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532 Possible Causes for Hyperreflexia, Muscle Hypotonia

  • Leigh's Disease

    Abstract A 4 1/2-month-old girl suffered from psychomotor retardation, generalized hypotonia, poor feeding, hyperreflexia, nystagmus, optical atrophy and choreoathetosis from[ncbi.nlm.nih.gov] Abstract An 11-month-old boy with muscle hypotonia and neurologic deteriorations had lactic acidosis, pyruvic acidemia and alaninemia due to deficiency of the pyruvate dehydrogenase[ncbi.nlm.nih.gov] Hypotonia (low muscle tone and strength), dystonia (involuntary, sustained muscle contraction), and ataxia (lack of control over movement) are often seen in people with Leigh[en.wikipedia.org]

  • Myelopathy

    Clinical hyperreflexia was tested at the MCP joint, using a six-axis load cell.[ncbi.nlm.nih.gov] Symptoms and Signs Cord compression commonly causes gradual spastic paresis, paresthesias, or both in the hands and feet and may cause hyperreflexia.[merckmanuals.com] Physical examination commonly elicits long tract signs such as spasticity, hyperreflexia, and abnormal reflexes such as Babinski or Hoffman's sign.[neurosurgery.ucla.edu]

  • Spinocerebellar Ataxia Type 13

    : Clinical features Age of onset - 43-56 years Slow progression Gait and limb ataxia Dysarthria Occular dysmetria Slow saccades Decreased vibratory sense below the knees Hyperreflexia[emedicine.com] hypotonia.[cerebellumandataxias.biomedcentral.com] Affected individuals show mild to profound mental retardation with poor or absent speech as well as gait and stance ataxia and hyperreflexia.[uniprot.org]

  • Globoid Cell Leukodystrophy

    Specialty Endocrinology Symptoms Infancy : Developmental delay, irritability, spasticity, hypotonia, microcephaly, optic atrophy Juvenile : Muscle weakness, vision loss, developmental[en.wikipedia.org] Hyperreflexia. Clonus. Pyramidal paresis of limb or limbs. Extensor plantar responses. Unsteadiness of gait. Psychomotor retardation. Dysphagia. Deafness.[patient.info]

  • Angelman Syndrome

    Cerebellar ataxia, muscle hypotonia and tremor, though constant in childhood, tend to be attenuated in adulthood.[ncbi.nlm.nih.gov] Diminished muscle tone (hypotonia) of the trunk, increased muscle tone (hypertonia) of the arms and legs, and abnormally exaggerated or brisk reflex responses (hyperreflexia[web.archive.org] HYPOTONIA ; and a peculiar facies.[hon.ch]

  • Maple Syrup Urine Disease

    […] rigidity) and hypotonia (muscle limpness) high-pitched cry Signs of intermediate and thiamine-response MSUD include: seizures neurological deficiencies developmental delays[healthline.com] Cerebral edema: If neurological signs develop or worsen (vomiting, lethargy, hyperreflexia, clonus), suspect cerebral edema.[newenglandconsortium.org] […] signs of increased intracranial pressure including the following: Papilledema Disorientation, combativeness Depressed level of consciousness Refractory vomiting Extremity hyperreflexia[ncbi.nlm.nih.gov]

  • Isolated CoQ-Cytochrome C Reductase Deficiency

    Encephalopathy can cause delayed development of mental and motor skills (psychomotor delay), movement problems, weak muscle tone (hypotonia), and difficulty with communication[ghr.nlm.nih.gov] […] cardiomyopathy and deafness; trna-lys-related cardiomyopathy-hearing loss syndrome Related symptoms: Ataxia Sensorineural hearing impairment Muscle weakness Peripheral neuropathy Hyperreflexia[mendelian.co] Peripheral neuropathy Lactic acidosis Dystonia Muscle weakness Encephalopathy Tremor Failure to thrive Acidosis Hepatomegaly Nystagmus Gait disturbance Gait ataxia Dysarthria[mendelian.co]

  • Rubinstein-Taybi Syndrome

    Defects in motor skills and coordination, sometimes accompanied with hypotonia and hyperreflexia may be seen.[symptoma.com] In addition, there may be diminished muscle tone (hypotonia), abnormally exaggerated reflexes (hyperreflexia), a stiff, unsteady gait, infrequent bowel movements (constipation[rarediseases.org] […] iliac wings 0002869 Flexion contracture 0001371 Frontal bossing 0002007 Frontal upsweep of hair Cowlick Frontal Cowlick Upswept frontal hair [ more ] 0002236 Generalized hypotonia[rarediseases.info.nih.gov]

  • Dysequilibrium Syndrome

    Clinical features include cerebellar ataxia, early-onset cataracts, mild to severe cognitive impairment, hypotonia, and muscle weakness.[ncbi.nlm.nih.gov] Clinical features include severe, progressive neurodegenerative disorder characterized by normal development until age one year, followed by onset of ataxia, muscle hypotonia[ncbi.nlm.nih.gov]

  • Autosomal Recessive Spinocerebellar Ataxia

    Neurological examination showed normal strength in all extremities, hypertonia in his legs, and hyperreflexia with Babinski signs bilaterally.[jmg.bmj.com]

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