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118 Possible Causes for hypocretin

  • Streptococcal Infection

    Narcolepsy with hypocretin/orexin deficiency, infections and autoimmunity of the brain.[aasmnet.org] CSF hypocretin was 8.6 pg/nL (normal 110 pcg/nL). His polysomnography suggested sleep efficiency of 59% and restlessness.[aasmnet.org] Narcolepsy with hypocretin deficiency occurs in approximately 1 out of 3,000 individuals. The incidence in children is not known.[aasmnet.org]

  • ROHHAD Syndrome

    The diagnosis was confirmed by showing an absence of hypocretin-1 in the cerebrospinal fluid.[ncbi.nlm.nih.gov] The co-occurrence of ROHHAD with narcolepsy and the noted absence of hypocretin-1 in this patient’s cerebrospinal fluid led us to consider that genes specific to hypocretin[pediatrics.aappublications.org] This alternative could explain the variable timing of onset in the disease Hypocretin 1.[flipper.diff.org]

  • Alprazolam

    RATIONALE: The orexin-hypocretin system is important for translating peripheral metabolic signals and central neuronal inputs to a diverse range of behaviors, from feeding[ncbi.nlm.nih.gov]

  • Hypersomnia

    Her hypocretin, the hypothalamic neuropeptide controlling sleep-awake cycle, was significantly low in the cerebrospinal fluid (146 pg/mL) on admission.[ncbi.nlm.nih.gov] The level of hypocretin in cerebrospinal fluid was decreased in this patient.[ncbi.nlm.nih.gov] Aquaporin 4 (AQP4), a member of the AQP superfamily, is strongly expressed in the hypothalamus in which orexin (hypocretin)-containing neurons are primarily concentrated.[ncbi.nlm.nih.gov]

  • Sudden Infant Death Syndrome

    Recently, the hypocretin system, which promotes wakefulness, has been implicated in SIDS, since it has been reported that SIDS victims have fewer hypocretin neurons than infants[ncbi.nlm.nih.gov] Simple comparisons showed that CSF hypocretin levels in the 2-6 month age group were significantly lower than hypocretin levels in both the 0-2 month and 1-18 year group ([ncbi.nlm.nih.gov] […] p CONCLUSIONS: The CSF hypocretin levels were lower at the age of peak incidence for SIDS.[ncbi.nlm.nih.gov]

  • HIV Infection

    The case presented here raises the possibility that the HIV infection may play a role in the pathogenesis of NT1 serving as trigger for autoimmune-mediated destruction of hypocretin-secreting[ncbi.nlm.nih.gov]

  • Psychosis

    Positive HLA-QB1*06:02 and undetectable level of hypocretine in the cerebrospinal fluid were found. MRI and CT-scan were normal.[ncbi.nlm.nih.gov]

  • Kleine-Levin Syndrome

    However, partial hypocretin lesions without low CSF hypocretin-1 consequences cannot be definitely excluded in those disorders.[ncbi.nlm.nih.gov] A twofold decrease in hypocretin-1 was evidenced during the period of hypersomnia in comparison with the asymptomatic interval.[ncbi.nlm.nih.gov] Cerebrospinalfluid (CSF) hypocretin-1, histamine (HA), and its major metabolite tele-methylhistamine (t-MHA) levels were measured in two KLS patients in and out of episode[ncbi.nlm.nih.gov]

  • Neurosarcoidosis

    This is a novel case, demonstrating both hypocretin deficiency syndrome, as well as respiratory dysfunction from destruction of hypocretin neurons and extensive destruction[ncbi.nlm.nih.gov] Hypocretin/orexin, sleep and narcolepsy. Bioessays. 2001(5):397-408.[priory.com] Cross-Sectional Cohort Study. ( 27057889 ) Leonhard S.E....Brouwer M.C. 2016 46 1260: NEUROSARCOIDOSIS INDUCED PANHYPOPITUITARISM. ( 26570921 ) Sanghi V....Kapoor A. 2015 47 Hypocretin[malacards.org]

  • Niemann-Pick Disease Type C

    All of the NPC cases with cataplexy demonstrated low levels of CSF hypocretin-1, confirming the association of reduced CSF hypocretin-1 levels with cataplexy in NPC.[ncbi.nlm.nih.gov] Hypocretin deficiency in niemann-pick type C with cataplexy.[ncbi.nlm.nih.gov] In our patient, the level of hypocretin-1 was determined as moderately low, 174 pg/ml (normal, 200 pg/ml).[ncbi.nlm.nih.gov]

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