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36 Possible Causes for Hypertonicity of the Lower Limbs, Neonatal Hypotonia

  • Neonatal Sepsis

    Patients and methods Patients This study was carried out in the neonatal ICU in Benha Children Hospital over 60 neonates presenting with late-onset neonatal septicemia.[mmj.eg.net] Hypertonia was the most frequent dysfunction (17 evaluated as hypertonic and seven as hypotonic), mainly affecting the upper and/or lower limbs, or one hemisphere.[scielo.br] Neonatal sepsis or septicaemia is a clinical syndrome characterized by systemic signs of circulatory compromise (e.g., poor peripheral perfusion, pallor, hypotonia, poor responsiveness[journals.plos.org]

  • Autosomal Recessive Lower Motor Neuron Disease with Childhood Onset

    SMA1 must be distinguished from other causes of neonatal hypotonia which include CNS malformations, metabolic diseases, infections, and congenital myopathies.[neuropathology-web.org] limbs, hypertonic urinary bladder, and impaired vibration sense.[clinicalgate.com] Selected Upper Motor Neuron Disorders Hereditary Spastic Paraplegia Like PLS, HSP is a disorder of UMNs and presents most commonly with progressive spasticity, weakness of the lower[clinicalgate.com]

  • Autosomal Recessive Spastic Paraplegia Type 18

    SPG52 AP4S1 14q12 AP4S1 Complicated: neonatal hypotonia that progresses to hypertonia. Dysmorphic features.[scielo.br] The lower limb spasticity is the prominent finding on examination, particularly in the hamstrings, quadriceps, and ankles.[jnnp.bmj.com] In severe cases, the neonatal hypotonia may resemble spinal muscular atrophy but over 90% of cases develop spasticity, although possibly not until the second year of life.[patient.info]

  • Cerebral Palsy

    […] seizures, hypertonia, hypotonia, or reflex suppression) should be followed closely.[merckmanuals.com] All had spasticity affecting predominantly the lower limbs, although 2 also had mild hypertonia and ataxia of the upper limbs.[ncbi.nlm.nih.gov] […] or abnormal neonatal reflexes).[doi.org]

  • Spastic Paraplegia

    SPG52 AP4S1 14q12 AP4S1 Complicated: neonatal hypotonia that progresses to hypertonia. Dysmorphic features.[scielo.br] The lower limb spasticity is the prominent finding on examination, particularly in the hamstrings, quadriceps, and ankles.[jnnp.bmj.com] SPG47 AP4B1 1p13.2 AP-4 complex subunit beta-1 Complicated: neonatal hypotonia, progressive hypertonia, severe mental retardation, ataxia, seizures, TCC.[scielo.br]

  • Autosomal Dominant Spastic Paraplegia Type 10

    SPG52 AP4S1 14q12 AP4S1 Complicated: neonatal hypotonia that progresses to hypertonia. Dysmorphic features.[scielo.br] limb spasticity, pyramidal weakness, hyperreflexia and hypertonic bladder involvement.[medicbind.com] The lower limb spasticity is the prominent finding on examination, particularly in the hamstrings, quadriceps, and ankles.[jnnp.bmj.com]

  • Autosomal Recessive Spastic Paraplegia Type 20

    SPG52 AP4S1 14q12 AP4S1 Complicated: neonatal hypotonia that progresses to hypertonia. Dysmorphic features.[scielo.br] limb spasticity, pyramidal weakness, hyperreflexia and hypertonic bladder involvement.[medicbind.com] The lower limb spasticity is the prominent finding on examination, particularly in the hamstrings, quadriceps, and ankles.[jnnp.bmj.com]

  • Autosomal Recessive Spastic Paraplegia Type 28

    SPG52 AP4S1 14q12 AP4S1 Complicated: neonatal hypotonia that progresses to hypertonia. Dysmorphic features.[scielo.br] The lower limb spasticity is the prominent finding on examination, particularly in the hamstrings, quadriceps, and ankles.[jnnp.bmj.com] […] form is fatal; the early childhood form causes hypotonia and psychomotor retardation; the late childhood form causes poor coordination, gait and language acquisition disorders[elsevier.es]

  • X-Linked Spastic Paraplegia Type 2

    In severe cases, the neonatal hypotonia may resemble spinal muscular atrophy but over 90% of cases develop spasticity, although possibly not until the second year of life.[patient.info] limb hypertone.[slideheaven.com] The lower limb spasticity is the prominent finding on examination, particularly in the hamstrings, quadriceps, and ankles.[jnnp.bmj.com]

  • Warburg Micro Syndrome 3

    […] and infantile muscular hypotonia (90 %); - swallowing disorders, gastro-esophageal reflux - cardiac abnormalities (50 %): ASD, VSD, valvular malformations - moderate facial[sites.uclouvain.be] , hypertonic lower limbs with contractures, myoclonic seizures, and hypoplastic labia minora and clitoral hypoplasia.[bio2rdf.org] Upper limbs are hypotonic and lower limbs hypertonic. Deep tendon reflexes are brisk. Pupil is atonic [Figure 2] .[pediatricneurosciences.com]

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