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527 Possible Causes for Hyperuricemia, Pruritus

  • Niacin

    However, the use of niacin can be complicated by the development of hepatotoxicity, hyperuricemia, and modest hyperglycemia.[ncbi.nlm.nih.gov] […] no longer outweigh the risks, and the approval for this indication should be withdrawn Overdose management Symptoms of acute overdose include flushing, GI distress, and pruritus[reference.medscape.com] Niacin can cause an excess of uric acid in the blood (hyperuricemia), putting you at risk of gout.[mayoclinic.org]

  • Polycythemia Vera

    The maximum-tolerated dose of gandotinib was 120mg daily, based on dose-limiting toxicities of blood creatinine increase or hyperuricemia at higher doses.[ncbi.nlm.nih.gov] Aquagenic pruritus is one of the main clinical features of polycythemia vera. The aim of this study was to analyse the clinical characteristics of aquagenic pruritus.[ncbi.nlm.nih.gov] Splenomegaly is relatively common, seen in approximately two-thirds of patients. 4 Hyperuricemia (from increased cell turnover) and gout are also associated with polycythemia[mdedge.com]

  • Non-Hodgkin Lymphoma

    Tumor lysis syndrome is heralded by the development of hypocalcemia, hyperkalemia, hyperphosphatemia and hyperuricemia, as well as acute renal failure; consult nephrology[clinicaladvisor.com] Common examples are follicular lymphoma and marginal zone lymphoma.Few subtypes of Non-Hodgkin lymphoma may also present with rash, pruritus, generalized aches and pains.[symptoma.com]

  • Multiple Myeloma

    Not recognizing hyperuricemia.[clinicaladvisor.com] Her pruritus resolved, but the lesions persisted. Footnotes Competing interests: None declared. This article has been peer reviewed.[cmaj.ca] Diagnoses of hyperuricemia, hypercalcemic nephropathy, glomerulosclerosis, and light-chain nephropathy are also possible.[symptoma.com]

  • Chronic Kidney Insufficiency

    Charnow, Editor October 26, 2018 Patients with chronic kidney disease who have hyperuricemia have a 3-fold higher risk of all-cause mortality.[renalandurologynews.com] In fact, drowsiness, fatigue, and an overall lack of energy are encountered in the majority of patients, along with pruritus and pain.[symptoma.com] Symptoms develop slowly and in advanced stages include anorexia, nausea, vomiting, stomatitis, dysgeusia, nocturia, lassitude, fatigue, pruritus, decreased mental acuity,[merckmanuals.com]

  • Myeloproliferative Disease

    […] leukemia and agnogenic myeloid metaplasia Easy bruising, bleeding, and/or symptoms of thrombosis Swollen, painful joint(s) secondary to gouty arthritis that is secondary to hyperuricemia[emedicine.medscape.com] Common symptoms include: headaches blurred vision fatigue weakness dizziness itchiness (pruritus) night sweats raised blood pressure (hypertension).[leukaemia.org.au] […] neoplasms include the following: Easy fatigability Easy bruising, bleeding, and/or symptoms of thrombosis Swollen, painful joint(s) secondary to gouty arthritis secondary to hyperuricemia[emedicine.medscape.com]

  • Acute Kidney Failure

    Mild hyperuricemia, as a result of decreased renal uric acid excretion, is common in AKI.[renalandurologynews.com] Symptoms may include: Appetite loss General ill feeling and fatigue Headaches Itching ( pruritus) and dry skin Nausea Weight loss without trying to lose weight Symptoms that[mountsinai.org] […] present) TABLE 1 Key Symptoms and Physical Findings in Patients with Acute Renal Failure and Uremia* Symptoms Anorexia Fatigue Mental status changes Nausea and vomiting Pruritus[aafp.org]

  • Acute Fatty Liver of Pregnancy

    […] diagnosis (based on Swanseas criteria),the patient must have at least 6 of the following symptoms:nausea, abdominal pain, polydipsia/polyuria, encephalo-pathy, hypoglycemia, hyperuricemia[vdocuments.site] The pruritus, however, persisted despite the premature delivery of a normal newborn at the 35th week.[ncbi.nlm.nih.gov] Polydipsia (in nine episodes) and skin pruritus (in seven episodes) were unusual clinical findings.[ncbi.nlm.nih.gov]

  • Psoriasis

    Psoriatic patients had higher levels of serum uric acid (6.25 1.62 vs 5.71 1.35 mg/dl; P 0.019) and significantly greater prevalence of hyperuricemia (31.6% vs 16.2%; P 0.009[ncbi.nlm.nih.gov] The mediators involved in psoriatic pruritus have not been fully established.[ncbi.nlm.nih.gov] Therefore, it is important to periodically investigate uric acid levels in order to treat changes triggered by hyperuricemia.[ncbi.nlm.nih.gov]

  • Leukemia

    Other laboratory findings may include hyperuricemia, hyperphosphatemia, hyperkalemia or hypokalemia, hypocalcemia, elevated serum hepatic transaminases or LDH, hypoglycemia[merckmanuals.com] […] factors) Special considerations apply to the treatment of the following: Burkitt leukemia Ph ALL ALL in older children and younger adults Relapsed ALL ALL in patients with hyperuricemia[emedicine.medscape.com] Hydration (twice the daily maintenance volume), urine alkalinization (pH 7 to 8), and electrolyte monitoring can prevent the hyperuricemia, hyperphosphatemia, hypocalcemia[merckmanuals.com]

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