Possible Causes for hyperviscosity Pyelonephritis Xanthogranulomatous pyelonephritis (XGP) is a well recognised but rare type of chronic pyelonephritis classically occurring in middle-aged women. It is increasingly being recognised in children in whom it can be mistaken for Wilms' tumour. Awareness of the possibility of this condition occurring in children may allow early[…] [ncbi.nlm.nih.gov] Dehydration Dehydration occurs when your body does not have as much water and fluids as it needs. Dehydration can be mild, moderate, or severe, based on how much of your body's fluid is lost or not replaced. Severe dehydration is a life-threatening emergency. You can become dehydrated if you lose too much fluid, do not[…] [nlm.nih.gov] Multiple Myeloma Hyperviscosity: Emergent plasmapheresis B. [clinicaladvisor.com] (Multiple Myeloma 와의 차이) Peripheral neuropathy, Organomegaly (hepatomegaly, splenomegaly, lymphadenopathy), Hyperviscosity syndrome (IgM 이 pentamer 이므로. [sondoctor.co.kr] Diuretic therapy should be avoided in patients with hyperviscosity. [cancertherapyadvisor.com] Leukemia The presence of glaucoma is known to be specific for the hyperviscosity syndrome. [web.archive.org] Paraneoplastic syndromes in malignant lymphomas manifest by anemia, hypercalcemia, blood hyperviscosity, cachexia and other less frequent forms. [web.archive.org] Multiple myeloma, complicated by hyperviscosity syndrome, was diagnosed by BUBLOT et al. (1985) in a 9-year-old dog showing on necropsy fluids in the cavities and moderate [web.archive.org] Waldenstrom Macroglobulinemia Because hyperviscosity syndrome can be lethal, it must be recognized and managed early. [ncbi.nlm.nih.gov] No manifestation of hyperviscosity syndrome was noted. Bone marrow biopsy disclosed the concurrent systemic involvement. [ncbi.nlm.nih.gov] Plasmapheresis should be considered for symptomatic hyperviscosity and for prophylaxis in patients in whom rituximab therapy is contemplated. [ncbi.nlm.nih.gov] Polycythemia Diagnosis of hyperviscosity syndrome is clinical. [msdmanuals.com] The elevated blood cell mass results in hyperviscosity, which is associated with slow blood flow and an increased risk of thrombosis. [amboss.com] Premature infants rarely develop hyperviscosity syndrome. [msdmanuals.com] Eisenmenger Syndrome Chronic hypoxia caused by Eisenmenger syndrome may result in polycythemia with resultant hyperviscosity and bilateral central retinal vein occlusion. [ncbi.nlm.nih.gov] Erythrocytosis is present in most patients, but excessive phlebotomy may cause microcytosis and exacerbate the symptoms of hyperviscosity. [annals.org] The hemostatic changes associated with the syndrome may lead to thromboembolic events, cerebrovascular complications, or the hyperviscosity syndrome. [annals.org] Systemic Lupus Erythematosus Systemic lupus erythematosus (SLE) is an autoimmune disease that affects many organs, but multisystem dysfunction is rare. Here, we report a case of a 29-year-old woman who was initially diagnosed with SLE complications including lupus nephritis, lupus encephalopathy, renal hypertension, thrombocytopenia, anaemia[…] [ncbi.nlm.nih.gov] Cystic Fibrosis As antimicrobial-resistant microbes become increasingly common and a significant global issue, novel approaches to treating these infections particularly in those at high risk are required. This is evident in people with cystic fibrosis (CF), who suffer from chronic airway infection caused by antibiotic resistant[…] [ncbi.nlm.nih.gov] Heavy Chain Disease Hyperviscosity. Nephrotic syndrome, cardiac failure, malabsorption. Peripheral neuropathies, carpal tunnel syndrome. [patient.info] Treatment of symptomatic patients includes chemotherapy and supportive therapy aimed at the correction of anaemia and hyperviscosity. Chronic lymphocytic leukaemia. [patient.info] Central Retinal Vein Occlusion We report in this article central retinal vein occlusion (CRVO) caused by hyperviscosity syndrome (HVS) in a young patient with mucosa-associated lymphoid tissue (MALT) lymphoma [ncbi.nlm.nih.gov] It can cause a hyperviscosity syndrome secondary to the paraproteinaemia associated with the disease. [ncbi.nlm.nih.gov] When a patient less than 50 years of age experiences central retinal vein occlusion, other mechanisms, such as the hyperviscosity syndrome or the inflammatory condition (inflammation [ncbi.nlm.nih.gov] Leukostasis The management includes hydration, cytoreduction, prevention of tumor lysis and, rarely, leukapheresis in cases complicated by leukostasis and hyperviscosity syndrome. [ncbi.nlm.nih.gov] Leukostasis is a reduction in blood flow related to hyperviscosity. [ncbi.nlm.nih.gov] Mortality is related to the underlying cause of the hyperviscosity syndrome. Stone MJ, Bogen SA. Evidence-based focused review of management of hyperviscosity syndrome. [emedicine.medscape.com] Cryoglobulinemia We describe the case of an HIV/HCV-infected patient with HCV-related chronic lymphoproliferative disease, mixed cryoglobulinemia and hyperviscosity syndrome. [ncbi.nlm.nih.gov] Waldenström's macroglobulinemia (WM) manifests as hyperviscosity syndrome. [ncbi.nlm.nih.gov] In the Brouet classification, type I cryoglobulinemia is caused by hyperviscosity, whereas type II and III manifestations are caused by vasculitis in target organs (primarily [ncbi.nlm.nih.gov] Polycythemia Vera Hyperviscosity syndrome was defined as having 2 or more hyperviscosity symptoms. [ncbi.nlm.nih.gov] The occurrence of myocardial infarction in myeloproliferative disease is mostly attributed to coronary thrombosis due to hyperviscosity and thrombocytosis. [ncbi.nlm.nih.gov] Polycythemia vera (PV) is a chronic myeloproliferative neoplasm that leads to hyperviscosity and the risk of thrombosis. [ncbi.nlm.nih.gov] Exchange Transfusion The objective of this study was to examine the use of partial exchange transfusion (PET) performed for polycythemia hyperviscosity syndrome (PHS) over time. [ncbi.nlm.nih.gov] Hyperviscosity of blood results in increased resistance to blood flow and decreased oxygen delivery. [ncbi.nlm.nih.gov] Cerebral arterial pulsatile flow changes and the effect of partial plasma exchange transfusion on these pulsatile flow patterns were studied in neonatal polycythemia/hyperviscosity [ncbi.nlm.nih.gov] Stress Polycythemia Since many aspects of hemorheology and hemodynamics are affected by disease or clinical states, these effects are discussed as are hyperviscosity syndromes, therapy for disturbed [books.google.com] The elevated blood cell mass results in hyperviscosity, which is associated with slow blood flow and an increased risk of thrombosis.. [amboss.com] […] comparative studies; Hemodynamics, covering basic principles, microcirculation, in vivo effects, endothelium and methods; and Clinical Aspects of Hemorheology, covering hyperviscosity [books.google.com] Secondary Polycythemia I would do a phlebotomy if he has signs/symptoms suggestive of hyperviscosity, and his hemoglobin is above 18... Tue Jun 06, 05:05:00 PM Jennings said... [pulmonaryroundtable.blogspot.com] Rarely seen under the age of 40 years The symptoms are due to: Hyperviscosity. Hypervolemia. Hypermetabolism. [labpedia.net] Uncomp (11) PCT 36 (19 - 74) Cyanotic CHD HCT 45% 57% vs. 69% Stroke 0% ‡ High-risk patients with hyperviscosity symptoms; long follow-up Phlebotomy at 3 - 6 months interval [ncbi.nlm.nih.gov] Idiopathic Cryoglobulinemia Cryoglobulinemia can also lead to small-vessel vasculitis, which can cause purpura; hyperviscosity and direct vascular trauma can contribute. [msdmanuals.com] multiple myeloma, lymphoma, Waldenström’s macroglobulinemia), and hyperviscosity syndrome, or it may be idiopathic (essential mixed cryoglobulinemia). [rheumaknowledgy.com] Marked elevations of other immunoglobulins (especially IgA and IgG3) can also be associated with a hyperviscosity syndrome. Click here for Patient Education [msdmanuals.com] Polycythemia Neonatorum The outlook is good for infants with mild hyperviscosity. Good results are also possible in infants who receive treatment for severe hyperviscosity. [medlineplus.gov] Abstract In clinical practice, neonatal polycythemia has been used as a marker for neonatal hyperviscosity, implicated as a cause of long-term neurologic delay and damage [ncbi.nlm.nih.gov] Neonatal polycythemia and hyperviscosity. Clin Perinatol. 1995 Sep. 22(3):693-710. [Medline]. Wirth FH, Goldberg KE, Lubchenco LO. Neonatal hyperviscosity: I. Incidence. [emedicine.medscape.com] Idiopathic Recurrent and Disabling Cutaneous Herpes Hyperviscosity syndrome Hyperviscosity syndrome is caused by a clinically significant increase in the viscosity of whole blood, which may result from an increased number of [emedicine.medscape.com] If hyperviscosity syndrome is present because of cryoglobulins, Raynaud phenomenon can be observed. [emedicine.medscape.com] Patients with type I cryoglobulins typically present with cutaneous manifestation related to hyperviscosity and/or thrombosis. [emedicine.medscape.com] IgE Myeloma Hyperviscosity syndrome in IgE myeloma. [bmj.com] Abstract A 60-year-old man with signs of anemia, thrombocytopenia and hyperviscosity was found to have multiple myeloma. [nejm.org] Related Articles Abstract A 60-year-old man with signs of anemia, thrombocytopenia and hyperviscosity was found to have multiple myeloma. [nejm.org] Erythrocytosis Hyperviscosity retinopathy can cause acute visual loss in cases of renal allograft recipients who develop PTE. [ncbi.nlm.nih.gov] In all patients, hydroxyurea improved symptoms of hyperviscosity. [ncbi.nlm.nih.gov] The patient's symptoms of hyperviscosity improved after phlebotomy, as his hemoglobin gradually decreased to 18.3 g/dL. [ncbi.nlm.nih.gov] Hyperviscosity Syndrome The course of a patient with rheumatoid hyperviscosity syndrome is described. [ncbi.nlm.nih.gov] In this review, we discuss the diagnosis and management of the hyperviscosity syndrome. [ncbi.nlm.nih.gov] Keywords: Hyperviscosity - hemorheology - cancer - thrombosis - hemostasis [doi.org] Livedo Reticularis […] physiologically akin to livedo reticularis (specifically livedo racemosa, Raynaud's phenomenon, and possibly ulceration) in that they arise from vasospasm with or without local hyperviscosity [doi.org] When factors, including cold, arteriolar disease and blood hyperviscosity, reduce blood flow rates in the superficial venous plexus, the cyanotic reticular pattern becomes [clinicaladvisor.com] Chilblain Lupus Erythematosus Type 1 The chilblain lesions are the result of microvascular injury secondary to exposure to cold and possibly hyperviscosity from immunological abnormalities, Elevated serum gammaglobulins [ncbi.nlm.nih.gov] Multiple erythematous plaques and reticulate telangiectasia on the face that produce large areas of disfigurement on confluence hyperviscosity from immunologic abnormalities [mussenhealth.us] Vasoconstriction produced by cold along with the hyperviscosity due to immunological abnormalities like hypergamm-aglobulinemia and rheumatoid factor are thought to lead to [ijdvl.com] Familial Polycythemia Burning sensation in fingers and toes With the hyperviscosity perfusion becomes poor causing ischemic pains[21]. [explainmedicine.com] Recording of symptoms of hyperviscosity syndrome and their severity Hyperviscosity syndrome symptoms: Headache Dizziness Altered mentation, sense of distance Visual disturbances [ncbi.nlm.nih.gov] Blood differential Blood smear CBC Hematocrit Hemoglobin Hemoglobin electrophoresis Hemolytic disease of the newborn Hyperviscosity - newborn Low white blood cell count and [icdlist.com] Cyanotic Congenital Heart Disease In all patients, hydroxyurea improved symptoms of hyperviscosity. [ncbi.nlm.nih.gov] In the current era, phlebotomy is rarely performed in these patients except in cases of hemoptysis or hyperviscosity symptoms. [ncbi.nlm.nih.gov] However, at highly increased hematocrit levels patients may experience hyperviscosity symptoms. [ncbi.nlm.nih.gov] Monoclonal Gammopathy […] protein of 30g/L, 10% plasma cells on bone marrow biopsy, without associated end organ dysfunction (hypercalcaemia, lytic skeletal lesions, renal dysfunction, anaemia and hyperviscosity [rcpa.edu.au] Greatly elevated serum levels of protein may result in a hyperviscosity syndrome. polyclonal gammopathy a hypergammaglobulinemia resulting from an increased production of [medical-dictionary.thefreedictionary.com] No patient demonstrated signs of hyperviscosity retinopathy. Fluorescein angiography showed no definite leakage in any involved eye. [iovs.arvojournals.org] Cryoglobulinemic Vasculitis It can temporarily remove the cryoglobulin (immune complexes) and reduce the hyperviscosity, which helps reduce morbidity. [dermatologyadvisor.com] Early plasma exchanges are mandatory in patients with hyperviscosity syndrome [9–11, 15, 52, 53]. [annalsofintensivecare.springeropen.com] However, patients with type I cryoglobulinemia are asymptomatic until the level of cryoglobulins is sufficiently high to cause hyperviscosity syndrome. [dovepress.com] Myeloma Kidney There are many factors in its aetiology, including reduced volume, hypercalcaemia, tubulointerstitial nephritis and more rarely, hyperviscosity syndrome. [dev.nefro.elsevier.es] Patients with hyperviscosity syndrome do benefit with plasmapheresis. [ncbi.nlm.nih.gov] Deposition of monoclonal IgM (larger size when compared to IgG) can result in hyperviscosity syndrome. [ncbi.nlm.nih.gov]
