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50 Possible Causes for hypocretin 1, receptor

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  • Streptococcal Infection

    Narcolepsy with hypocretin deficiency occurs in approximately 1 out of 3,000 individuals. The incidence in children is not known.[] Thus, we termed this antigen nephritis-associated plasmin receptor (NAPlr).[] Autoantibodies against glutamate receptor δ2 were detected in the cerebrospinal fluid, suggesting that the cerebellum might be injured by postinfectious immunologic reaction[]

  • Sudden Infant Death Syndrome

    RESULTS: Hypocretin levels were not significantly different between 1-5 years, 5-10 years, and 10-18 years.[] METHODS: We have evaluated the expression and distribution of the orexin receptors (orexin-1 and orexin-2 receptors) particularly in the rostral pons, where the KFN is located[] The neuropeptide substance P (SP) and its tachykinin neurokinin-1 receptor (NK1R) have been shown to play an integral role in the modulation of homeostatic function in the[]

  • Idiopathic Generalized Epilepsy

    All patients had unremarkable brain magnetic resonance imaging studies and cerebrospinal hypocretin-1 was assessed in two patients, revealing undetectable levels.[] Here, we evaluated the frequency of additional mutations in the GABA(A) receptor by direct sequencing of the complete open reading frame of the GABRA1 and GABRG2 genes from[] Mutations in the GABA A receptor γ subunit GABRG1 are also causative for this disorder.[]

  • Niemann-Pick Disease Type C

    All of the NPC cases with cataplexy demonstrated low levels of CSF hypocretin-1, confirming the association of reduced CSF hypocretin-1 levels with cataplexy in NPC.[] Such a response is remarkable since the underlying problem involves a membrane receptor for cholesterol.[] A1-receptor antagonist or adenosine degrading enzyme enhanced the fEPSP in both types of mice, but had a much weaker effect in the mutant mice, suggesting less tonic inhibition[]

  • Gamma Hydroxybutyrate

    Author information 1 Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, USA. [email protected] Abstract Hypocretin-1 is a hypothalamic neuropeptide[] We report the in vitro assessment of pharmacotoxicity for the high-affinity GHB receptor ligand, NCS-382, using neuronal stem cells derived from mice with a targeted deletion[] Gamma-hydroxybutyrate (GHB) is a GHB-/GABAB-receptor agonist. Reports from GHB abusers indicate euphoric, prosocial, and empathogenic effects of the drug.[]

  • Hypersomnia

    SETTING: ata were collected and CSF hypocretin-1 levels were measured using radioimmunoassay at the Sleep Disorders Center, Montpellier, France.[] Abstract The macrolide antibiotic clarithromycin can enhance central nervous system excitability, possibly by antagonism of GABA-A receptors.[] Although hypocretin receptor antagonists have been developed as sleep-inducing drugs, a high dose of suvorexant, a hypocretin receptor antagonist, inhibits gene expression[]

  • Narcolepsy

    CSF hypocretin-1 (n 6) and histamine/tele-methylhistamine (n 5) levels were assessed twice (median interval: 14.4 months) in four patients with definite and in two with atypical[] Study Objectives: Recently, antibodies to the hypocretin receptor 2 (HCRTR2-Abs) were reported in a high proportion of narcolepsy patients who developed the disease following[] Rico/8/1934 (PR8) strain, the backbone used in the construction of the reassortant strain X-179A that was used in Pandemrix vaccine, and reported on anti-hypocretin (HCRT) receptor[]

  • Kleine-Levin Syndrome

    However, partial hypocretin lesions without low CSF hypocretin-1 consequences cannot be definitely excluded in those disorders.[] We speculate that the recurrent hypersomnia and behaviour disturbance are related to epilepsy-like neuronal discharge from the thalamus due to dysfunction in GABAnergic receptors[] The GABA A receptor is the site where sleep-inducing drugs such as diazepam have their effects, and recent research suggests GABA A receptor antagonists may be useful in the[]

  • Idiopathic Hypersomnia

    All nine hypocretin-deficient patients were human leuckocyte antigen (HLA) DR2 positive, while two who had normal CSF hypocretin-1 levels were HLA DR2 negative.[] Emerging treatments for sleepiness include histamine H3 antagonists (eg, pitolisant) and possibly negative allosteric modulators of the gamma-aminobutyric acid-A receptor[] The efficacy of γ-aminobutyric acid-A receptor antagonists on objective EDS needs to be clarified.[]

  • Hypothalamic Dysfunction

    Cerebrospinalfluid (CSF) hypocretin-1, histamine (HA), and its major metabolite tele-methylhistamine (t-MHA) levels were measured in two KLS patients in and out of episode[] Serum LH, follicle-stimulating hormone (FSH), estradiol, and prolactin levels were measured at baseline and after administration of metoclopramide (a central D-2 dopamine receptor[] The importance of nutritional activation of the Toll-like receptor 4 and the inhibitor of NF-κB kinase subunit β/NK-κB and c-Jun amino-terminal kinase 1 inflammatory pathways[]

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