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2,405 Possible Causes for Hypertonicity of the Lower Limbs, Sensation Normal, Subclinical Axonal Neuropathy

  • Autosomal Recessive Spastic Paraplegia Type 56

    Weakness: Some patients Distal Hands & Feet Fasciculations Sensation: Normal or Reduced (Panmodal; Posterior column) Bladder: Often normal Progression Over few years or Slow[neuromuscular.wustl.edu] The lower limb spasticity is the prominent finding on examination, particularly in the hamstrings, quadriceps, and ankles.[jnnp.bmj.com] Some SPG56 patients may have a subclinical axonal neuropathy.[malacards.org]

  • Autosomal Recessive Lower Motor Neuron Disease with Childhood Onset

    DSMA4 is characterized by childhood onset, generalized muscle weakness and atrophy with denervation and normal sensation. Bulbar symptoms and pyramidal signs are absent.[uniprot.org] limbs, hypertonic urinary bladder, and impaired vibration sense.[clinicalgate.com] Clinically, AMAN is part of the GBS spectrum but distinguished by normal sensation and nerve conduction studies characterised by low distal motor evoked amplitudes, normal[jnnp.bmj.com]

    Missing: Subclinical Axonal Neuropathy
  • Autosomal Recessive Spastic Paraplegia Type 46

    There was a mild impairment of vibration sense, but proprioception and superficial sensation were normal.[journals.plos.org] The lower limb spasticity is the prominent finding on examination, particularly in the hamstrings, quadriceps, and ankles.[jnnp.bmj.com] Some SPG56 patients may have a subclinical axonal neuropathy. {ECO:0000269 PubMed:23176821}.[genecards.org]

  • Autosomal Dominant Spastic Paraplegia Type 17

    There was no voluntary movement of either leg, spontaneous clonus was present, planter responses were extensor bilaterally, and sensation was normal.[jnnp.bmj.com] The lower limb spasticity is the prominent finding on examination, particularly in the hamstrings, quadriceps, and ankles.[jnnp.bmj.com] Some SPG56 patients may have a subclinical axonal neuropathy.[malacards.org]

  • Autosomal Dominant Spastic Paraplegia Type 41

    There was a mild impairment of vibration sense, but proprioception and superficial sensation were normal.[journals.plos.org] The lower limb spasticity is the prominent finding on examination, particularly in the hamstrings, quadriceps, and ankles.[jnnp.bmj.com] Some SPG56 patients may have a subclinical axonal neuropathy.[malacards.org]

  • Autosomal Dominant Spastic Paraplegia Type 29

    There was a mild impairment of vibration sense, but proprioception and superficial sensation were normal.[journals.plos.org] The lower limb spasticity is the prominent finding on examination, particularly in the hamstrings, quadriceps, and ankles.[jnnp.bmj.com] Some SPG56 patients may have a subclinical axonal neuropathy.[malacards.org]

  • Carpal Tunnel Syndrome

    In the early stages the symptoms of tingling intermittent and sensation will return to normal.[bssh.ac.uk] The Y169H missense variant segregates with an axonal neuropathy, whereas the nonsense R954X mutation is associated with subclinical evidence of the carpal tunnel syndrome;[doi.org] People with carpal tunnel syndrome often describe awakening with a tingling sensation and the need to shake out the hands to recover normal feeling.[drugs.com]

    Missing: Hypertonicity of the Lower Limbs
  • X-linked Parkinsonism-Spasticity Syndrome

    There was a mild impairment of vibration sense, but proprioception and superficial sensation were normal.[journals.plos.org] The lower limb spasticity is the prominent finding on examination, particularly in the hamstrings, quadriceps, and ankles.[jnnp.bmj.com] Sensation and strength are usually normal. Reflexes are normal but may be difficult to elicit because of marked tremor or rigidity.[merckmanuals.com]

    Missing: Subclinical Axonal Neuropathy
  • Paraparesis

    Sensory examination showed loss of vibration in lower limbs with normal sensation to pinprick, fine touch and propioception.[n.neurology.org] The lower limb spasticity is the prominent finding on examination, particularly in the hamstrings, quadriceps, and ankles.[jnnp.bmj.com] On the other hand, her upper limbs had normal tone, intact sensation, and a power rating of 5/5. Reflexes were normal in upper and lower limbs.[dovepress.com]

    Missing: Subclinical Axonal Neuropathy
  • Arachnoiditis

    : Mental status; Hearing; Sensation; Bladder, Bowel & Sexual functions Laboratory Somatosensory evoked potentials: Prolonged cortical responses & central sensory delay Return[neuromuscular.wustl.edu] Methods Examination revealed generalized weakness and hypertonicity of both lower limbs with loss of all sensory modalities below D7.[doi.org] Occasional patients with 2nd exacerbation Contractures Other transient features: May persist in severe cases Eye: Blurred vision; Nystagmus Speech difficulties: Spasticity Normal[neuromuscular.wustl.edu]

    Missing: Subclinical Axonal Neuropathy