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118 Possible Causes for hypocretin

  • Streptococcal Infection

    Narcolepsy with hypocretin/orexin deficiency, infections and autoimmunity of the brain.[] CSF hypocretin was 8.6 pg/nL (normal 110 pcg/nL). His polysomnography suggested sleep efficiency of 59% and restlessness.[] Narcolepsy with hypocretin deficiency occurs in approximately 1 out of 3,000 individuals. The incidence in children is not known.[]

  • ROHHAD Syndrome

    The diagnosis was confirmed by showing an absence of hypocretin-1 in the cerebrospinal fluid.[] The co-occurrence of ROHHAD with narcolepsy and the noted absence of hypocretin-1 in this patient’s cerebrospinal fluid led us to consider that genes specific to hypocretin[] This alternative could explain the variable timing of onset in the disease Hypocretin 1.[]

  • Alprazolam

    RATIONALE: The orexin-hypocretin system is important for translating peripheral metabolic signals and central neuronal inputs to a diverse range of behaviors, from feeding[]

  • Hypersomnia

    Her hypocretin, the hypothalamic neuropeptide controlling sleep-awake cycle, was significantly low in the cerebrospinal fluid (146 pg/mL) on admission.[] The level of hypocretin in cerebrospinal fluid was decreased in this patient.[] Aquaporin 4 (AQP4), a member of the AQP superfamily, is strongly expressed in the hypothalamus in which orexin (hypocretin)-containing neurons are primarily concentrated.[]

  • Sudden Infant Death Syndrome

    Recently, the hypocretin system, which promotes wakefulness, has been implicated in SIDS, since it has been reported that SIDS victims have fewer hypocretin neurons than infants[] Simple comparisons showed that CSF hypocretin levels in the 2-6 month age group were significantly lower than hypocretin levels in both the 0-2 month and 1-18 year group ([] […] p CONCLUSIONS: The CSF hypocretin levels were lower at the age of peak incidence for SIDS.[]

  • HIV Infection

    The case presented here raises the possibility that the HIV infection may play a role in the pathogenesis of NT1 serving as trigger for autoimmune-mediated destruction of hypocretin-secreting[]

  • Psychosis

    Positive HLA-QB1*06:02 and undetectable level of hypocretine in the cerebrospinal fluid were found. MRI and CT-scan were normal.[]

  • Kleine-Levin Syndrome

    However, partial hypocretin lesions without low CSF hypocretin-1 consequences cannot be definitely excluded in those disorders.[] A twofold decrease in hypocretin-1 was evidenced during the period of hypersomnia in comparison with the asymptomatic interval.[] Cerebrospinalfluid (CSF) hypocretin-1, histamine (HA), and its major metabolite tele-methylhistamine (t-MHA) levels were measured in two KLS patients in and out of episode[]

  • Neurosarcoidosis

    This is a novel case, demonstrating both hypocretin deficiency syndrome, as well as respiratory dysfunction from destruction of hypocretin neurons and extensive destruction[] Hypocretin/orexin, sleep and narcolepsy. Bioessays. 2001(5):397-408.[] Cross-Sectional Cohort Study. ( 27057889 ) Leonhard S.E....Brouwer M.C. 2016 46 1260: NEUROSARCOIDOSIS INDUCED PANHYPOPITUITARISM. ( 26570921 ) Sanghi V....Kapoor A. 2015 47 Hypocretin[]

  • Niemann-Pick Disease Type C

    All of the NPC cases with cataplexy demonstrated low levels of CSF hypocretin-1, confirming the association of reduced CSF hypocretin-1 levels with cataplexy in NPC.[] Hypocretin deficiency in niemann-pick type C with cataplexy.[] In our patient, the level of hypocretin-1 was determined as moderately low, 174 pg/ml (normal, 200 pg/ml).[]

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