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15 Possible Causes for Hyperuricemia, Intermittent Jaundice, Uric Acid Increased

  • Hereditary Spherocytosis

    Abstract Hereditary spherocytosis is an autosomal dominant congenital hemolytic anemia due to defect in RBC membrane protein that commonly presents with intermittent jaundice[ncbi.nlm.nih.gov] Dubin-Johnson syndrome is a chronic, benign, intermittent jaundice, mostly of conjugated hyperbilirubinemia.[ncbi.nlm.nih.gov] Fatigue is associated with intermittent jaundice.[explainmedicine.com]

  • Hepatorenal Syndrome

    Wui-Chiang Lee, Han-Chieh Lin, Ming-Chih Hou, Hsiao-Yi Lin, Fa-Yauh Lee, Sun-Sang Wang, Full-Young Chang and Shou-Dong Lee , Serum Uric Acid Levels in Patients With Cirrhosis[doi.org] Severe circulatory dysfunction (mean arterial pressure usually is 70 mm Hg) and very low systemic vascular resistance. • Severe liver disease, with jaundice, coagulopathy,[scielo.mec.pt] Jens H Henriksen, Søren Møller, Søren Schifter and Flemming Bendtsen , Increased arterial compliance in decompensated cirrhosis , Journal of Hepatology , 10.1016/S0168-8278[doi.org]

  • Renal Impairment

    BACKGROUND AND OBJECTIVE: Verinurad (RDEA3170) is a high-affinity, selective URAT1 transporter inhibitor in development for treating gout and asymptomatic hyperuricemia.[ncbi.nlm.nih.gov] […] in uric acid excretion, serum creatinine, or BUN.[hyper.ahajournals.org] Abstract Benign recurrent intrahepatic cholestasis (BRIC) is a rare autosomal recessive condition characterized by intermittent episodes of pruritus and jaundice that may[ncbi.nlm.nih.gov]

  • Hemolytic Anemia due to a Disorder of Glycolytic Enzymes

    HGPRT (converts hypoxanthine to IMP and guanine to GMP) X-linked recessive leads to excess uric acid production Findings include retardation, self mutilation, aggression, hyperuricemia[quizlet.com] However, inosine, which is a naturally occurring substance, increases plasma uric acid levels ( 38 ).[nature.com] jaundice and episodes of red/ dark urine Venous thrombosis in unusual locations (e.g., hepatic, cerebral, abdominal veins) Vasoconstriction : headache, pulmonary hypertension[amboss.com]

  • Glucose-6-Phosphate Dehydrogenase Deficiency

    Pubmed and Google Scholar using the following key words: "methemoglobinemia", "rasburicase", "urate oxidase", tumor lysis syndrome", G6PD deficiency", "hemolytic anemia" and "hyperuricemia[ncbi.nlm.nih.gov] An acid urine pH favors production of poorly soluble uric acid over the more soluble urate, increasing the risk for precipitation of intratubular uric acid crystals.[cjasn.asnjournals.org] To determine whether you have an inherited G6PD deficiency When a child experienced persistent jaundice as a newborn for unknown reasons; when you have had one or more intermittent[labtestsonline.org]

  • Periodic Sialadenosis

    These patients had a history of regular strenuous exercising and prolonged or periodic starvation, in the absence of other potential causes for the hyperuricemia, i.e., dehydration[researchgate.net] Gilbert’s Syndrome was first described in 1901 as a syndrome of chronic benign intermittent jaundice in the absence of other liver PERSONAL: Gilberts Web Forums.[mosquito-fp7.eu] Increased net degradation of cellular adenosine triphosphate during strenuous exercising and decreased renal clearance of uric acid during starvation were the most likely[researchgate.net]

  • Hexokinase Deficiency

    […] phosphate is shunted into alternative pathways resulting in 3 major metabolic consequences: [2] Hyperlacticacidemia, which develops as a byproduct of enhanced glycolysis Hyperuricemia[online.epocrates.com] Uric Acid), and the patient presents Hyperuricemia.[biochemistryquestions.wordpress.com] Intermittent jaundice and premature pigment gallstones are common. Splenomegaly is characteristic (palpable in 75% to 80% of cases).[web.archive.org]

  • Tyrosinemia

    […] obstructive cardiomyopathy 肥大型閉塞性心筋症 HOCM hypertrophic pyloric stenosis 肥厚性幽門狭窄/肥厚性幽門狭窄症 HPS hypertrophy 肥大/肥厚/栄養過度 hypertyrosinemia 高チロシン血症 hypertyrosinemia type I 高チロシン血症I型 hyperuricemia[jpeds.or.jp] The tubular handling of phosphorus, uric acid, beta 2-microglobulin, and amino acids was disturbed. Low urinary osmolality was also seen.[ncbi.nlm.nih.gov] The acute onset may be dramatic, with hepatomegaly, jaundice, epistaxis, melaena, purpuric lesions, marked oedema, and the distinctive cabbage-like odour.[patient.info]

  • Beta-Ureidopropionase Deficiency

    Novel PRPS1 gain-of-function mutation in a patient with congenital hyperuricemia and facial anomalies Ingår i American Journal of Medical Genetics.[kemi.uu.se] Plasmodium falciparum (malaria parasite) Along with many other disease causing parasites -Juvenile gout -No salvage of purines, therefore causing an increase in uric acid[quizlet.com] Intellectual disability, seizures, and periodic loss of balance and coordination (intermittent ataxia).[metascreen.vn]

  • Ethambutol

    […] with phenytoin may increase phenytoin levels No alcohol Pyrazinamide Pharmacokinetics Pyrazinamide Side effects photosensitivity, n/v idarrhea, anorexia, liver toxicity, hyperuricemia[quizlet.com] Alanine aminotransferase, aspartate aminotransferase, bilirubin, uric acid: increased levels Glucose: decreased level Patient monitoring Watch for serious adverse reactions[medical-dictionary.thefreedictionary.com] A trial of intermittent rifampin and ethambutol in retreatment regimens. Scand J Respir Dis Suppl 1973; 84: 132-5.[livertox.nih.gov]

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