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43 Possible Causes for Hypertonicity of the Lower Limbs, Rapid Progression, Sensation Normal

  • Autosomal Recessive Lower Motor Neuron Disease with Childhood Onset

    Disease progression was rapid, and the majority of patients died from respiratory failure within 1–5 years after onset of disease.[link.springer.com] DSMA4 is characterized by childhood onset, generalized muscle weakness and atrophy with denervation and normal sensation. Bulbar symptoms and pyramidal signs are absent.[uniprot.org] limbs, hypertonic urinary bladder, and impaired vibration sense.[clinicalgate.com]

  • X-linked Parkinsonism-Spasticity Syndrome

    .  patients with MSA-P have a more rapid functional deterioration than those with MSA-C 33.  MSA-P-associated parkinsonism :  progressive akinesia and rigidity  jerky[slideshare.net] There was a mild impairment of vibration sense, but proprioception and superficial sensation were normal.[journals.plos.org] The lower limb spasticity is the prominent finding on examination, particularly in the hamstrings, quadriceps, and ankles.[jnnp.bmj.com]

  • Paraparesis

    Rapid progress is being made in the molecular genetics of HSP, which will affect the way we investigate and diagnose HSP in the future, and this is discussed later.[jnnp.bmj.com] Sensory examination showed loss of vibration in lower limbs with normal sensation to pinprick, fine touch and propioception.[n.neurology.org] On the other hand, her upper limbs had normal tone, intact sensation, and a power rating of 5/5. Reflexes were normal in upper and lower limbs.[dovepress.com]

  • Arachnoiditis

    Two months later, she developed rapid, progressive paraplegia and sphincter dysfunction.[ncbi.nlm.nih.gov] : Mental status; Hearing; Sensation; Bladder, Bowel & Sexual functions Laboratory Somatosensory evoked potentials: Prolonged cortical responses & central sensory delay Return[neuromuscular.wustl.edu] Methods Examination revealed generalized weakness and hypertonicity of both lower limbs with loss of all sensory modalities below D7.[doi.org]

  • Autosomal Recessive Spastic Paraplegia Type 35

    It has a rapid progression and many patients become wheelchair-bound as young adults. Patients manifest cognitive decline associated with leukodystrophy.[uniprot.org] There was a mild impairment of vibration sense, but proprioception and superficial sensation were normal.[journals.plos.org] The lower limb spasticity is the prominent finding on examination, particularly in the hamstrings, quadriceps, and ankles.[jnnp.bmj.com]

  • Lower Motor Neuron Syndrome with Late-Adult Onset

    Disease progression was rapid, and the majority of patients died from respiratory failure within 1–5 years after onset of disease.[link.springer.com] sensation -normal nerve conduction velocities -denervation on EMG -dec. # of motor units -muscle biopsy shows atrophic fibers & fiber grouping -seen in MRI -present: lower[brainscape.com] limbs, hypertonic urinary bladder, and impaired vibration sense.[clinicalgate.com]

  • Spastic Paraplegia

    Rapid progress is being made in the molecular genetics of HSP, which will affect the way we investigate and diagnose HSP in the future, and this is discussed later.[jnnp.bmj.com] There was a mild impairment of vibration sense, but proprioception and superficial sensation were normal.[journals.plos.org] Peripheral nerves are normal in patients with pure HSP. 38. Vibratory sensation is often mildly diminished in the distal lower extremities. 39.[slideshare.net]

  • Congenital Anomaly of the Spine

    Rate of progression from greatest to least is: unilateral unsegmented bar with contralateral hemivertebra greatest potential for rapid progression (5 to10 degrees/year) unilateral[orthobullets.com] He had full range of motion of his cervical spine with no pain, normal upper and lower extremity strength and sensation, and normal reflexes throughout.[aafp.org] Severe motor impairment was present in nine patients, five of whom were paraparetic and four paraplegic; one newborn (case 7) presented with moderately hypertonic lower limbs[ajnr.org]

  • Hereditary Spastic Paraplegia

    A homozygous mutation c.160_169dup in the FA2H gene, which resulted in SPG35 phenotype, may present with rapid progressive spastic paraplegia at an early age.[ncbi.nlm.nih.gov] Sensation was normal. Ophthalmological examination was normal.[scielo.br] […] and weakness - limited mainly to the lower extremities.[whonamedit.com]

  • Cerebral Palsy

    Rapid progression of scoliosis following insertion of intrathecal baclofen pump.[doi.org] […] earlier than 18 months of age) For the mother Any adverse effects severe enough to stop treatment Postpartum haemorrhage (however reported by the trialists) Mode of birth (normal[doi.org] All had spasticity affecting predominantly the lower limbs, although 2 also had mild hypertonia and ataxia of the upper limbs.[ncbi.nlm.nih.gov]

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