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525 Possible Causes for Hyperreflexia, Hyporeflexia, Peripheral Neuropathy

  • Friedreich Ataxia

    We report two patients with delayed-onset, hyperreflexia and gradually progressive disease.[ncbi.nlm.nih.gov] neuropathy resembling Friedreich’s ataxia, and markedly reduced plasma levels of vitamin E.[medical-dictionary.thefreedictionary.com] His examination was significant for spastic gait, hyperreflexia, and sensory neuropathy. Genetic testing revealed a compound heterozygous mutation in the FXN gene.[ncbi.nlm.nih.gov]

  • Pernicious Anemia

    Some people with pernicious anemia may also become extremely irritable or depressed and, in some rare cases, even experience paranoia (megaloblastic madness).[rarediseases.org] Cobalamin deficiency–related neurological impairment can vary in clinical presentation, including acute combined system degeneration, peripheral neuropathy, and psychosis.[emedicine.medscape.com] Pernicious Anemia Macrocytic anemia, glossitis, peripheral neuropathy, weakness, hyperreflexia, ataxia, and other neurological manifestations characterize classical vitamin[clinlabnavigator.com]

  • Pelizaeus-Merzbacher Disease

    Last neurological examination in 1999 showed no nystagmus anymore, but extremely dystrophic limbs, truncal deformation, due to severe scoliosis, tetraplegia with hyperreflexia[ncbi.nlm.nih.gov] The result of mutations is abnormal myelination - hypomyelination and dysmyelination of cerebral white matter, and in some form of the disease hypomyelinating peripheral neuropathy[ncbi.nlm.nih.gov] Two brothers with profound neonatal hypotonia and hyporeflexia and electrodiagnostic testing consistent with lower motor neuron pathology were found to have a leukodystrophy[ncbi.nlm.nih.gov]

  • Cervical Myelopathy

    Gait dysfunction associated with spasticity and hyperreflexia is a primary symptom in patients with compression of cervical spinal cord.[ncbi.nlm.nih.gov] neuropathies.[ncbi.nlm.nih.gov] Those with diabetes also had a significantly higher incidence of hyporeflexia and a higher incidence of a positive Babinski sign, but there was no difference in the appearance[ncbi.nlm.nih.gov]

  • Transverse Myelitis

    Examination reveals moderate paraparesis with hyperreflexia, a left extensor plantar response, impaired vibratory and proprioceptive sensation, and a sensory level at T6.[nejm.org] neuropathy, and white matter disease in children with CD, but this risk was lower than in adults.[pediatrics.aappublications.org] […] nonspecific viral illness) • ATM, the onset of spinal cord dysfunction usually progress in 4 hours to 21 days, the patient's signs usually plateau and evolve toward spasticity/hyperreflexia[slideshare.net]

  • Myelopathy

    Clinical hyperreflexia was tested at the MCP joint, using a six-axis load cell.[ncbi.nlm.nih.gov] VM is often associated with AIDS dementia complex and peripheral neuropathy. In such cases, patients have cognitive decline and distal limb pain and numbness.[emedicine.medscape.com] Clinical features vary depending on the level of the lesion and include local pain , stiffness, and impaired sensation, hypotonia , and hyporeflexia at the level of the lesion[amboss.com]

  • Phenytoin

    Severe toxicity is typified by tremor, hyperreflexia, lethargy, and coma.[mayomedicallaboratories.com] This report documents an unusual case of distal symmetrical peripheral neuropathy (DSPN) in an otherwise healthy patient without diabetes mellitus (DM) presenting to a podiatric[ncbi.nlm.nih.gov] […] perversion (including metallic taste), taste loss, reflexes decreased, reflexes increased, migraine , slurred speech, dysarthria, intracranial hypertension , hyperesthesia, hyporeflexia[drugs.com]

  • Hereditary Sensory Neuropathy

    A variable degree of increased muscle tone was observed in younger patients, whilst some older affected individuals only presented with hyperreflexia of patellar tendon reflexes[ncbi.nlm.nih.gov] Types of Peripheral Neuropathy There are several different kinds of peripheral neuropathies that stem from a variety of causes.[webmd.com] Examination showed a complete lack of pain sensation throughout her body and hyporeflexia.[ecommons.aku.edu]

  • Hereditary Spastic Paraplegia

    Orthostatic intolerance, urinary symptoms, hyperreflexia in the biceps and knee jerk, and decreased proprioception in both limbs were observed on neurological examinations[ncbi.nlm.nih.gov] This study adds to the evidence associating the known occurrence of mild peripheral neuropathy in the adult onset SPG10 type of AD-HSP.[ncbi.nlm.nih.gov] Hyperreflexia, extensor plantar response and increased muscle tone are the recognized UMN signs where as the weakness, muscle wasting, hyporeflexia, muscle cramps, and fasciculations[explainmedicine.com]

  • Spinal Cord Compression

    Physical examination revealed hyperreflexia and a T11 sensory level. MRI revealed a pseudomeningocele compressing the thoracic spinal cord.[ncbi.nlm.nih.gov] The symptoms of cervical myelopathy can be similar to the symptoms of peripheral neuropathy, cubital tunnel syndrome, or carpal tunnel syndrome.[uncmedicalcenter.org] […] brisk reflexes and spasticity At the level of compression there are usually lower motor neuron signs (due to compression of the nerve roots as well as spinal cord) i.e. hyporeflexia[dundeemedstudentnotes.wordpress.com]

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