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164 Possible Causes for Hypoglycemia, Irinotecan, Peripheral Neuropathy

  • Pancreatic Adenocarcinoma

    There are different kinds, including: Insulinomas produce large amounts of the hormone insulin which can result in hypoglycemia ( low blood sugar).[pathology.jhu.edu] Options for front-line therapy include both infusional 5-fluorouracil, leucovorin, irinotecan, oxaliplatin (FOLFIRINOX) and the combination of gemcitabine plus nab-paclitaxel[ncbi.nlm.nih.gov] The main adverse effects are peripheral neuropathy, neutropenia, thrombocytopenia and fatigue.[nature.com]

  • Bronchogenic Carcinoma

    Cell Carcinoma o Appearances § Mediastinal adenopathy § Hilar mass § Small or invisible lung nodule o High metastatic potential o Rapid growth o May be associated with § Hypoglycemia[learningradiology.com] Etoposide, carboplatin, cislatin or irinotecan are recommended chemotherapeutic agents.[symptoma.com] neuropathy, acanthosis nigricans, and hypertrophic osteoarthropathy (Example: clubbing of fingers).[histopathology-india.net]

  • Malignant Neoplasm of Pancreas

    In addition, diffuse hyperplasia of beta cells, called nesidioblastosis, can cause hypoglycemia (abnormally low blood glucose levels) in infants.[britannica.com] If you’re in fairly good health you may receive FOLFIRINOX (5-FU/ leucovorin / oxaliplatin / irinotecan ).[webmd.com] […] may occur in either the central nervous system (CNS) or the peripheral nervous system (PNS).[en.wikipedia.org]

  • Paraneoplastic Syndrome

    […] and inexplicable hypoglycemia.[mattioli1885journals.com] He was then switched to cisplatin and irinotecan with good response and completed five cycles.[healio.com] Abstract POEMS (peripheral neuropathy, organomegaly, endocrinopathy, M protein, skin changes) syndrome is a rare multisystem paraneoplastic disorder.[ncbi.nlm.nih.gov]

  • Malignant Gastric Neoplasm

    A 90-year-old man presented with a 1-month history of progressive edema in both legs and several episodes of malaise and dizziness that were associated with hypoglycemia.[nejm.org] Irinotecan versus non‐irinotecan‐containing regimens for advanced gastric cancer Irinotecan versus non‐irinotecan‐containing regimens for advanced gastric cancer Patient or[doi.org] Side effects may include: tiredness nausea and vomiting nerve damage ( peripheral neuropathy ) hair loss diarrhoea anaemia (a lack of red blood cells) weight loss skin changes[nhs.uk]

  • Adenocarcinoma of the Ovary

    The 50% growth inhibitory concentrations (IC50) (nM) of various anticancer drugs were: cisplatin 10,000, paclitaxel 80, SN-38 (irinotecan metabolite) 460, and gemcitabine[ncbi.nlm.nih.gov] Insulinoma secretes excess INSULIN resulting in HYPOGLYCEMIA.[fpnotebook.com] Combination chemotherapy with irinotecan hydrochloride plus cisplatin has been reported to be effective for primary and recurrent or resistant CCC.[ncbi.nlm.nih.gov]

  • Drug-induced Hypoglycemia

    This case report comprises three cases of antipsychotic drug-induced hypoglycemia and hypothermia.[ncbi.nlm.nih.gov] Br Med J 4 : 599 – 600 13 , , , , , , , , , , 2007 A phase I and pharmacokinetic study of pemetrexed plus irinotecan in patients with advanced solid malignancies.[academic.oup.com] Gallanosa AG, Spyker DA, Curnow RT: Diabetes mellitus associated with autonomic and peripheral neuropathy after Vacor poisoning: a review.[globalrph.com]

  • Liver Failure

    The patient has the same mutation (c.547C T; p.Arg183Trp) as the first case and presented with neonatal lactic acidosis, hypoglycemia and severe episodes of liver failure.[ncbi.nlm.nih.gov] In a subgroup analysis (Oxaliplatin all, Oxaliplatin 6 cycles, Irinotecan all and Irinotecan 6 cycles), eFLRF was the only factor predictive for PHLF in all subgroups (all[ncbi.nlm.nih.gov] Herein, we describe two members of one family who presented with recurrent episodes of hepatic failure, cerebellar ataxia, peripheral neuropathy, and short stature.[ncbi.nlm.nih.gov]

  • Bronchial Adenocarcinoma

    Targeted therapy with drugs such as paclitaxel, carboplatin, irinotecan, and erlotinib has also shown results.[medical-dictionary.thefreedictionary.com] Cell Carcinoma o Appearances § Mediastinal adenopathy § Hilar mass § Small or invisible lung nodule o High metastatic potential o Rapid growth o May be associated with § Hypoglycemia[learningradiology.com] neuropathy, acanthosis nigricans, and hypertrophic osteoarthropathy (Example: clubbing of fingers).[histopathology-india.net]

  • Toxic Hepatitis

    Moreover, it appears retrospectively that both of them already experienced significant toxicity under irinotecan-based chemotherapy.[ncbi.nlm.nih.gov] The best example of this is perhexilene, an antianginal agent, which caused hepatotoxicity and peripheral neuropathy in people deficient in the CYP2D6 (debrisoquine hydroxylase[ncbi.nlm.nih.gov] […] in plasma concentrations of irinotecan when coadministered with Ketoconazole Tablets may increase the risk of potentially fatal adverse events.[drugs.com]

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