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31 Possible Causes for Hyperreflexia, Muscle Twitch, Onset of Dysarthria in Third Decade of Life

  • Hallervorden-Spatz Syndrome

    Neurologically, opisthotonus, rigidity of extremities, dystonia, hyperreflexia, profound emaciation, and bilaterally positive Babinski signs were present.[ncbi.nlm.nih.gov] They may experience involuntary muscle contractions (dystonia) of the head and neck, resulting in repetitive movements and contortions.[ghr.nlm.nih.gov] Clinical features Dystonia Dysarthria Spasticity Choreoathetosis Parkinsonism Hyperreflexia Extensor toe signs Onset in first to third decade of life Gait change / loss of[ncbi.nlm.nih.gov]

  • Spinocerebellar Ataxia Type 5

    All had at least mild hyperreflexia, with evidence of abnormal reflex spread in the upper and/or lower limbs in four of the six subjects.[jnnp.bmj.com] Those with SCA will also often experience numbness, tingling or pain in their limbs, uncontrolled muscle tensing, muscle wasting and muscle twitching.[indycann.org] The onset of symptoms is usually in the third or fourth decade of life; however, more subtle clinical manifestations can start in early childhood.[ncbi.nlm.nih.gov]

  • Autosomal Dominant Spastic Ataxia Type 1

    Affiliated tissues include eye , and related phenotypes are supranuclear gaze palsy and hyperreflexia UniProtKB/Swiss-Prot : 75 Spastic ataxia 1, autosomal dominant: An autosomal[malacards.org] (atrophy); and muscle twitches (fasciculations).[ghr.nlm.nih.gov] […] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.medscape.com]

  • Adult-Onset Autosomal Recessive Cerebellar Ataxia

    : Clinical features Age of onset - 43-56 years Slow progression Gait and limb ataxia Dysarthria Occular dysmetria Slow saccades Decreased vibratory sense below the knees Hyperreflexia[emedicine.medscape.com] The episodes are triggered by stress, being startled or sudden movement, and often are associated with muscle twitching.[mayoclinic.org] […] and decreased ankle reflexes); movement disorders such as chorea, dystonia, and oculomotor abnormalities; pyramidal tract dysfunction such as extensor plantar responses, hyperreflexia[blogs.nejm.org]

  • Spinocerebellar Ataxia Type 12

    In a Chinese family with Spinocerebellar ataxia type 12 (SCA12), presenting with action tremor, mild cerebellar dysfunction, and hyperreflexia, genetic testing revealed abnormal[ncbi.nlm.nih.gov] Tremor, sensory loss, twitches of facial muscles, and slowness and stiffness similar to that seen in Parkinson’s disease have been observed in SCA-14.[ataxiacenter.umn.edu] […] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.medscape.com]

  • Spinocerebellar Ataxia Type 13

    : Clinical features Age of onset - 43-56 years Slow progression Gait and limb ataxia Dysarthria Occular dysmetria Slow saccades Decreased vibratory sense below the knees Hyperreflexia[emedicine.com] […] jerks or twitches (myoclonic jerks). [1] [2] [3] [4] Other symptoms may include speech difficulty ( dysarthria ), difficulty eating ( dysphagia ), slowness of movements ([rarediseases.info.nih.gov] Tremor, sensory loss, twitches of facial muscles, and slowness and stiffness similar to that seen in Parkinson’s disease have been observed in SCA-14.[ataxiacenter.umn.edu]

  • Autosomal Recessive Spinocerebellar Ataxia

    : Clinical features Age of onset - 43-56 years Slow progression Gait and limb ataxia Dysarthria Occular dysmetria Slow saccades Decreased vibratory sense below the knees Hyperreflexia[emedicine.medscape.com] […] of muscles or parts of muscles, without any rhythm or pattern, occurring in various brain disorders) 19q SCA16 39 yrs (20-66) 1-40 years Head and hand tremor 8q SCA17 ( TBP[psychology.wikia.com] Typical clinical signs and symptoms of autosomal dominant ataxias (ADCA) include the following: Limb and truncal ataxia Hyperreflexia and spasticity (pyramidal signs) are[centogene.com]

  • Spinocerebellar Ataxia Type 23

    It is characterized by gait ataxia, dysarthria , slowed saccades, ocular dysmetria, Babinski sign and hyperreflexia.[rarediseases.info.nih.gov] […] of muscles or parts of muscles, without any rhythm or pattern, occurring in various brain disorders) 19q SCA16 ( ITPR1 ) 39 yrs (20–66) 1–40 years Head and hand tremor 8q[en.wikipedia.org] […] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.medscape.com]

  • Infantile-Onset Autosomal Recessive Nonprogressive Cerebellar Ataxia

    […] coordination of movement 0001310 Gait ataxia Inability to coordinate movements when walking 0002066 Generalized hypotonia Decreased muscle tone Low muscle tone [ more ] 0001290 Hyperreflexia[rarediseases.info.nih.gov] […] of muscles or parts of muscles, without any rhythm or pattern, occurring in various brain disorders) 19q SCA16 ( ITPR1 ) 39 yrs (20–66) 1–40 years Head and hand tremor 8q[en.wikipedia.org] […] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.medscape.com]

  • Spastic Ataxia with Congenital Miosis

    Hyperreflexia suggests an upper motor neuron dysfunction. Hyperreflexia usually has a positive Babinkski's sign and spasticity .[wikidoc.org] Muscle findings of only fasiculations and the workup of such* Definition Muscle twitching is caused by minor muscle contractions in the area, or uncontrollable twitching of[flashcardmachine.com] […] in third to fifth decade of life Pure cerebellar ataxia, nystagmus, dysarthria, dysphagia, hypotonia, and generalized and/or complex partial epilepsy Spinocerebellar ataxia[emedicine.medscape.com]

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