Possible Causes for hyperuricosuria Hyperuricemia We describe an infant with transient renal insufficiency associated with hyperuricemia, hyperuricosuria and increased echogenicity of the renal medullary pyramids. [ncbi.nlm.nih.gov] This response occurs in patients with SCA, but during the third decade of life hyperuricosuria can be reduced, probably by damage to the renal tubules caused by infarction [ncbi.nlm.nih.gov] Severe hyperuricosuria and intratubular uric acid precipitation result. [ncbi.nlm.nih.gov] Nephrolithiasis CONCLUSION: The most frequent metabolic alterations in females were hypocitraturia, urinary tract infection, low urinary volume and hyperuricosuria. [ncbi.nlm.nih.gov] We also found that 24.6% were obese (BMI 30 kg/m2) and showed higher rates of hypertension, DM, hyperlipidemia, hyperuricemia and hyperuricosuria compared with non-obese patients [ncbi.nlm.nih.gov] […] stones (struvite /-apatite and calcium oxalate) than in patients with pure infected stones (struvite /-carbonate apatite): hypercalciuria in 40%, hyperoxaluria in 34% and hyperuricosuria [ncbi.nlm.nih.gov] Urolithiasis Metabolic work-up revealed only normouricemic hyperuricosuria (HU) as the single identifiable risk factor for urolithiasis (UL) in these infants. [ncbi.nlm.nih.gov] Important metabolic risk factors are hypocitraturia in 63-87%, hyperoxaluria in 40-43%, hypocalciuria in 20%, hyperuricosuria in 27%, hyperammonuria in 11-51% and hypovolemia [ncbi.nlm.nih.gov] Generally, stones provoke considerable morbidity; hyperuricosuria is associated with an unusually severe stone disease. [jamanetwork.com] Urate Kidney Stone […] acidic) Maintain Urine pH 5.5 (6.5 - 7.0 preferred) Potassium Citrate 10-20 mEq orally three times daily with meals Calcium Citrate 500 mg, two tablets daily with meals Hyperuricosuria [fpnotebook.com] Hyperuricosuria when present increases the risk of calcium oxalate stone formation in 10-20% of the patients 3. [jpma.org.pk] Interestingly hyperuricosuria is also associated with increased calcium containing stone formation and is thought to be related to the uric acid crystals acting as a nidus [radiopaedia.org] Lesch-Nyhan Syndrome We report on a 16-day-old male with metabolic acidosis, hyperuricemia, hyperuricosuria, and nephrocalcinosis caused by Lesch-Nyhan syndrome. [ncbi.nlm.nih.gov] The Lesch-Nyhan syndrome is an x-linked defect of purine metabolism resulting in its classical form in major neurodevelopmental abnormality, hyperuricaemia, and hyperuricosuria [ncbi.nlm.nih.gov] […] sex-linked disorder of purine metabolism that is caused by a mutation in the hypoxanthine-guanine phosphoribosyltransferase (HPRT) gene which causes marked hyperuricemia and hyperuricosuria [ncbi.nlm.nih.gov] Idiopathic Hypercalcuria Abstract Two hundred two recurrent calcium oxalate stone-forming patients with idiopathic hypercalciuria or hyperuricosuria, or both, were treated for an average of 2.91 years [annals.org] Allopurinol can be helpful in patients with hyperuricosuria, and urease inhibitors can help break the cycle of infectious calculi. [aafp.org] Ca-nephrolithiasis with idio-pathic hypercalciuria (IHC), and allopurinol (200 300mg/D) was also added to eight of these patients for the associated hyperuricemia and/or hyperuricosuria [webview.isho.jp] Hyperuricosuria The association of oliguria with hyperuricosuria is often overlooked. [ncbi.nlm.nih.gov] […] excess of urates or uric acid in the urine. hyperuricosuria [hi′peru′rĭkosu′re·ä or re·ə] hyperuricosuria an excess of uric acid in the urine. [medical-dictionary.thefreedictionary.com] The hyperuricosuria is most commonly due to an excessively purine-rich diet; however, hyperuricosuria may be related to overproduction of uric acid in as many as 30% of these [emedicine.com] Chronic Gouty Nephropathy […] nephropathy (UAN) Synonyms Urate nephropathy, gouty nephropathy with tophi, gout nephropathy Definitions Intrarenal precipitation of uric acid associated with hyperuricemia or hyperuricosuria [basicmedicalkey.com] Secondary hyperuricosuria: Primary gout, excessive purine intake, tubular ... [doctor-beller.dipmap.com] AUAN, also acute urate nephropathy ) is a rapidly worsening (decreasing) kidney function ( renal insufficiency ) that is caused by high levels of uric acid in the urine ( hyperuricosuria [en.wikipedia.org] Medullary Sponge Kidney […] patients with MSK, we report a 5-year-old girl with MSK who had features of both dRTA (nephrocalcinosis, hypercalciuria, hypocitraturia) and proximal tubular dysfunction (hyperuricosuria [ncbi.nlm.nih.gov] These patients constituted 7.3% of our calcium stone-forming population Metabolic anomalies (hypercalciuria, hyperoxaluria, hypocitraturia and hyperuricosuria) were observed [ncbi.nlm.nih.gov] Hyperuricosuria occurred together with hypercalciuria in five patients. [ncbi.nlm.nih.gov] Renal Colic Chemotherapy Disease of the small intestine Gout (type of arthritis caused by a buildup of uric acid in the joints) Hypercalciuria (excess calcium in the urine) Hyperuricosuria [slideshare.net] […] intestine Inflammatory bowel disease, Crohn’s disease or ulcerative colitis Gout Chemotherapy Excess calcium in the urine or hypercalciuria Excess uric acid in the urine or hyperuricosuria [home-remedies-for-you.com] Classically, uric acid stones are seen in patients with gout who have hyperuricaemia and, therefore, hyperuricosuria. [app.pulsenotes.com] Renal Pelvic Calculus Interestingly hyperuricosuria is also associated with increased calcium containing stone formation and is thought to be related to the uric acid crystals acting as a nidus [radiopaedia.org] Hyperuricosuria contributes to both calcium oxalate and uric acid stones. [auanet.org] Hyperuricosuria: Elevated level of uric acid in the urine. Hyperoxaluria: Elevated level of oxalate in the urine. Hypernatriuria: Elevated level of sodium in the urine. [effectivehealthcare.ahrq.gov] Tumor Lysis Syndrome Acute uric acid nephropathy (AUAN) due to hyperuricosuria has been a dominant cause of acute kidney failure but with the advent of effective treatments for hyperuricosuria [en.wikipedia.org] […] not limited to): tetany sudden mental incapacity, including emotional lability Parkinsonian (extrapyramidal) movement disorders papilledema myopathy Hyperuricemia[4] and hyperuricosuria [en.wikipedia.org] Interstitial Nephritis Allopurinol Aristolochic acid † Captopril Cimetidine Interferon alfa Lansoprazole Mesalamine Omeprazole Ranitidine Metabolic disorders Hyperoxalaturia Ethylene glycol poisoning Hyperuricosuria [merck.com] […] uropathy Reflux nephropathy* Mesoamerican nephropathy§ –– Metabolic Chronic hypokalemia Cystinosis Fabry disease Hypercalcemia, hypercalciuria Hyperoxaluria Hyperuricemia*, hyperuricosuria [msdmanuals.com] […] uropathy Reflux nephropathy * Mesoamerican nephropathy § –– Metabolic Chronic hypokalemia Cystinosis Fabry disease Hypercalcemia, hypercalciuria Hyperoxaluria Hyperuricemia*, hyperuricosuria [merck.com] Staghorn Calculus Of 22 patients who underwent metabolic evaluation, nearly 70% had a demonstrable metabolic abnormality including hypercalciuria, hypocitraturia, hypomagnesuria, and hyperuricosuria [scielo.br] […] hypercalciuria (idiopathic, 50%), hypercalcemia (infants may have high Vitamin D levels, Iran J Kidney Dis 2012;6:186 ), hyperoxaluria (in vegetarians with oxalate rich diet), hyperuricosuria [pathologyoutlines.com] Allopurinol can be helpful in patients with hyperuricosuria, and urease inhibitors can help break the cycle of infectious calculi. [aafp.org] Cystinuria A randomized, controlled trial of allopurinol in patients with hyperuricosuria and normocalciuria was also effective in preventing recurrent stones. [ncbi.nlm.nih.gov] Sakhaee (9) found that 5 of 27 cystinurics had hypercalciuria, 6 had hyperuricosuria, and 12 had hypocitraturia. [hdcn.com] Ling on hyperuricosuria. [ncbi.nlm.nih.gov] Fanconi Renotubular Syndrome Fanconi syndrome was suggested by multiple proximal tubular defects including renal glucosuria, hyperuricosuria, hyperphosphaturia, proximal renal tubular acidosis, and kaliuresis [ncbi.nlm.nih.gov] […] hypokalemia (1.6 mmol/L) with renal K wasting, hyperchloremic metabolic acidosis with positive urine anion gap, hypophosphatemia with hyperphosphaturia, hypouricemia with hyperuricosuria [ncbi.nlm.nih.gov] […] proteinuria, profound hypokalemia, hyperchloremic metabolic acidosis with a normal anion gap, positive urine anion gap, hypophosphatemia with hyperphosphaturia, hypouricemia with hyperuricosuria [ncbi.nlm.nih.gov] Ureterolithiasis In hyperuricosuria, intake of animal protein should be reduced. If the diet cannot be changed, allopurinol 300 mg each morning lowers uric acid production. [msdmanuals.com] However, all had hyperuricosuria of 800 mg in 24 h. [njcponline.com] Mild hyperuricosuria, defined as urinary uric acid 800 mg/day ( 5 mmol/day) in men or 750 mg/day ( 4 mmol/day) in women, is almost always caused by excess intake of purine [msdmanuals.com] Distal Renal Tubular Acidosis […] patients with MSK, we report a 5-year-old girl with MSK who had features of both dRTA (nephrocalcinosis, hypercalciuria, hypocitraturia) and proximal tubular dysfunction (hyperuricosuria [ncbi.nlm.nih.gov] […] investigations revealed proximal tubular dysfunction (low molecular weight proteinuria, generalized hyperaminoaciduria, hypophosphatemia with hyperphosphaturia, and hypouricemia with hyperuricosuria [ncbi.nlm.nih.gov] Hypercalciuria, hypocitraturia, and abnormally alkaline urine (and less frequently, hyperuricosuria) are situations that predispose the patient to the development of nephrolithiasis [revistanefrologia.com] Gout Uricosuric agents can cause hyperuricosuria, a risk factor for nephrolithiasis and acute uric acid nephropathy. [ncbi.nlm.nih.gov] In overproducers, restarting ULTs following drug holidays of more than 5 days leads to over 60% of patients experiencing hyperuricosuria. [ncbi.nlm.nih.gov] The aims of the present study were to simulate the relationship between suboptimal drug adherence and efficacy, and to quantify the risk of hyperuricosuria in gout patients [ncbi.nlm.nih.gov] Cholelithiasis […] older age, female sex, metabolic syndrome, liver diseases, specific diet and drugs for cholelithiasis and male sex, metabolic syndrome, reduced urinary volume and urine pH, hyperuricosuria [journals.plos.org] Gouty Arthritis […] subcutaneous tophaceous deposits) and specific radiological (assymetrical erosions with sclerotic margins and overlying edges) and laboratory findings (hyperuricemia and hyperuricosuria [ncbi.nlm.nih.gov] Renal Tubular Acidosis In addition, we found hyperuricosuria in 21 per cent of the patients with type I renal tubular acidosis with nephrolithiasis. [ncbi.nlm.nih.gov] Hypercalciuria, hypocitraturia, and abnormally alkaline urine (and less frequently, hyperuricosuria) are situations that predispose the patient to the development of nephrolithiasis [revistanefrologia.com] Acute Interstitial Nephritis Allopurinol Aristolochic acid † Captopril Cimetidine Interferon alfa Lansoprazole Mesalamine Omeprazole Ranitidine Metabolic disorders Hyperoxalaturia Ethylene glycol poisoning Hyperuricosuria [msdmanuals.com] […] uropathy Reflux nephropathy * Mesoamerican nephropathy § –– Metabolic Chronic hypokalemia Cystinosis Fabry disease Hypercalcemia, hypercalciuria Hyperoxaluria Hyperuricemia*, hyperuricosuria [msdmanuals.com] Amanita Phalloides Poisoning The results of pyrazinamide and probenecid tests performed in patients after A. phalloides poisoning indicated that hyperuricosuria was most likely due to an increment in [ncbi.nlm.nih.gov] Nephrocalcinosis […] hyperparathyroidism, sarcoidosis) Malabsorptive GI disorders (Crohn's, celiac sprue) Gout Family History Idiopathic hypercalciuria (multiple genes identified) Cystinuria (AR) Hyperuricosuria [quizlet.com] Patients with urate calculi have hyperuricosuria, but do not necessarily have hyperuricemia. [radiologykey.com] Metabolic work up was done using twenty-four hour urine sample which revealed hypercalciuria, hyperuricosuria, and reduced tubular reabsorption of phosphorus. [sjkdt.org] Tenosynovitis of the Wrist Gout is a disorder of urate metabolism in which the overproduction of uric acid causes hyperuricemia and hyperuricosuria. [musculoskeletalkey.com] Lower Urinary Tract Infection Known metabolic abnormalities that predispose to stone formation include hypercalciuria, hyperoxaluria, hypocitraturia, hyperuricosuria, cystinuria, and low urine volume. [auanet.org] Streptococcus Pneumoniae Of 22 patients who underwent metabolic evaluation, nearly 70% had a demonstrable metabolic abnormality including hypercalciuria, hypocitraturia, hypomagnesuria, and hyperuricosuria [scielo.br] […] malformations of the urinary tract associated with infection and also metabolic diseases such as cystinuria, renal tubular acidosis and alterations like hypercalciuria and hyperuricosuria [scielo.br] Hereditary Fructose Intolerance […] relaxed (from 10 to 250 mg per kilogram per day), neither boy had symptoms, hypoglycemia, or evidence of hepatic or renal dysfunction, but both had sustained hyperuricemia and hyperuricosuria [ncbi.nlm.nih.gov] Since the rate of formation of F1P is much faster than its further metabolism, this can lead to hyperuricemia and hyperuricosuria by the mechanisms described above. [namrata.co] […] hemorrhagic telangiectasia 遺伝性出血性末梢血管拡張症 hereditary hyperbilirubinemia 遺伝性高ビリルビン血症 hereditary hypersegmentation 遺伝性過分葉症 hereditary hyposegmentation 遺伝性低分葉症 hereditary metabolic hyperuricosuria [jpeds.or.jp] Pancreatic Insufficiency Hyperuricosuria due to high-dose pancreatic extract therapy in cystic fibrosis. N Engl J Med 1976; 295: 246–248. PubMed CrossRef Google Scholar 66. [link.springer.com] Extremely high doses of pancreatic extracts have been associated with hyperuricemia and hyperuricosuria[ 40 ]. [dx.doi.org] Therapeutic approach to pancreatic extract-induced hyperuricosuria in cystic fibrosis. J Pediatr 1977; 90: 302–305. PubMed CrossRef Google Scholar 67. [link.springer.com]
