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39 Possible Causes for Hyperreninemia, Plasma Renin Activity Decreased

  • Essential Hypertension

    Hyperreninemia promotes conversion of Ang I to Ang II, causing severe vasoconstriction and aldosterone release.[] High renin levels predispose to hypertension by causing sodium retention through the following mechanism: Increased renin Increased angiotensin II Increased vasoconstriction[]

  • Conn Syndrome

    plasma renin activity; may be associated with small, benign adrenocortical adenomas.[] When renin increases (due to low blood pressure, decreased blood flow to the kidneys or to a sodium deficiency), aldosterone increases; when renin decreases, aldosterone decreases.In[] Condition similar to Conn's syndrome may be caused by kidneys that can produce an excessive amount of renin.[]

  • Gitelman Syndrome

    Prostaglandin excretion is normal and plasma renin activity and plasma aldosterone concentration are only slightly elevated compared to Bartter syndrome.[] The main features of this syndrome include normal or low blood pressure, hypokalemia, metabolic alkalosis, hypomagnesemia, hypocalciuria, and hyperreninemia.[] Both probands show hypokalemia, hypochloraemia, hypocalcinuria, hyperreninemia, and hyperaldosteronemia; Proband A has normal serum magnesium and increased urinary sodium[]

  • Hypoaldosteronism

    Plasma renin activity (PRA) (ng/ml/h): resting 0.34 /- 0.3; standing 0.6 /- 0.4, post-frusemide 0.9 /- 0.5, decreased significantly with respect to the other three groups.[] These results suggest adrenal insensitivity to angiotensin II, possibly a defect in adrenal angiotensin II receptors, as the cause of hypoldosteronism with hyperreninemia[] Case Report Abstract Author Information We report a child with primary renal tubular alkalosis who had hypokalemia, profound hyperreninemia, and hypoaldosteronism.[]

  • 18-Hydroxylase Deficiency

    Because minimal aldosterone is secreted, salt is lost, leading to hyponatremia, hyperkalemia, and increased plasma renin activity.[] […] simple virilizing form, cortisol synthesis is impaired, leading to increased androgen activity, but there is sufficient enzyme activity to maintain normal, or only slightly decreased[]

  • Renovascular Hypertension

    The captopril test showed an increase in serum aldosterone level, with a concomitant increase in plasma renin activity and decrease in blood pressure.[] Over days to weeks, blood pressure remains elevated, but the course and presence of hyperreninemia vary with the presence and function of the contralateral kidney.[] […] in luminal cross-sectional area. 33 , 34 Lateralization of plasma renin activity to the stenotic kidney suggests a haemodynamically significant stenosis.[]

  • Hyponatremia

    Importantly, decreases in plasma renin activity, inflammatory markers, and even natriuretic peptide levels have been demonstrated with hypertonic saline administration in[] In this setting, release of both antidiuretic hormone (ADH) (increases renal permeability to water) and renin (increases renal sodium retention) occurs.[] In addition, it has been found that there is an increase in plasma renin activity and c-Fos expression in the SFO of rats submitted to a water deprivation-induced sodium appetite[]

  • Cystic Kidney

    Indomethacin therapy decreased plasma renin activity (PRA), plasma aldosterone, and urinary loss of potassium and sodium, while serum potassium approached normal levels.[] Abstract Adult onset Fanconi syndrome with medullary cystic kidney was diagnosed in a 30-year-old male with muscular weakness, hypokalemia, normal BP, hyperreninemia, and[]

  • Renal Hypertension

    […] levels of active and acid-activatable inactive renin significantly increased and angiotensin II decreased, whereas no consistent changes in urinary kallikrein excretion occurred[] Abstract In the present article, we report, for the first time, a prenatal diagnosis of a congenital mesoblastic nephroma in combination with a post-partum hyperreninemia[] Over days to weeks, blood pressure remains elevated, but the course and presence of hyperreninemia vary with the presence and function of the contralateral kidney.[]

  • Cerebral Salt-Wasting Syndrome

    Aldosterone levels were normal [ 12 ] or decreased [ 20 – 22 ], cortisol and ACTH were within a normal range [ 19 – 21, 24 ], and plasma renin activity was decreased [ 20[] The proximal site of salt transport defect has been suggested by the absence of hyperreninemia and hypokalemia, which would be a distinguishing feature of Bartter's syndrome[] Activation of the renin-angiotensin-aldosterone system leads to sodium retention with a low ( Decreased effective plasma volume (decreased oncotic pressure) (volume contraction[]

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