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15 Possible Causes for Hypodensity of the White Matter, Periventricular White Matter Gliosis

  • Binswanger Disease

    The radiological pattern of hypodensity of the white matter on CT scan (or an increased MRI signal), albeit much debated, seems to be more closely associated with hypertension[] Periventricular areas of white matter disruption and gliosis are seen on CT or MRI scan.[] Six of these showed severe white matter hypodensity, low grade atrophy, and dilated ventricles.[]

  • Sjogren-Larsson Syndrome

    Computed tomography scan revealed hypodense areas in the periventricular white matter. Skin biopsy demonstrated a lamellar ichthyosis.[] Magnetic resonance spectroscopy (MRS) may be useful to show high lipid densities in the white matter around the ventricles.[] A CT scan of the brain showed diffuse white matter attenuation involving the fronto-parietal lobes predominantly, evident as white matter hypodensity [Figure - 1] .[]

  • Progressive Multifocal Leukoencephalopathy

    Computed tomography of the brain frequently showed hypodense, nonenhancing white matter lesions.[] CT Asymmetric focal zones of low attenuation involving the periventricular and subcortical white matter.[] white matter lesions Magnetic resonance imaging (MRI) – more sensitive than CT Recommended initial scan if suspicion for PML Hyperintense subcortical white matter lesions[]

  • Sener Syndrome

    A, Initial CT scan through the basal ganglia shows a cyst ( white arrow ) and foci of calcifications ( black arrows ). Note also hypodensity of the white matter.[] The most frequent finding in the white matter is gliosis, mainly in the centrum semiovale and in the periventricular region.[] There were bilateral hyperintensities seen on T2-weighted images in the periventricular white matter and in the centrum semiovale.[]

  • Basal Ganglia Mass Lesion

    On imaging, these lesions appear as bilateral, asymmetrical, hypodense, patchy or confluent white matter lesions. 5 The lesions are nonenhancing without edema or mass effect[] Periventricular bands or 'rims' are thin linear lesions along the body of the lateral ventricles and are associated with subependymal gliosis.[] Distribution patterns of ischemic stroke and its mimics Regional gray and white matter Single vascular distribution stroke Ischemic infarctions in a single vascular distribution[]

  • Cerebral Amyloid Angiopathy

    […] of the white matter 25 MR: T2 hyperintensity of the white matter without involvement of subcortical U-fibers (cf. cerebral amyloid angiopathy related inflammation ) 7,25[] […] subcortical white matter.[] MRI revealed coalescent edematous white matter lesion, hyperintense on T2-weighted sequences, and multiple lobar microbleeds on T2*-weighted sequences.[]

  • Infantile Choroidocerebral Calcification Syndrome

    matter hypodensities Thick vermilion border Antenatal intracerebral hemorrhage Renal insufficiency Brachycephaly Telecanthus Carious teeth Arachnodactyly Hypogonadotrophic[] Variable deep and periventricular white matter gliosis/atrophy, ex-vacuo effect, apposition of sulci to ventricular surface.[] Cortical and white matter infarctions occur, and white matter involvement is significantly more common in the neonate than in the adult.[]

  • Posterior Cerebral Artery Thrombosis

    After 24 hours, a cerebral or cerebellar infarct is usually seen as a hypodense area by CT and abnormal signal intensity by MRI involving both the gray and white matter in[] matter; white matter (including periventricular) lesions showing punctate or confluent myelin rarefaction, gliosis, and axonal loss; and microbleeds .[] Lacunar infarcts seen deep within white matter and within the basal ganglia Hypodensity is the main finding and is due to Cytotoxic oedema initially Vasogenic oedema secondarily[]

  • Diffuse Cerebral Sclerosis of Schilder

    Noncontrast computed tomography scan brain done in emergency showed a large area of white matter hypodensity involving the left frontoparietal region.[] They have a predilection for the periventricular white matter, optic nerves, and spinal cord but spare no part of the CNS.[] Long-standing plaques are firm (sclerosis) because of gliosis. Plaques are randomly distributed.[]

  • Neuronal Ceroid Lipofuscinosis

    In case 13, CT scan showed hypodensity of the white matter mainly on temporo-occipital regions.[] […] confirm a loss of myelin and gliosis in periventricular white matter. 2 Consistent with these findings, our patients presented with enlarged sulci and ventricles in both[] […] in the periventricular white matter of 10 of 13 case subjects. 2 Increased signal intensity in the periventricular white matter on T2-weighted MR images in patients with[]

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