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2,628 Possible Causes for Hypertrophic Osteoarthropathy, Pancytopenia, Polyclonal Hyperglobulinemia

  • HIV Infection

    […] osteomalacia* Protease inhibitors with statins: myopathy Hematologic or oncologic Anemia of chronic disease Lymphoma, multiple myeloma Bone marrow infiltration (leading to pancytopenia[aafp.org] Hyperactivation is reflected in dramatic polyclonal hyperglobulinemia, only a portion of which is directed against HIV antigens;(59) bone marrow plasmacytosis;(60) heightened[hivinsite.ucsf.edu] Pancytopenia is not uncommon in advanced AIDS and bone marrow biopsies often reveal evidence of hypoplasia.[hivinsite.ucsf.edu]

  • Primary Myelofibrosis

    This is then followed by pancytopenia (a reduction in the number of red and white blood cells, as well as platelets).[aoporphan.com] Osteosclerosis, hypertrophic osteoarthropathy and periostitis: may cause severe joint and bone pain.[patient.info] Polyclonal hyperglobulinemia may be present. Patients with sporadic idiopathic or familial pulmonary hypertension have significant marrow fibrosis.[patient-help.com]

  • Chronic Active Hepatitis

    Abstract A 28-year-old man was admitted to our department with intermittent fever, hepatosplenomegaly and pancytopenia.[ncbi.nlm.nih.gov] hyperglobulinemia.[hepatitiscentral.com] Additionally, some authorities require the presence of immunologic features, particularly high titers (usually more than 1:40) of certain non organic specific autoantibodies and polyclonal[hepatitiscentral.com]

  • Small-Cell Carcinoma of the Lung

    He developed pancytopenia.[jmedicalcasereports.com] In almost all reported cases, hypertrophic pulmonary osteoarthropathy was observed in all patients with non-small cell lung carcinoma.[ncbi.nlm.nih.gov] osteoarthropathy and digital clubbing Associated with NSCLC , especially the adenocarcinoma type Periosteal proliferation of the tubular bones characterized by (i) painful[pathophys.org]

    Missing: Polyclonal Hyperglobulinemia
  • Macronodular Cirrhosis

    There can be pancytopenia due to hypersplenism in portal hypertension, impaired coagulation, disseminated intravascular coagulation, and hemosiderosis in patients with cirrhosis[ncbi.nlm.nih.gov] It is not specific for cirrhosis and can therefore be due to a number of conditions [18] Hypertrophic osteoarthropathy.[en.wikipedia.org] Nail changes: Clubbing, hypertrophic osteoarthropathy, and the Dupuytren contracture are seen.[ncbi.nlm.nih.gov]

    Missing: Polyclonal Hyperglobulinemia
  • Multicentric Castleman's Disease

    Diffuse lymph-node enlargement, splenomegaly and pancytopenia were detected. Induction with Rituximab was made because pancytopenia was present.[ncbi.nlm.nih.gov] hyperglobulinemia, elevated transaminases and renal disease. 2 , 5 , 7 Dispenzieri et al. 8 analyzed the clinical spectrum of Castleman’s disease in 113 patients.[pagepress.org] Abstract An HIV positive black African woman presented with widespread lymphadenopathy and pancytopenia that had been ascribed to tuberculosis.[ncbi.nlm.nih.gov]

    Missing: Hypertrophic Osteoarthropathy
  • Secondary Myelofibrosis

    We concluded that the pancytopenia was because of bone marrow fibrosis resulting from primary hyperparathyroidism.[ncbi.nlm.nih.gov] Osteosclerosis, hypertrophic osteoarthropathy and periostitis: may cause severe joint and bone pain.[patient.info] Osteosclerosis, hypertrophic osteoarthropathy, and periostitis may occur, resulting in significant pain and discomfort.[emedicine.medscape.com]

    Missing: Polyclonal Hyperglobulinemia
  • Autosomal Recessive Pachydermoperiostosis 

    […] as patient 2, have been described as having more severe symptoms overall 6, 9, 11, the presence of skin folds (as cutis verticis gyrata ) 5, 12, and chronic anemia and/or pancytopenia[jrheum.org] osteoarthropathy Hypertrophic osteoarthropathy, primary PHO pachydermoperiostosis Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, type 1 PHOAR1 PDP HYPERTROPHIC[wikidata.org] (HLA) B12 has been shown in one study of this syndrome. [39] Tanaka et al reported pulsed steroid therapy with parenteral iron having been able to improve the anemia and pancytopenia[emedicine.medscape.com]

    Missing: Polyclonal Hyperglobulinemia
  • Autosomal Recessive Osteopetrosis Type 7

    […] onset, features may includefractures, short stature, compressive neuropathies (pressure on the nerves), hypocalcemia with attendant tetanic seizures ,and life-threatening pancytopenia[monarchinitiative.org] Osteoarthropathy (NGS panel of 22 genes)[cgcgenetics.com] […] onset, features may include fractures, short stature, compressive neuropathies (pressure on the nerves), hypocalcemia with attendant tetanic seizures, and life-threatening pancytopenia[malacards.org]

    Missing: Polyclonal Hyperglobulinemia
  • Paraneoplastic Syndrome

    After failure of intravenous immunoglobulin and high-dose steroids to control PNS and despite pancytopenia from chemotherapy, very aggressive surgical resection was life saving[ncbi.nlm.nih.gov] Von Willebrand factor antigen in hypertrophic osteoarthropathy . J. Rheumatol. 19 , 765–767 (1992). 21. Silveri, E. et al .[nature.com] Pancytopenia with a hypercellular bone marrow as a possible paraneoplastic syndrome. Am. J. Hematol. 19, 205–206 (1985). 37. Cooper, D. L., Sandler, A. B., Wilson, L.[doi.org]

    Missing: Polyclonal Hyperglobulinemia

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