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175 Possible Causes for Hyperuricemia, Pruritus, Splenomegaly

  • Non-Hodgkin Lymphoma

    Computed tomography scan of the chest and abdomen showed paratracheal and subcarinal lymphadenopathy and splenomegaly, with the findings being compatible with lymphoma.[ncbi.nlm.nih.gov] Tumor lysis syndrome is heralded by the development of hypocalcemia, hyperkalemia, hyperphosphatemia and hyperuricemia, as well as acute renal failure; consult nephrology[clinicaladvisor.com] Common examples are follicular lymphoma and marginal zone lymphoma.Few subtypes of Non-Hodgkin lymphoma may also present with rash, pruritus, generalized aches and pains.[symptoma.com]

  • Polycythemia Vera

    […] symptoms in the phase 3 RESPONSE study of patients with polycythemia vera with splenomegaly who experienced an inadequate response to or adverse effects from hydroxyurea.[ncbi.nlm.nih.gov] The maximum-tolerated dose of gandotinib was 120mg daily, based on dose-limiting toxicities of blood creatinine increase or hyperuricemia at higher doses.[ncbi.nlm.nih.gov] A detailed MEDLINE search for all English language articles related to PV, PV-associated pruritus and aquagenic pruritus that were published from 1965 till date was carried[ncbi.nlm.nih.gov]

  • Myeloproliferative Disease

    CML: demonstrates increased production of neutrophils and marked splenomegaly.[ncbi.nlm.nih.gov] […] leukemia and agnogenic myeloid metaplasia Easy bruising, bleeding, and/or symptoms of thrombosis Swollen, painful joint(s) secondary to gouty arthritis that is secondary to hyperuricemia[emedicine.com] Common symptoms include: headaches blurred vision fatigue weakness dizziness itchiness (pruritus) night sweats raised blood pressure (hypertension).[leukaemia.org.au]

  • Leukemia

    Five features were present in 50% of children: hepatomegaly (64%), splenomegaly (61%), pallor (54%), fever (53%) and bruising (52%).[ncbi.nlm.nih.gov] Hyperuricemia and a slightly raised lactate dehydrogenase (LDH) are common features.[web.archive.org] […] leukemia (T-PLL) is the most common type of mature T-cell leukemia and is characterized by a rapidly rising peripheral blood lymphocyte count, bone marrow involvement, and splenomegaly[web.archive.org]

  • Hodgkin's Disease

    The presenting feature common in all cases was superficial lymphadenopathy followed by hepatomegaly in 17 (20%) cases and splenomegaly in 16 (19%).[ncbi.nlm.nih.gov] She remained with a low level of pruritus until her death in July 2008, at the same dose of thalidomide.[ncbi.nlm.nih.gov] Abdomen: Abdominal enlargement may be noted with splenomegaly or hepatomegaly.[symptoma.com]

  • Waldenstrom Macroglobulinemia

    Abstract Manifestations of macroglobulinemic lymphoma include lymphadenopathy, splenomegaly and bone marrow involvement.[ncbi.nlm.nih.gov] The presence of progressive, symptomatic lymphadenopathy or splenomegaly provide additional reasons to begin therapy. The presence of anemia with a hemoglobin value of[ncbi.nlm.nih.gov] CT-identified splenomegaly was reported in 6 of the 31 patients at baseline.[onclive.com]

  • Hereditary Spherocytosis

    Due to the membrane defect, there is increased fragility, hemolytic anemia, marked splenomegaly and hyperbilirubinemia.[ncbi.nlm.nih.gov] A 18 year old Turkish patient with hereditary spherocytosis was admitted to hospital with pruritus and severe jaundice.[ncbi.nlm.nih.gov] MATERIALS AND METHODS: A retrospective review was conducted to evaluate all SILS for splenomegaly performed by a single surgeon.[ncbi.nlm.nih.gov]

  • Primary Myelofibrosis

    We report a patient with very advanced myelofibrosis and huge splenomegaly who showed a complete hematological response to low dose thalidomide with reversal of splenomegaly[ncbi.nlm.nih.gov] The mechanism of chronic hyperuricemia in our case might be rapid cell turnover due to ineffective erythropoiesis of PMF.[ncbi.nlm.nih.gov] KEYWORDS: JAK inhibitors; Primary myelofibrosis; Pruritus; Treatment options[ncbi.nlm.nih.gov]

  • Acute Kidney Failure

    […] essential thrombocythemia, and primary myelofibrosis / Ayalew Tefferi -- Leukocytosis and leukopenia / Nancy Berliner -- Approach to the patient with lymphadenopathy and splenomegaly[worldcat.org] Mild hyperuricemia, as a result of decreased renal uric acid excretion, is common in AKI.[renalandurologynews.com] Symptoms may include: Appetite loss General ill feeling and fatigue Headaches Itching ( pruritus) and dry skin Nausea Weight loss without trying to lose weight Symptoms that[mountsinai.org]

  • Hepatitis

    Dehydration with drying of mucous membranes Telangiectasis (spider angiomata) and esophageal varices Jaundice Ascites Utricarial rashes Portal Hypertension Hepatomegaly and Splenomegaly[symptoma.com] Other biochemical and hematologic parameters often seen during AH include hypokalemia, hypomagnesemia, hyperuricemia, hypertriglyceridemia, and hyperferritinemia[ 17 ].[doi.org] The adverse events observed in the control group encompassed pruritus (11 patients), cephalea (four patients), and nausea and epigastric discomfort (one patient).[doi.org]

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