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309 Possible Causes for Hyperuricemia, Progressive Polyneuropathy

  • Chronic Alcoholism

    Cardiovascular system: Holiday heart syndromes Dilatative cardiomyopathy caused by alcoholism Arterial hypertension Apoplexy Coronary heart disease Metabolism : Hypertriglyceridemia Hyperuricemia[flexikon.doccheck.com]

  • Diabetes Mellitus

    Fructose is also the only sugar able to increase blood uric acid concentrations, and SSB consumption has been linked to development of hyperuricemia (serum uric acid level[doi.org] Hypothesis: fructose-induced hyperuricemia as a causal mechanism for the epidemic of the metabolic syndrome. Nat Clin Pract Nephrol. 2005 ; 1 : 80–86.[doi.org] After 10 years, the group undergoing surgery had statistically lower weight and less diabetes, hypertriglyceridemia, and hyperuricemia, but not less hypertension or hypercholesterolemia[clinical.diabetesjournals.org]

  • Multiple Myeloma

    […] to multiple myeloma The initial presentation occasionally is a polyneuropathy when it is part of a POEMS syndrome (mostly the sclerotic form).[radiopaedia.org] Not recognizing hyperuricemia.[clinicaladvisor.com] Trial-ineligibility was determined by presence of at least one of the common exclusion criteria: heart/renal failure, liver/renal diseases, polyneuropathy, HIV positivity.[ncbi.nlm.nih.gov]

  • Pernicious Anemia

    A 81-year-old woman was diagnosed as having diabetes mellitus (DM) at 58 years of age. She started insulin therapy the following year, but her blood sugar levels were poorly controlled. At the age of 75, she tested positive for the anti-GAD antibody (7.8 U/ml) and was diagnosed as having slowly progressive type 1[…][ncbi.nlm.nih.gov]

  • Waldenstrom Macroglobulinemia

    Neuropathy is typically slowly progressive, distal, symmetrical, and sensorimotor.[emedicine.medscape.com] POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes) also may be associated with Waldenström macroglobulinemia.[emedicine.medscape.com]

  • Hyperuricemia

    It is also the leading cause for hyperuricemia leading to gout.[symptoma.com] The patient developed progressive peripheral neuropathy in additon to his profound mental retardation and self-injurious behavior.[ncbi.nlm.nih.gov] Hyperuricemia is described as an increased concentration of uric acid in blood.[ncbi.nlm.nih.gov]

  • Occult Malignancy

    ARF presenting with hyperkalemia, hyperuricemia and hyperphosphatemia should lead to further work up for occult haematological malignancy.[ncbi.nlm.nih.gov]

  • Vasculitis

    Neuropathy Sensory or Sensory-Motor General patterns Mononeuritis multiplex (13%) Asymmetric polyneuropathy (85%) Distal symmetric polyneuropathy (2%) More slowly progressive[neuromuscular.wustl.edu] With support from the National Institute of Arthritis and Musculoskeletal and Skin Diseases, we launched the UAB Center of Research Translation on Gout and Hyperuricemia.[uabmedicine.org] During his teenage years he developed metaboloic syndrome – hypertension, obesity, hyperuricemia, impaired glucose tolerance.[actarheuma.com]

  • Paraneoplastic Syndrome

    We report a fatal case of severe chronic progressive axonal polyradiculoneuropathy in association with this antibody.[doi.org] Patients have hyperuricemia when serum level of uric acid is above 8 mg/dL.[sjkdt.org] It is usually a distal sensorimotor polyneuropathy that causes mild motor weakness, sensory loss, and absent distal reflexes.[merckmanuals.com]

  • Myeloma-associated Amyloidosis

    The peripheral neuropathy of MGUS is classically bilateral, peripheral and sensory with electrophysiologic studies showing a demyelinating pattern; and in patients with progressive[hematology.org] Hypercalcemia and hyperuricemia can occur as a result of myeloma and can contribute to renal failure.[cancer.ucsf.edu] […] relationship between MGUS and peripheral neuropathy is supported by association of peripheral neuropathy with other plasma cell dyscrasias including WM, MM, AL amyloid and POEMS (polyneuropathy[hematology.org]

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