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372 Possible Causes for Hypertrichosis of Eyebrows, Leukoerythroblastic Anemia, Mutation in the MLL Gene

  • Wiedemann-Steiner Syndrome

    Utilizing a whole-exome sequencing approach, the group identified de novo mutations in the mixed lineage leukemia ( MLL ) gene in five of six individuals with the syndrome[news-medical.net] […] cubiti, facial dysmorphism (hypertelorism, long eyelashes, thick eyebrows, downslanted, vertically narrow, long palpebral fissures, wide nasal bridge, broad nasal tip, long[orpha.net] Facial characteristics include long eyelashes, thick or arched eyebrows with a lateral flare, and downslanting and vertically narrow palpebral fissures.[uniprot.org]

    Missing: Leukoerythroblastic Anemia
  • Small-Cell Carcinoma of the Lung

    […] amplification seen in FGFR1, MYCL, E2F2, and CCN2 genes Gene mutation seen in CREBBP, EP300, MLL, PTEN, SLIT2, and EPHA7 genes And gene inactivation seen in TP53 and RB1[dovemed.com] […] genes (in many cases) No preinvasive lesions, such as diffuse idiopathic pulmonary neuroendocrine hyperplasia (DIPNECH), or genetic mutations on MEN1 gene, which are both[dovemed.com] […] in individuals who have been continuously smoking for several decades (up to 30 years or more) Many genetic and chromosomal anomalies have been reported, which include: Gene[dovemed.com]

    Missing: Hypertrichosis of Eyebrows
  • Acute Myelocytic Leukemia

    They include internal tandem duplication of the FLT3 gene, partial tandem duplication of the MLL gene, mutations of the CEBPA and NPM1 genes and aberrant expression of the[ncbi.nlm.nih.gov] Blood film shows teardrop RBCs and a leukoerythroblastic film. Bone marrow biopsy shows reticulin fibrosis.[online.epocrates.com] These genes include FLT3, IDH1, IDH2, and MLL. Targeted therapies often have fewer side effects than conventional chemotherapy drugs.[mskcc.org]

    Missing: Hypertrichosis of Eyebrows
  • Renal Cell Carcinoma

    Manual pathway analysis identified candidate driver mutations in known cancer-associated genes, such as PTEN , NRAS , KRAS , TP53 , TSC2 , and those in the MLL and ARID families[nejm.org]

    Missing: Hypertrichosis of Eyebrows
  • Hodgkin Lymphoma

    gene.[ncbi.nlm.nih.gov] […] agents show deletion 5q/monosomy 5 and deletion 7q/monosomy 7; in contrast, those who were treated with topoisomerase II inhibitors show 11q23 translocations involving the MLL[ncbi.nlm.nih.gov] At the molecular level, there are two types of mutations: Class I, which alter the RAS-BRAF signal transduction pathways and increase cell proliferation; Class II, which disrupt[ncbi.nlm.nih.gov]

    Missing: Hypertrichosis of Eyebrows
  • Blast Phase

    Interestingly, JAK2V617F mutation became negative. Meanwhile, MLL-PTD fusion gene and TET2 mutation were detected (Table 1).[journals.lww.com] , is converted to MLL-PTD fusion gene through a gain-of-function intragenic self-fusion mutation. [8] MLL-PTD that had not been detected in MPN, [9] was reported in about[journals.lww.com] Whereas, prognosis for TET2 mutation in post-MPN AML was controversial. [7] The MLL gene, that encodes a transcription factor of histone H3 lysine 4 methyltransferase activity[journals.lww.com]

    Missing: Hypertrichosis of Eyebrows
  • Acute Myelomonocytic Leukemia

    Poor-risk factors include deletion of 5q and 7q, trisomy 8, t(6; 9), t(9; 22), most translocations involving chromosome 11q23, and mutations of the MLL gene, a history of[northshore.org] The presence of MLL gene is usually an unfavorable prognostic marker.[emedicine.medscape.com] The presence of a mutated DNA methyl transferase gene DNMT3A has been associated with a worsened prognosis in CN-AML and adverse-risk AML. 37 Partial tandem duplications of[nature.com]

    Missing: Hypertrichosis of Eyebrows
  • Adenocarcinoma of the Breast

    Adenocarcinoma of the breast is a term encompassing several types of tumors such as ductal and lobular carcinomas. An asymptomatic painless mass is usually the only symptom in the early stages, whereas an array of constitutional and localized symptoms may be seen in more advanced disease. Mammography and other[…][symptoma.com]

    Missing: Hypertrichosis of Eyebrows Mutation in the MLL Gene
  • Adenocarcinoma of the Prostate

    Abstract High Gleason score 8 to 10 adenocarcinoma is the most aggressive and potentially lethal form of prostate cancer. The 2005 International Society of Urological Pathology (ISUP)-modified Gleason grading scheme defines several gland arrangements of high Gleason grade patterns 4 and 5. The aim of this[…][ncbi.nlm.nih.gov]

    Missing: Hypertrichosis of Eyebrows Mutation in the MLL Gene
  • Skin Cancer

    The present review is aimed at providing an overview of skin cancer with particular focus on occupational concern and giving evidence-based recommendation for effective prevention at workplace. We performed a systematic search of literature using PubMed and the Cochrane Library. Outcome of preventive strategies[…][ncbi.nlm.nih.gov]

    Missing: Hypertrichosis of Eyebrows Mutation in the MLL Gene