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72 Possible Causes for Hyperreflexia, Rapid Progression to Disability

  • Primary Progressive Multiple Sclerosis

    Although progression is more rapid, age-related disability milestones are identical to relapsing-onset disease.[ncbi.nlm.nih.gov] Affected individuals may have tremors, muscle stiffness (spasticity), exaggerated reflexes (hyperreflexia), weakness or partial paralysis of the muscles of the limbs, difficulty[icdlist.com] A previous analysis of the British Columbia MS database challenged the view that disability progression is rapid in PPMS, but identified few predictors of disease progression[ncbi.nlm.nih.gov]

  • Alzheimer Disease

    Our findings may reflect the presence of greater comorbidity leading to earlier death among men than among women with AD, 57 or a more rapid progression of AD in women. 58[dx.doi.org] - 61 The inherent survival advantage of women in general may lead women to live longer, tolerating greater disability, than men.[dx.doi.org]

  • Primary Lateral Sclerosis

    Patients with more severe physical disability and a more rapid rate of disease progression had increased sensorimotor connectivity values.[ncbi.nlm.nih.gov] […] disease; a slowly progressive degenerative disorder of the motor neurons of the cerebral cortex, resulting in widespread weakness on an upper motor neuron basis; spasticity, hyperreflexia[medical-dictionary.thefreedictionary.com] […] idiopathic non-familial motor neuron disease characterized by slowly progressive upper motor neuron dysfunction leading to spasticity, mild weakness in voluntary muscle movement, hyperreflexia[orpha.net]

  • Myelitis

    […] one third remain severely disabled Poor prognostic indicators rapid progression of symptoms back pain spinal shock absent central conduction on somatosensory evoked potential[lifeinthefastlane.com] The patient with detrusor hyperreflexia had an unrecordable CMCT-TA.[jnnp.bmj.com] Progression ; Transverse myelitis (TM) The progression is rapid • time to maximal disability is more than 4 hr and fewer than 21 days. A.[slideshare.net]

  • Subacute Transverse Myelitis

    Progression ; Transverse myelitis (TM) The progression is rapid • time to maximal disability is more than 4 hr and fewer than 21 days. A.[slideshare.net] An areflexic cystometrogram tended to change to a low compliance bladder, followed by detrusor hyperreflexia or a normal cystometrogram.[nature.com] Neurological Examination: spastic paraplegia, Babinski sign bilateral patellar, hyperreflexia and aquiliana, sensorial level T4.[omicsonline.org]

  • Cervical Myelopathy

    . 5% rapid onset with lengthy disability.[slideshare.net] BACKGROUND: Gait dysfunction associated with spasticity and hyperreflexia is a primary symptom in patients with compression of cervical spinal cord.[ncbi.nlm.nih.gov] Abstract Diabetes may affect the typical physical findings associated with cervical spondylotic myelopathy, as coexisting diabetic neuropathy may dampen expected hyperreflexia[ncbi.nlm.nih.gov]

  • Autosomal Dominant Spastic Paraplegia Type 12

    RESULTS: The patients in this family showed an early onset and rapid progression of symptoms, resulting in severe disability, with a large proportion of affected members requiring[ncbi.nlm.nih.gov] OMIM : 58 Spastic paraplegia-12 is an autosomal dominant neurodegenerative disorder characterized by lower limb spasticity and hyperreflexia, resulting in walking difficulties[malacards.org] Results: The patients in this family showed an early onset and rapid progression of symptoms, resulting in severe disability, with a large proportion of affected members requiring[n.neurology.org]

  • Amyotrophic Lateral Sclerosis

    One woman with ALS received intracranial injection of adult olfactory ensheathing glia (OEG) transplantation and her disease progressed at a more rapid rate after the procedure[doi.org] If upper motor neurons are also damaged, spasticity and hyperreflexia and pathologic reflexes, such as Babinski’s sign, can also be observed.[flexikon.doccheck.com] […] remains normal Physical exam neck ptosis (neck drop) due to neck extensor weakness manual muscle testing elicits muscle cramping upper motor neuron (UMN) signs spasticity hyperreflexia[orthobullets.com]

  • Hallervorden-Spatz Syndrome

    Rapid progression of the disease may lead to severe disability, life-threatening state, the status dystonicus, and several critical events such as hyperpyrexia, dehydration[file.scirp.org] Neurologically, opisthotonus, rigidity of extremities, dystonia, hyperreflexia, profound emaciation, and bilaterally positive Babinski signs were present.[ncbi.nlm.nih.gov] Each patient had spastic gait, dysarthria, dystonic posturing of both arms and generalized hyperreflexia, but no Kayser-Fleischer rings or retinitis pigmentosa.[ncbi.nlm.nih.gov]

  • Cervical Spinal Cord Tumor

    Surgery is indicated if the diagnosis is in doubt, a tissue diagnosis is required, the spine is unstable or neurologic deterioration is severe, rapid and progressive.[aafp.org] A neurological examination revealed hypesthesia and mild weakness in her left C8 spinal nerve distribution, as well as mild hyperreflexia and a Babinski’s sign in the left[jmedicalcasereports.biomedcentral.com] Below that level, Upper Motor Neuron (UMN) findings are those of spasticity, hyperreflexia with upgoing Plantar reflex also called Babinski’s sign With Extradural lesion ([clinicaladvisor.com]

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