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8,398 Possible Causes for Hypertrichosis of Eyebrows, Mutation in the MLL Gene, Weight Loss

  • Wiedemann-Steiner Syndrome

    Utilizing a whole-exome sequencing approach, the group identified de novo mutations in the mixed lineage leukemia ( MLL ) gene in five of six individuals with the syndrome[news-medical.net] […] cubiti, facial dysmorphism (hypertelorism, long eyelashes, thick eyebrows, downslanted, vertically narrow, long palpebral fissures, wide nasal bridge, broad nasal tip, long[orpha.net] Facial characteristics include long eyelashes, thick or arched eyebrows with a lateral flare, and downslanting and vertically narrow palpebral fissures.[uniprot.org]

    Missing: Weight Loss
  • Fucosidosis

    Signs can include loss of learned behavior, change in temperament, blindness, loss of balance, deafness and weight loss.[vetgen.com] […] temperament Blindness Loss of balance Deafness Weight loss From the onset, disease progress is quick and fatal.Just like the human version, canine fucosidosis is a recessive[en.wikipedia.org] As the disease progresses, the loss of weight and muscle mass sustained may constitute life-threatening sequelae that can lead to a patient's demise even within the first[symptoma.com]

    Missing: Mutation in the MLL Gene
  • Small-Cell Carcinoma of the Lung

    The clinical presentation encompasses cough, hemoptysis, chest pain, and systemic signs of weight loss and fatigue in patients who reached the later stages of the disease.[symptoma.com] […] amplification seen in FGFR1, MYCL, E2F2, and CCN2 genes Gene mutation seen in CREBBP, EP300, MLL, PTEN, SLIT2, and EPHA7 genes And gene inactivation seen in TP53 and RB1[dovemed.com] A 67-year-old female presenting with a history of weight loss and abdominal distension was noted on examination to have ascites.[ncbi.nlm.nih.gov]

    Missing: Hypertrichosis of Eyebrows
  • Renal Cell Carcinoma

    I thought the weight loss was stress from the move. I was shocked when they said it was kidney cancer.[votrient.com] Manual pathway analysis identified candidate driver mutations in known cancer-associated genes, such as PTEN , NRAS , KRAS , TP53 , TSC2 , and those in the MLL and ARID families[nejm.org] Most paraneoplastic signs and symptoms correlated with poor survival, although on multivariate analysis hypoalbuminemia, weight loss, anorexia and malaise predicted shorter[ncbi.nlm.nih.gov]

    Missing: Hypertrichosis of Eyebrows
  • Lymphoma

    Weight loss Weight loss usually occurs rapidly for no known reason. Often an individual can lose ten to fifteen pounds over a couple of months.[web.archive.org] Many of these gene mutations figure importantly in the revised WHO classification.[doi.org] Unexplained Weight Loss Weight loss in the context of lymphoma usually occurs rapidly and it may have various causes.[lymphoma.about.com]

    Missing: Hypertrichosis of Eyebrows
  • Leukemia

    The common symptoms of the disease include the following: Undue weight loss Constant felling of tiredness and fatigue Pain in bone Fever accompanied by chills Excessive sweating[symptoma.com] For example, PML-RARA, MYH11-CBFB, and MLL -containing fusion genes were mutually exclusive of mutations in NPM1 and DNMT3A (P RUNX1 and TP53 mutations were mutually exclusive[nejm.org] loss (including ‘anorexia’, ‘weight loss’ and ‘anorexia/weight loss’), weakness/fatigue (including ‘weakness’, ‘fatigue’, ‘weakness/fatigue’), malaise/fatigue (including[doi.org]

    Missing: Hypertrichosis of Eyebrows
  • Acute Lymphoblastic Leukemia Type L1

    Both leukemia itself and the treatment can lead to many problems such as bleeding, weight loss, and infections.[medlineplus.gov] Children who develop ALL in the first year of life have a very poor prognosis, especially if their leukemia cells contain a mutated gene called MLL.[texasoncology.com] We have recently shown that FLT3 is highly expressed and often mutated in ALLs with rearrangement of the mixed lineage leukemia ( MLL ) gene on chromosome 11q23.[bloodjournal.org]

    Missing: Hypertrichosis of Eyebrows
  • B-Cell Lymphoma

    Some people may also develop patches of inflamed skin across their body or experience fevers, night sweats and unexplained weight loss.[leukaemia.org.au] […] found mutated are DIS3 , a gene involved in mRNA processing, and a number of genes with epigenetic activities such as MLL, MLL2, MLL3 and UTX . 15 Therapeutic targeting of[haematologica.org] Frequently, BCL is associated with fever, night sweats, and weight loss.[symptoma.com]

    Missing: Hypertrichosis of Eyebrows
  • Hodgkin Lymphoma

    A 30-year-old lady presented with fever, dry cough and weight loss for the preceding five months.[ncbi.nlm.nih.gov] gene.[ncbi.nlm.nih.gov] An 80-year-old man was admitted to hospital with low-grade fever, weight loss, asthenia and anorexia.[ncbi.nlm.nih.gov]

    Missing: Hypertrichosis of Eyebrows
  • Myeloproliferative Disease

    Splenomegaly, hepatomegaly as well as fatigue, malaise or weight loss may appear in advanced stages.[orpha.net] Many of these gene mutations figure importantly in the revised WHO classification.[doi.org] The clinical picture in early stages is often nonspecific with symptoms including fatigue, weight loss and anorexia.[symptoma.com]

    Missing: Hypertrichosis of Eyebrows

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