually present, ranging from 4 to 80 Commonly situated on the buttocks, thighs, abdomen, trunk, and upper and lower extremities Once lesions develop they [dermnetnz.org]

Endemic Kaposi Sarcoma

Lymph node involvement was present in 50%, hyperpigmented skin lesions in 45%, and woody edema in 40%. [scite.ai]

Hyperpigmented skin lesions were present in around half of both cohorts (P = 0.21). [infectagentscancer.biomedcentral.com]

The most common clinical site of endemic KS involvement was lymph node (50%) followed by hyperpigmented skin lesions (45%) and woody edema (40%, Table 1). [infectagentscancer.biomedcentral.com]

Bloch Sulzberger Syndrome

[…] verrucous skin lesions. [medical-dictionary.thefreedictionary.com]

Farlex Partner Medical Dictionary © Farlex 2012 Bloch-Sulz·ber·ger syn·drome (blok-sults'ber-ger sin'drōm) Variously patterned hyperpigmented lesions after development of [medical-dictionary.thefreedictionary.com]

This explanation is supported by reports showing that the first stage skin lesions are absent in 5%–10% of cases.6 The third stage blaschkoid hyperpigmented linear skin lesions [dovepress.com]

Familial Atrophia Maculosa Varioliformis Cutis

On inspection, there were bilateral, multiple, discrete, both skin-colored and hyperpigmented, atrophic varioliform scar lesions on the above sites [Figure - 1] and [Figure [ijdvl.com]

[…] pigmented, round, scar-mark like atrophic lesions present on face, neck, upper chest, back, forearms and arms since last 18 years with gradual increase in the number of lesions [ijdvl.com]

Reticulate Acropigmentation of Kitamura

Case report A 21-year-old female with a history of progressive asymptomatic hypo- and hyperpigmented skin lesions distributed over her face, neck, upper, and lower extremities [dovepress.com]

Our patient’s mother had similar lesions. Skin biopsy from a hyperpigmented macule over the dorsum of hand showed increased melanin in the basal layers. [indianpediatrics.net]

A 25-year-old male presented with asymptomatic dark-colored lesions on his hands and feet with light-colored skin lesions involving the trunk since three years. [ncbi.nlm.nih.gov]

Dyschromatosis Symmetrica Hereditaria

Case report A 21-year-old female with a history of progressive asymptomatic hypo- and hyperpigmented skin lesions distributed over her face, neck, upper, and lower extremities [dovepress.com]

[…] dominant manner In this disorder, mainly the arms and legs are marked by flat skin lesions (called macules) that may be hyperpigmented and hypopigmented; the skin patches [dovemed.com]

The skin lesions were characterized by a mixture of hyperpigmented and hypopigmented macules and were localized on the back of the feet of three patients (two male brothers [ncbi.nlm.nih.gov]

Erythema ab Igne

Introduction Chronic exposure to heat and infrared radiation may result in reticulated erythematous and hyperpigmented skin lesions known as erythema ab igne. [cureus.com]

AB - Erythema ab igne (EAI) is a persistent chronic skin condition that is characterized by reticulated macular hyperpigmented lesions caused by repeated exposure to infrared [koreauniv.pure.elsevier.com]

[…] livedo reticularis-like lesions and the distribution of skin involvement should mirror the heat source in question. 4 The pigmentation may persist for severe months or also [academic.oup.com]

Mixed Germ Cell Central Nervous System Tumor

lesions, which is developed due to the use of bleomycin. [revistaschilenas.uchile.cl]

Clinically it occurs as erythematous or hyperpigmented maculae of linear disposition with flagellar pattern, in trunk and/or upper extremities. [revistaschilenas.uchile.cl]

//www.revistachilenadepediatria.cl/index.php/rchped/article/view/522 dc.description Introduction: Flagellated dermatitis is an infrequent pathology, with characteristic skin [revistaschilenas.uchile.cl]

Familial Progressive Hyperpigmentation with or without Hypopigmentation

lesions of both patients, compared to control healthy skin. [moh-it.pure.elsevier.com]

[…] pigmentation anomaly disorder characterized by progressive, diffuse, partly blotchy, hyperpigmented lesions that are intermixed with multiple café-au-lait spots, hypopigmented [orpha.net]

In the differential diagnosis, one should consider Dowling–Degos disease, a rare but harmless genetic condition that can cause hyperpigmented skin of the axillae and groin [medicinetoday.com.au]

Familial Spinal Neurofibromatosis

Many other hyperpigmented skin lesions are commonly misdiagnosed as CAL, such as the lesion in Figure 2D. Figure 2. [scielo.br]

Noonan Syndrome-Like Disorder with Juvenile Myelomonocytic Leukemia

skin lesions, cryptorchidism, cardiopathy, neurological lesions, developmental delay, postnatal growth retardation, and autoimmune phenomena. [rasopathiesnet.org]

Besides JMML predisposition, germline CBL mutation defines a new dominant genetic condition with a markedly variable phenotype combining dysmorphic features, hyperpigmented [rasopathiesnet.org]

Lentigines

Spots & lentigines belong to the same category of hyperpigmented skin lesions. [cosmeticdermamedicine.gr]

lesion characterized by hyperpigmented macules. [caspjim.com]

[…] definition Lentigines are impalpable hyperpigmented lesions that display an increased number of melanocytes in the basal layer of the epidermis. [dermis.net]

McCune-Albright Syndrome

Patients with McCune-Albright syndrome (MAS), characterized primarily by hyperpigmented skin lesions, precocious puberty, and fibrous dyslasia of bone, carry postzygotic heterozygous [ncbi.nlm.nih.gov]

skin lesions with characteristic features, including jagged "coast of Maine" borders and tendency occur along the midline of the body. [en.wikipedia.org]

[…] endocrinologist Fuller Albright.[2][3][4] Signs and symptoms[edit] McCune–Albright syndrome is suspected when two or more of the following features are present: Fibrous dysplasia Hyperpigmented [en.wikipedia.org]

Ring Chromosome 7

skin lesions and malignant melanoma. ( 1415332 ) DeLozier-Blanchet C.D....Vollenweider S. 1992 26 Severe anomalies associated with ring chromosome 7. ( 1746606 ) Biesecker [malacards.org]

skin lesions and malignant melanoma. ( 1415332 ) DeLozier-Blanchet C.D....Vollenweider S. 1992 25 Severe anomalies associated with ring chromosome 7. ( 1746606 ) Biesecker [malacards.org]

Okada S. 1993 23 Cutaneous findings in ring chromosome 7 syndrome. ( 8428052 ) 1993 24 Melanoma associated with ring chromosome 7. ( 8428043 ) 1993 25 Ring chromosome 7, hyperpigmented [malacards.org]

Dermatillomania

Skin exam showed multiple hyperkeratotic hyperpigmented lesions, mainly on posterior neck and forearms. [qims.amegroups.com]

Figure 1 Multiple hyperkeratotic hyperpigmented lesions, on posterior neck, back and legs (A,B,C). [qims.amegroups.com]

The patient’s condition improved significantly with psychotherapy, and his skin lesions also improved. [qims.amegroups.com]

Familial Normophosphatemic Tumoral Calcinosis

Gene SAMD9 gene, 7q21.2 (OMIM gene/locus number #610456 ) Phenotype Reddish to hyperpigmented skin lesions, soft tissue masses at the extremities, calcified ulcerating nodules [iofbonehealth.org]

Mononeuropathy Multiplex

We report a case of 34-year-old male who had multiple joint pains for 10 years, hyperpigmented skin lesions on face with photosensitivity for 4 years, oral erosions for 2 [escholarship.org]

Acromelanosis

Case one was a 30-year-old male patient who presented with asymptomatic multiple hypopigmented, and hyperpigmented skin lesions all over the body [Figure 1] a and b since [e-ijd.org]

[…] though transplantation of thin split-thickness skin autografts for hypopigmented lesions and laser therapy for hyperpigmented macules especially on the face has been tried [pigmentinternational.com]

[…] or hypopigmented lesions respectively. [ijdvl.com]

GM1 Gangliosidosis Type 1

skin lesions were apparent at birth and had not changed in number, position or size. [e-ijd.org]

Mongolian spots on ventral surface of the trunk Figure- 2: Numerous, diffuse ecchymoses and Mongolian spots on dorsal surface of the trunk Figure -3: Coarse facial features The hyperpigmented [medresearch.in]

[…] spots on ventral surface of the trunk Click here to view Figure 2: Numerous, diffuse ecchymoses and Mongolian spots on dorsal surface of the trunk Click here to view The hyperpigmented [e-ijd.org]

Familial Atrial Myxoma

On examination, the patient had skin phototype 2 (i.e., skin that usually burns and sometimes tans), with various hyperpigmented cutaneous lesions,. .. Offer Amir, M.D. [nejm.org]

Seven years earlier, a pigmented nevus (0.7 by 0.4 cm) had been excised from his upper back and diagnosed as malignant melanoma, with invasion of the skin to the level of [nejm.org]

Acrochordon

Topic Resources Skin tags are common, soft, small, flesh-colored or hyperpigmented, pedunculated lesions; there are usually multiple lesions, typically on the neck, axilla [msdmanuals.com]

Clinically, they appear as soft, skin coloured or hyperpigmented, usually pedunculated lesions often occurring on the neck, and major flexures of the body. [ijdvl.com]

Skin tags are usually asymptomatic but may be irritating. [msdmanuals.com]