Hyperviscosity: Causes & Reasons

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Possible Causes for Hyperviscosity

Waldenstrom Macroglobulinemia

Because hyperviscosity syndrome can be lethal, it must be recognized and managed early. [ncbi.nlm.nih.gov]

Symptomatic hyperviscosity did not impact overall survival (P = 0·12). [ncbi.nlm.nih.gov]

No manifestation of hyperviscosity syndrome was noted. Bone marrow biopsy disclosed the concurrent systemic involvement. [ncbi.nlm.nih.gov]

Polycythemia

Diagnosis of hyperviscosity syndrome is clinical. [msdmanuals.com]

The elevated blood cell mass results in hyperviscosity, which is associated with slow blood flow and an increased risk of thrombosis. [amboss.com]

Premature infants rarely develop hyperviscosity syndrome. [msdmanuals.com]

Multiple Myeloma

Hyperviscosity: Emergent plasmapheresis B. [clinicaladvisor.com]

Generalized malaise, fever, sluggish mentation, paresthesia, sensory loss, and infection can indicate hyperviscosity. [symptoma.com]

(Multiple Myeloma 와의 차이) Peripheral neuropathy, Organomegaly (hepatomegaly, splenomegaly, lymphadenopathy), Hyperviscosity syndrome (IgM 이 pentamer 이므로. [sondoctor.co.kr]

Heavy Chain Disease

Hyperviscosity. Nephrotic syndrome, cardiac failure, malabsorption. Peripheral neuropathies, carpal tunnel syndrome. [patient.info]

Treatment of symptomatic patients includes chemotherapy and supportive therapy aimed at the correction of anaemia and hyperviscosity. Chronic lymphocytic leukaemia. [patient.info]

Leukemia

Waldenström macroglobulinemia has a natural history and therapeutic options similar to CLL, with the exception of hyperviscosity syndrome associated with macroglobulinemia [cancer.gov]

Pyelonephritis

Xanthogranulomatous pyelonephritis (XGP) is a rare renal tumor that arises as a complication of chronic obstructive pyelonephritis of uncertain etiology. It is primarily an adult tumor seen occasionally in children associated with urinary tract obstruction due to congenital urological anomalies, nephrolithiasis, and[…] [ncbi.nlm.nih.gov]

Dehydration

Abstract This hospital-record review describes the clinical profile of hypernatremic dehydration in neonates. 49 neonates (3.4% of the total admitted newborns) developed hypernatremic dehydration between January 2014 and August 2015. The major presenting complaints were fever (34.6%), poor feeding (42.8%), loose[…] [ncbi.nlm.nih.gov]

Systemic Lupus Erythematosus

Systemic lupus erythematosus, abbreviated as SLE, is an autoimmune disease which primarily strikes women. Majority of the individuals with SLE experience joint pain, accompanied by swelling. Arthritis is also a common complaint. In addition to these, individuals also experience pain in chest, hair loss, and development of[…] [symptoma.com]

Cystic Fibrosis

Cystic fibrosis (mucoviscidosis) is an autosomal recessive genetic disorder of the exocrine glands. It is characterized by the production of abnormally viscous mucus by the affected glands. Cystic fibrosis is usually recognized in infancy or early childhood. The clinical manifestations of cystic fibrosis are typically[…] [symptoma.com]

Central Hypoventilation

Abstract Congenital central hypoventilation syndrome (CCHS) typically presents in the newborn period. A case series of five adults is presented, each heterozygous for a documented polyalanine expansion mutation in the PHOX2B gene and evidence of nocturnal alveolar hypoventilation. All cases had symptoms in[…] [ncbi.nlm.nih.gov]

Eisenmenger Syndrome

Erythrocytosis is present in most patients, but excessive phlebotomy may cause microcytosis and exacerbate the symptoms of hyperviscosity. [annals.org]

Chronic hypoxia caused by Eisenmenger syndrome may result in polycythemia with resultant hyperviscosity and bilateral central retinal vein occlusion. [ncbi.nlm.nih.gov]

The hemostatic changes associated with the syndrome may lead to thromboembolic events, cerebrovascular complications, or the hyperviscosity syndrome. [annals.org]

Central Retinal Vein Occlusion

We report in this article central retinal vein occlusion (CRVO) caused by hyperviscosity syndrome (HVS) in a young patient with mucosa-associated lymphoid tissue (MALT) lymphoma [ncbi.nlm.nih.gov]

When a patient less than 50 years of age experiences central retinal vein occlusion, other mechanisms, such as the hyperviscosity syndrome or the inflammatory condition (inflammation [ncbi.nlm.nih.gov]

It can cause a hyperviscosity syndrome secondary to the paraproteinaemia associated with the disease. [ncbi.nlm.nih.gov]

IgE Myeloma

Hyperviscosity syndrome in IgE myeloma. [bmj.com]

Related Articles Abstract A 60-year-old man with signs of anemia, thrombocytopenia and hyperviscosity was found to have multiple myeloma. [nejm.org]

Abstract A 60-year-old man with signs of anemia, thrombocytopenia and hyperviscosity was found to have multiple myeloma. [nejm.org]

Monoclonal Gammopathy

[…] protein of < 30g/L, < 10% plasma cells on bone marrow biopsy, without associated end organ dysfunction (hypercalcaemia, lytic skeletal lesions, renal dysfunction, anaemia and hyperviscosity [rcpa.edu.au]

Greatly elevated serum levels of protein may result in a hyperviscosity syndrome. polyclonal gammopathy a hypergammaglobulinemia resulting from an increased production of [medical-dictionary.thefreedictionary.com]

No patient demonstrated signs of hyperviscosity retinopathy. Fluorescein angiography showed no definite leakage in any involved eye. [iovs.arvojournals.org]

Leukostasis

Mortality is related to the underlying cause of the hyperviscosity syndrome. Stone MJ, Bogen SA. Evidence-based focused review of management of hyperviscosity syndrome. [emedicine.medscape.com]

If the underlying disease process is left untreated, the hyperviscosity will recur. [emedicine.medscape.com]

Vascular stasis and resultant hypoperfusion then lead to the clinical symptoms of hyperviscosity syndrome (HVS). [emedicine.medscape.com]

Polycythemia Neonatorum

The outlook is good for infants with mild hyperviscosity. Good results are also possible in infants who receive treatment for severe hyperviscosity. [medlineplus.gov]

Abstract In clinical practice, neonatal polycythemia has been used as a marker for neonatal hyperviscosity, implicated as a cause of long-term neurologic delay and damage [ncbi.nlm.nih.gov]

Neonatal polycythemia and hyperviscosity. Clin Perinatol. 1995 Sep. 22(3):693-710. [Medline]. Wirth FH, Goldberg KE, Lubchenco LO. Neonatal hyperviscosity: I. Incidence. [emedicine.medscape.com]

Idiopathic Recurrent and Disabling Cutaneous Herpes

Hyperviscosity syndrome Hyperviscosity syndrome is caused by a clinically significant increase in the viscosity of whole blood, which may result from an increased number of [emedicine.medscape.com]

If hyperviscosity syndrome is present because of cryoglobulins, Raynaud phenomenon can be observed. [emedicine.medscape.com]

Patients with type I cryoglobulins typically present with cutaneous manifestation related to hyperviscosity and/or thrombosis. [emedicine.medscape.com]

Stress Polycythemia

Since many aspects of hemorheology and hemodynamics are affected by disease or clinical states, these effects are discussed as are hyperviscosity syndromes, therapy for disturbed [books.google.com]

The elevated blood cell mass results in hyperviscosity, which is associated with slow blood flow and an increased risk of thrombosis.. [amboss.com]

[…] comparative studies; Hemodynamics, covering basic principles, microcirculation, in vivo effects, endothelium and methods; and Clinical Aspects of Hemorheology, covering hyperviscosity [books.google.com]

Secondary Polycythemia

I would do a phlebotomy if he has signs/symptoms suggestive of hyperviscosity, and his hemoglobin is above 18... Tue Jun 06, 05:05:00 PM Jennings said... [pulmonaryroundtable.blogspot.com]

[…] demonstrating a transient improvement in cardiovascular and cerebrovascular physiology, the benefit of phlebotomy is unclear with the possible exception in patients with hyperviscosity [ncbi.nlm.nih.gov]

Rarely seen under the age of 40 years The symptoms are due to: Hyperviscosity. Hypervolemia. Hypermetabolism. [labpedia.net]

Cryoglobulinemia

We describe the case of an HIV/HCV-infected patient with HCV-related chronic lymphoproliferative disease, mixed cryoglobulinemia and hyperviscosity syndrome. [ncbi.nlm.nih.gov]

Abstract: Hyperviscosity syndrome leads to vascular disturbances in different organs. [content.iospress.com]

Abstract Hyperviscosity syndrome leads to vascular disturbances in different organs. [ncbi.nlm.nih.gov]

Idiopathic Cryoglobulinemia

Cryoglobulinemia can also lead to small-vessel vasculitis, which can cause purpura; hyperviscosity and direct vascular trauma can contribute. [merckmanuals.com]

Quantification of cryocrit is useful in monitoring response to treatment, particularly in hyperviscosity syndromes. [clinicaladvisor.com]

Marked elevations of other immunoglobulins (especially IgA and IgG3) can also be associated with a hyperviscosity syndrome. Click here for Patient Education [merckmanuals.com]

Erythrocytosis

Hyperviscosity retinopathy can cause acute visual loss in cases of renal allograft recipients who develop PTE. [ncbi.nlm.nih.gov]

In all patients, hydroxyurea improved symptoms of hyperviscosity. [ncbi.nlm.nih.gov]

The patient's symptoms of hyperviscosity improved after phlebotomy, as his hemoglobin gradually decreased to 18.3 g/dL. [ncbi.nlm.nih.gov]

Polycythemia Vera

Hyperviscosity syndrome was defined as having 2 or more hyperviscosity symptoms. [ncbi.nlm.nih.gov]

Asymptomatic Patients may be asymptomatic and may present with vague symptoms of hyperviscosity. [medicaljoyworks.com]

The elevated blood cell mass results in hyperviscosity, which is associated with slow blood flow and an increased risk of thrombosis. [amboss.com]

Cryoglobulinemic Vasculitis

A hyperviscosity syndrome is the main clinical presentation in some patients with type I cryoglobulinemia. [cancernetwork.com]

Cryoglobulinemia with severe hyperviscosity syndrome requires plasmapheresis and chemotherapy of the underlying malignancy. [hopkinsvasculitis.org]

Quantification of cryocrit is useful in monitoring response to treatment, particularly in hyperviscosity syndromes. [clinicaladvisor.com]

Maternofetal Transfusion

Hyperviscosity in the neonate. J Pediatr 1973;82:1004. Hein HA and Lathrop SS. [uichildrens.org]

Because of the plethora and the likelihood of hypervolemia and hyperviscosity, the transfusion was continued until the equivalent of one blood volume of the infant (200 ml [journals.lww.com]

Infants with symptoms consistent with hyperviscosity should be tested immediately. [uichildrens.org]

Livedo Reticularis

When factors, including cold, arteriolar disease and blood hyperviscosity, reduce blood flow rates in the superficial venous plexus, the cyanotic reticular pattern becomes [clinicaladvisor.com]

Chilblain Lupus Erythematosus Type 1

The chilblain lesions are the result of microvascular injury secondary to exposure to cold and possibly hyperviscosity from immunological abnormalities, Elevated serum gammaglobulins [ncbi.nlm.nih.gov]

Multiple erythematous plaques and reticulate telangiectasia on the face that produce large areas of disfigurement on confluence hyperviscosity from immunologic abnormalities [mussenhealth.us]

Vasoconstriction produced by cold along with the hyperviscosity due to immunological abnormalities like hypergamm-aglobulinemia and rheumatoid factor are thought to lead to [ijdvl.com]

Disorders of Amino-Acid Transport

Pseudohyponatremia HYPERVISCOSITY SYNDROME ( Hyperviscosity syndrome is caused by high concentrations of paraproteins, typically with IgG >6,000 mg/dL or IgA >4,000 mg/dL [myelomapennstate.net]

Less common complications include venous thromboembolism and the hyperviscosity syndrome.  Renal impairment affects 20-40% of new cases. [slideshare.net]

[…] leading to intratubular calcium deposition  by increasing the toxicity of filtered light chains  Tubulointerstitial nephritis  Plasma cell infiltration of the kidneys  Hyperviscosity [slideplayer.com]

Familial Polycythemia

Burning sensation in fingers and toes With the hyperviscosity perfusion becomes poor causing ischemic pains[21]. [explainmedicine.com]

Recording of symptoms of hyperviscosity syndrome and their severity Hyperviscosity syndrome symptoms: Headache Dizziness Altered mentation, sense of distance Visual disturbances [ncbi.nlm.nih.gov]

Blood differential Blood smear CBC Hematocrit Hemoglobin Hemoglobin electrophoresis Hemolytic disease of the newborn Hyperviscosity - newborn Low white blood cell count and [icdlist.com]

Hyperviscosity Syndrome

Other conditions associated with blood hyperviscosity include shock, rheumatic disease, and diabetes. [symptoma.com]

Keywords: Hyperviscosity - hemorheology - cancer - thrombosis - hemostasis [doi.org]

The course of a patient with rheumatoid hyperviscosity syndrome is described. [ncbi.nlm.nih.gov]