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92 Possible Causes for Hyperreninemia, Hypotension, Muscle Weakness

  • Gitelman Syndrome

    The clinical spectrum is wide and usually characterized by chronic fatigue, cramps, muscle weakness and paresthesiae.[ncbi.nlm.nih.gov] The main features of this syndrome include normal or low blood pressure, hypokalemia, metabolic alkalosis, hypomagnesemia, hypocalciuria, and hyperreninemia.[ncbi.nlm.nih.gov] This paper presents 3 sisters with Gitelman syndrome who could not tolerate magnesium supplements, and whose hypotension and polyuria were eliminated by taking 2 mg/kg/day[ncbi.nlm.nih.gov]

  • Hyponatremia

    A 52-year-old Sri Lankan man presented with anorexia, nausea, fatigue, generalized muscle weakness, and cramps for 1 week.[ncbi.nlm.nih.gov] In this setting, release of both antidiuretic hormone (ADH) (increases renal permeability to water) and renin (increases renal sodium retention) occurs.[doi.org] After several weeks of suffering from gastroenteritis with vomiting, she presented with disturbance of consciousness, hypotension, dehydration, and severe hyponatremia (108[ncbi.nlm.nih.gov]

  • Addison's Disease

    The physical examination was completely normal except for muscle weakness, hyperpigmentation on labial mucosa and skin in a patient.[ncbi.nlm.nih.gov] […] concentration after 60 minutes to a peak of 18 mcg/dL Plasma renin : Mineralocorticoid deficiency is confirmed with a relatively low aldosterone level in the setting of hyperreninemia[pedclerk.bsd.uchicago.edu] […] of hypotension in these individuals.[ncbi.nlm.nih.gov]

  • Renal Salt-Wasting Syndrome

    […] wasting [ wāst ing ] 1. the gradual deterioration of an individual, usually with loss of strength and muscle mass; it may be accompanied by loss of appetite, which makes it[medical-dictionary.thefreedictionary.com] The proximal site of salt transport defect has been suggested by the absence of hyperreninemia and hypokalemia, which would be a distinguishing feature of Bartter’s syndrome[karger.com] Seven of seventy patients treated with cisplatin over 18 months developed salt-wasting nephropathy and orthostatic hypotension.[annals.org]

  • Hypokalemia

    Neurological examination showed a lower extremity muscle weakness with three-fifths muscular strength of the quadriceps and tibialis anterior muscle on both sides.[ncbi.nlm.nih.gov] Intravenous fluid boluses of normal saline (10.5 L in about 24 h) and vasopressors were started with rapid correction of hypotension.[ncbi.nlm.nih.gov] Clinical features include transient periods of muscle weakness and tetany, dizziness, abdominal pains and constipation.[ncbi.nlm.nih.gov]

  • Bartter's Disease

    Clinical findings Proximal muscle weakness, failure to thrive, short stature, convulsions, tetany, cramps, ileus, gout, mental retardation, enuresis, nocturia, polyuria, salt[medical-dictionary.thefreedictionary.com] Bartter syndrome is characterized by hyperplasia of the juxtaglomerular cells along with: hypokalemia metabolic alkalosis hypotension or normotension elevated plasma renin[radiopaedia.org] History Part I: Pattern Recognition: Bartter and Gitelman syndromes Unexplained hypokalemia, metabolic alkalosis Normotension or mild hypotension Bartter syndrome Polyuria[clinicaladvisor.com]

  • Bartter Syndrome

    Clinical findings Proximal muscle weakness, failure to thrive, short stature, convulsions, tetany, cramps, ileus, gout, mental retardation, enuresis, nocturia, polyuria, salt[medical-dictionary.thefreedictionary.com] Bartter syndrome is characterized by hyperplasia of the juxtaglomerular cells along with: hypokalemia metabolic alkalosis hypotension/normotension elevated plasma renin elevate[radiopaedia.org] Schwartz-Bartter syndrome consists of: increased urinary osmolality, elevated urinary sodium, low serum osmolality, in a euvolemic patient, without edema, who is not hypotensive[medichub.ro]

  • Hypoaldosteronism

    A 53-year-old man with retinitis pigmentosa, who had two years' complaints of general malaise and muscle weakness, noticed occasional attacks of the cramps of the lower legs[ncbi.nlm.nih.gov] These results suggest adrenal insensitivity to angiotensin II, possibly a defect in adrenal angiotensin II receptors, as the cause of hypoldosteronism with hyperreninemia[ncbi.nlm.nih.gov] It can also cause urinary sodium wasting, leading to volume depletion and hypotension.[en.wikipedia.org]

  • 18-Hydroxylase Deficiency

    weakness.[ghr.nlm.nih.gov] Decreased circulating aldosterone level ; Dehydration ; Episodic fever ; Failure to thrive ; Feeding difficulties in infancy ; Growth delay ; Hyperkalemia ; Hyponatremia ; Hypotension[mousephenotype.org] […] failure Growth retardation Poor growth Retarded growth [ more ] 0001510 Hyperkalemia Elevated serum potassium levels 0002153 Hyponatremia Low blood sodium levels 0002902 Hypotension[rarediseases.info.nih.gov]

  • Metabolic Alkalosis

    In most patients, the symptom of muscle weakness and polyuria occur early in life, which may be attributed to potassium depletion.[ncbi.nlm.nih.gov] We describe a case of medication induced metabolic alkalosis in a maintenance dialysis patient who developed severe hypotension while undergoing a lactate hemofiltration procedure[ncbi.nlm.nih.gov] weakness; myalgia; muscle cramps; tremors in the hands; and twitching muscles.[battlediabetes.com]

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