Hypocalciuria: Causes & Reasons

Possible Causes for Hypocalciuria

The routine urine-test diagnosed hypocalciuria. Histopathological exams of the skin showed only chronic dermatitis. [scielo.br]

Gitelman Syndrome

CONCLUSION: Hypovolemia is not the sole cause of hypocalciuria in patients with GS. [ncbi.nlm.nih.gov]

Subsequently, urine finding revealed hypocalciuria and thus, a diagnosis of Gitelman's syndrome was made. [sjkdt.org]

Gitelman syndrome is a genetic condition that affects the renal tubules, leading to hypomagnesemia, hypokalemia and hypocalciuria, as well as acid-base imbalance (metabolic [symptoma.com]

Neonatal Severe Hyperparathyroidism

Diagnostic methods Biologically, children present with extremely high serum calcium and serum PTH levels and a relative hypocalciuria, but in some cases they present with [orpha.net]

Familial Hypocalciuric Hypercalcemia Type 2

Benign familial hypocalciuric hypercalcemia (FHH) is an autosomal dominant condition characterized by lifelong hypercalcemia, relative hypocalciuria, and inappropriately elevated [shifrinmd.com]

In FHH type 2, marked hypocalciuria is noted. FHH type 3 exhibits mild hypophosphatemia and elevated plasma PTH concentrations. [orpha.net]

It is caused by a loss-of-function mutation in the calcium-sensing receptor gene (CASR) leading to a general calcium-hyposensitivity, compensatory hypercalcaemia and hypocalciuria [shifrinmd.com]

Familial Hypocalciuric Hypercalcemia Type 3

In FHH type 2, marked hypocalciuria is noted. FHH type 3 exhibits mild hypophosphatemia and elevated plasma PTH concentrations. [orpha.net]

FHH also causes high levels of parathyroid hormone (PTH) and low levels of calcium in the urine (hypocalciuria). [rarediseases.info.nih.gov]

Diagnostic methods FHH is suspected when mild hypercalcemia is seen along with normal or slightly elevated PTH, relative hypocalciuria, and normal phosphate levels. [orpha.net]

Hereditary Neonatal Hyperparathyroidism

NSHPT is characterized by parathyroid hyperplasia, marked and symptomatic PTH-dependent hypercalcemia, relative hypocalciuria, and bone fragility. [iofbonehealth.org]

Diagnostic methods Biologically, children present with extremely high serum calcium and serum PTH levels and a relative hypocalciuria, but in some cases they present with [rarediseases.info.nih.gov]

FHH is characterized by hypercalcemia, hypocalciuria, hypermagnesemia, and normal to low levels of parathyroid hormone (PTH). [parathyroid.com]

Bartter Syndrome

In 1966, Hillel J Gitelman described the variant which presents at a later age than Bartter's syndrome and with hypocalciuria. [patient.info]

[…] renal tubular acidosis Hypokalemia Hypochloremia Metabolic alkalosis Normotension Elevated plasma renin level Hypokalemia Hypochloremia Metabolic alkalosis Hypomagnesemia Hypocalciuria [step1.medbullets.com]

Hypokalaemic alkalosis with hypocalciuria (Gitelman's syndrome). See also the separate articles on Hypokalaemia, Acid-base Balance and Renal Tubular Disease. [patient.info]

Autosomal Dominant Primary Hypomagnesemia with Hypocalciuria

Diagnostic methods Diagnosis relies on a hypomagnesemia, hypermagnesuria and hypocalciuria phenotype. [orpha.net]

In a large Dutch family with autosomal dominant renal hypomagnesemia, associated with hypocalciuria, we mapped the disease locus to a 5.6-cM region on chromosome 11q23. [ncbi.nlm.nih.gov]

renal; HOMG2; Isolated autosomal dominant hypomagnesemia; Isolated renal magnesium wasting; Renal hypomagnesemia type 2; Autosomal dominant primary hypomagnesemia with hypocalciuria [rarediseases.info.nih.gov]

Hypomagnesemia

Laboratory tests showed hypokalemia, metabolic alkalosis, hypocalciuria, and hypomagnesemia related to genetically proven GS. [ncbi.nlm.nih.gov]

All patients presented with hypomagnesemia with a high fractional excretion of Mg2+ and hypocalciuria. [ncbi.nlm.nih.gov]

IRH is distinguished from the autosomal-dominant form by the lack of hypocalciuria 24. [slideshare.net]

Liddle Syndrome

Bartter’s syndrome causes hypercalciuria while Gitelmann’s syndrome causes hypocalciuria. Gitelmann’s syndrome causes hpomagnesemia. [epomedicine.com]

The hallmark of hypocalciuria can be associated with ectopic calcification (chondrocalcinosis, sclerochoroidal calciﬁcation); urinary magnesium wasting can lead to hypomagnesaemia [academic.oup.com]

[…] helpful in type 2 Gitelman syndrome Much more common than Bartter syndrome Loss of function of NCCT (mutation in SCL12A3), hence resembles effect of thiazides Hypokalaemia, hypocalciuria [bigtomato.org]

Primary Hypomagnesemia with Secondary Hypocalcemia

IRH is distinguished from the autosomal-dominant form by the lack of hypocalciuria 24. [slideshare.net]

マグネシウム血症（familial hypomagnesemia with hypercalciuria and nephrocalcinosis）」「paracellin-1（paracellin-1）」「低カルシウム尿症を伴う常染色体優性低マグネシウム血症（autosomal dominant hypomagnesemia with hypocalciuria [natureasia.com]

In other cases, a basolateral protein (cyclin M2 protein) mutation has been described. [98] Isolated dominant hypomagnesemia with hypocalciuria IDH with hypocalciuria [31] [emedicine.medscape.com]

Metabolic Alkalosis

In contrast, hypomagnesemia and hypocalciuria are considered hallmarks of Gitelman's syndrome. [ncbi.nlm.nih.gov]

Gitelman's syndrome is an autosomal recessive salt-losing tubulopathy showing hypokalemic hypomagnesemic hypocalciuria with metabolic alkalosis and hyperreninemic hyperaldosteronism [ncbi.nlm.nih.gov]

In 1966, Hillel J Gitelman described the variant which presents at a later age than Bartter's syndrome and with hypocalciuria. [patient.info]

Hypermagnesemia

We postulate a proximal tubular defect in the absorption of NaCl leading to hypocalciuria, hypomagnesuria, and potassium wasting. [ncbi.nlm.nih.gov]

Keywords hypokalemia hypermagnesemia hypocalciuria distal delivery fractional distal solute reabsorption fractional proximal solute reabsorption To read this article in full [ajkd.org]

IDH is an autosomal dominant disorder associated with hypocalciuria and chrondrocalcinosis. [abdominalkey.com]

Crystal Arthropathy

The phosphocalcium balance was altered in nine (18%) cases: six patients had hypercalciuria two hyperphosphaturia, two hypocalciuria, one hypophosphaturia and one hypercalcemia [ncbi.nlm.nih.gov]

Hypercalcemia

Here, we describe a patient with acquired parathyroid hormone (PTH)-dependent hypercalcemia with associated hypocalciuria, found to have true lymphocytic parathyroiditis on [ncbi.nlm.nih.gov]

To evaluate the functional significance of a CaSR mutation, identified in a young infant who presented with hypercalcemia and hypocalciuria. [ncbi.nlm.nih.gov]

In FHH type 2, marked hypocalciuria is noted. FHH type 3 exhibits mild hypophosphatemia and elevated plasma PTH concentrations. [orpha.net]

Glutamyl Ribose-5-Phosphate Storage Disease

Porokeratosis GNT096 Genetic Posterior Fossa Malformation GNT122 Genetic Precocious Puberty GNT155 Genetic Precocious Puberty in Female GNT154 Genetic Primary Hypomagnesemia with Hypocalciuria [malacards.org]

Gullner Syndrome

"Enhanced passive Ca2+ reabsorption and reduced Mg2+ channel abundance explains thiazide-induced hypocalciuria and hypomagnesemia". [en.wikipedia.org]

− Gitelman syndrome Other names Primary renal tubular hypokalemic hypomagnesemia with hypocalciuria A model of transport mechanisms in the distal convoluted tubule. [en.wikipedia.org]

"The mechanism of hypocalciuria with NaCl cotransporter inhibition". Nature Reviews. Nephrology. 7 (11): 669–674. doi:10.1038/nrneph.2011.138. PMID 21947122. [en.wikipedia.org]

Familial Primary Hypomagnesemia with Normocalciuria and Normocalcemia

Diagnostic methods Diagnosis relies on a hypomagnesemia, hypermagnesuria and hypocalciuria phenotype. [orpha.net]

Familal Benign Hypercalcemia

Benign familial hypocalciuric hypercalcemia is an autosomal dominant condition characterized by lifelong hypercalcemia, relative hypocalciuria, and inappropriately elevated [uthealth.influuent.utsystem.edu]

Abnormalities in the CaSR here cause both hypercalcaemia and hypocalciuria. [ipfs.io]

We evaluated the role of parathyroid hormone in the relative hypocalciuria of FHH and characterized the renal transport of calcium in this disorder using three previously [scinapse.io]

Antenatal Bartter Syndrome

Inherited hypokalaemic alkalosis with low blood pressure can be divided into two groups-Gitelman's syndrome, featuring hypocalciuria, hypomagnesaemia and milder clinical manifestations [scienceopen.com]

Indeed, 6 patients (23%) were found to have hypocalciuria. Nozu also reported hypocalciuria in all patients with mutations in the CLCNKB gene. [journals.plos.org]

Seven patients (44%) presented hypercalciuria while one had hypocalciuria (6%). The remaining six (50%) had normal urine calcium levels. [journals.plos.org]

Bartter Syndrome Type 4

It is contradicted with the features of hypocalciuria in classic Gitelman syndrome. [bmcnephrol.biomedcentral.com]

This is a rare autosomal recessive disorder characterized by late onset hypokalemic metabolic alkalosis, hypocalciuria, and hypomagnesemia. [hindawi.com]

These patients usually have hypocalciuria and hypomagnesemia. Adult patients may have chondrocalcinosis from longstanding hypomagnesemia. II. [cancertherapyadvisor.com]

Bartter Syndrome Type 5

This is a rare autosomal recessive disorder characterized by late onset hypokalemic metabolic alkalosis, hypocalciuria, and hypomagnesemia. [hindawi.com]

They have hypomagnesemia and hypocalciuria. [indianjnephrol.org]

Hypochloremia, hypomagnesemia, failure to thrive in infancy, EAST syndrome Classic Bartter III (602522) CLCNKB/1p36 ClC-Kb chloride channel DCT Thiazide type Hypomagnesemia, hypocalciuria [hindawi.com]

Pointer Syndrome

[…] renin, high aldosterone, hypercalciuria, and an abnormal Na + -K + -2Cl − transporter in the thick ascending limb of the loop of Henle, whereas Gitelman syndrome causes hypocalciuria [en.wikipedia.org]

Bartter Syndrome Type 4A

Abstract We observed two patients who had hypokalemic metabolic alkalosis as well as hypomagnesemia and hypocalciuria with elevated serum renin levels. [ajkd.org]

Diagnosis of Gitelman syndrome is based on findings similar to Bartter syndrome, as well as on hypomagnesemia, or abnormally low serum concentrations of magnesium, and hypocalciuria [britannica.com]

EAST Syndrome

[…] basolateral membrane of the renal distal convoluted tubule, and its loss of function mimics renal features of Gitelman syndrome, with hypokalemic alkalosis, hypomagnesemia, and hypocalciuria [ncbi.nlm.nih.gov]

Individuals also demonstrated significant hypomagnesemia and hypocalciuria. [renalfellow.blogspot.com]

Biochemical investigations show a hypokalaemiac, hypochloraemic metabolic alkalosis with hypomagnesaemia and hypocalciuria, a constellation typical for impaired salt-transport [physoc.org]

Autosomal Recessive Proximal Renal Tubular Acidosis

Hypocalciuria and hypercalcaemia are accompanied by hypermagnesaemia with parathyroid hormone levels in the normal range. In general, treatment is not required. [patient.info]

The metabolic disorders that have been reported in association with AI include hypocalciuria, impaired urinary concentrating ability, and Bartter-like syndrome. [indianjnephrol.org]

[…] recessive Pathology Defect in SLC12A3; thiazide-sensitive sodium-chloride cotransporter Encoding in the distal convoluted tubule Presentation Hypokalaemic metabolic alkalosis, hypocalciuria [oxfordmedicaleducation.com]

Alkalosis

In 1966, Hillel J Gitelman described the variant which presents at a later age than Bartter's syndrome and with hypocalciuria. [patient.info]

Gitelman 증후군 1예 ABSTRACT Gitelman’s syndrome is an autosomal recessive disorder characterized by hypokalemic metabolic alkalosis, hypomagnesemia, and hypocalciuria that has [jsms.sch.ac.kr]

Biochemically, Gitelman syndrome is characterized by hypocalciuria and hypomagnesemia with renal magnesium wasting. [jci.org]

Hypokalemia

Key laboratory findings include hypokalemia, metabolic alkalosis, hypomagnesemia, and hypocalciuria (3–11). [clinchem.aaccjnls.org]

This article presents a case report of a patient with severe persistent hypokalemia, complementary laboratory tests indicated that's it was hypomagnesaemia and hypocalciuria [ncbi.nlm.nih.gov]

[…] tubulopathy caused by a defect of the thiazide-sensitive sodium chloride co-transporter at the distal tubule, leading to hypokalemia, metabolic alkalosis, hypomagnesemia, hypocalciuria [ncbi.nlm.nih.gov]

Idiopathic Hypercalcemia

R., even though hypovitaminosis D may cause hypocalciuria, raising the doubt of familial hypocalciuria hypercalcemia. [bmj.com]

There is PTH-dependent total and ionized hypercalcemia with hypocalciuria, mild hypermagnesemia, hypomagnesuria, and hypophosphatemia. [clinicaladvisor.com]

Concerning the third point, we were referring to hypocalciuria and by no means to hypercalcemia. [bmj.com]

Fibular Dimelia-Diplopodia Syndrome

[…] decompensation Oligoelements metabolism anomalies Organic acid metabolism anomalies Phosphocalcic metabolism anomalies Hypercalcemia Hypercalciuria Hyperphosphtemia Hypocalcemia Hypocalciuria [readbag.com]