Hypoglycemia & No Retinopathy: Causes & Reasons

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Patient File

Sex unknown, Age unknown

Reported Symptoms

Hypoglycemia, No Retinopathy,

Negated

None

Unsure

None

Possible Causes

Diabetes Mellitus Type 2

Although both blood glucose control and sepsis can strongly affect the occurrence of severe hypoglycemia, few studies have examined the seasonal variation of severe hypoglycemia [ncbi.nlm.nih.gov]

OBJECTIVE: To assess factors associated with diabetic retinopathy (DR) screening uptake following a diagnosis of type 2 diabetes mellitus (type 2 diabetes) in Germany. [ncbi.nlm.nih.gov]

[…] of diabetic retinopathy (RP). [ncbi.nlm.nih.gov]

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Diabetes Mellitus Type 1

The main concern is hypoglycemia, which can cause sudden incapacitation. [ncbi.nlm.nih.gov]

Author information 1 Dept of Ophthalmology, Academic Medical Center, Amsterdam, The Netherlands. h.w.vandijk@amc.nl Abstract Diabetic retinopathy (DR) classically presents [ncbi.nlm.nih.gov]

In type 2 diabetes, PAD risk was associated with microalbuminuria (OR 2.1), macroalbuminuria (OR 3.3), background retinopathy (OR 1.9), proliferative retinopathy (OR 2.8), [ncbi.nlm.nih.gov]

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Diabetes Mellitus

The neonate did not experience hypoglycemia or other complications. Placental biopsy revealed normal findings. [ncbi.nlm.nih.gov]

[…] overall extent of retinopathy in both eyes. [doi.org]

Iatrogenic hypoglycemia, typically the result of the interplay of therapeutic hyperinsulinemia and compromised defenses resulting in hypoglycemia-associated autonomic failure [ncbi.nlm.nih.gov]

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Diabetic Autonomic Neuropathy

Until glucose counterregulation is more fully understood and methods for preventing hypoglycemia developed, patients with recurrent hypoglycemia unawareness or a history of [ncbi.nlm.nih.gov]

[…] management of a 49-year-old male with a 30-year history of Type 1 diabetes mellitus who had nephropathy (proteinuria 1.81 g/24 h, creatinine 136 micromol/l), proliferative retinopathy [ncbi.nlm.nih.gov]

RESULTS: Baseline PD in room light correlated with duration of diabetes mellitus (DM, p 0.049) and the presence of DM retinopathy (DMR, p 0.022). [ncbi.nlm.nih.gov]

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Long Chain Hydroxyacyl-CoA Dehydrogenase Deficiency

Treatment : It is important to avoid fasting to prevent hypoketotic hypoglycemia. [emilytam.com]

[…] hydroxyacyl-CoA dehydrogenase deficiency Symptoms and clinical features may include: 2 Clinical Features of Long-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency : Pigmentary retinopathy [familydiagnosis.com]

An association between retinopathy and DHA deficiency has been demonstrated. [emedicine.medscape.com]

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Mitochondrial Trifunctional Protein Deficiency

The onset is induced by fasting or illness and manifests as hypoketotic hypoglycemia. [symptoma.com]

Mitochondrial trifunctional protein deficiency, a recently identified disorder of fatty-acid oxidation, may show characteristic features such as peripheral neuropathy, pigmentary retinopathy [ncbi.nlm.nih.gov]

A pigmentary retinopathy may also develop over time. Very occasionally, adults presenting for the first time with a previously unrecognized disease are described. [rarediseases.info.nih.gov]

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Diabetic Hypoglycemia

A common medical definition of severe hypoglycemia is "hypoglycemia severe enough that the person needs assistance in dealing with it". [en.wikipedia.org]

The lights went out for me in early 2002 as a result of diabetic retinopathy—the death of my retinas. [visionaware.org]

This increased risk is associated with hypoglycemia and diabetes complications such as: retinopathy, cataracts and neuropathy. [ncbi.nlm.nih.gov]

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Insulin Resistance

[…] defense against developing hypoglycemia, favors severe hypoglycemia ( 41 ). [doi.org]

A 21-year old girl was diagnosed with diabetic retinopathy and cataract after 6 years of uncontrolled diabetes. [ncbi.nlm.nih.gov]

She developed severe proliferative diabetic retinopathy with neovascular glaucoma leading to blindness. [ncbi.nlm.nih.gov]

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Diabetes in Pregnancy

The most optimal inpatient strategies for the prevention of hyperglycemia and hypoglycemia proximate to delivery remain unclear and will depend upon factors such as maternal [ncbi.nlm.nih.gov]

Soubrane G, Canivet J, Coscas G (1985) Influence of pregnancy on the evolution of background retinopathy. [link.springer.com]

Hypoglycemia education important before and during pregnancy to prevent hypoglycemia Women with type 1 diabetes are at risk for ketoacidosis At lower blood glucose levels [ndei.org]

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Paraneoplastic Syndrome

[…] and inexplicable hypoglycemia. [mattioli1885journals.com]

Paraneoplastic retinopathy/optic neuropathy. Curr Treat Options Neurol. 2005;7(1):57-67. Chan JW. Paraneoplastic retinopathies and optic neuropathies. [eyewiki.aao.org]

Seen in febrosarcoma, haemangiofibropericytoma, hepatoma)  Diagnosis: fasting hypoglycemia  Plasma insulin/pro-insulin/peptide C during hypoglycemia  Treatment:  Anticancer [slideshare.net]

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Autonomic Neuropathy

The HRV parameter low frequency (LF) was significantly (P 0.029) reduced during hypoglycemia. [ncbi.nlm.nih.gov]

Diabetic retinopathy is the most significant risk factor predictive of the presence of CAN in patients with type 2 diabetes. [ncbi.nlm.nih.gov]

All patients were evaluated for detection of CAN (with standardised cardiovascular reflex tests), diabetes-related microvascular complications (polyneuropathy, retinopathy [ncbi.nlm.nih.gov]

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Hypoglycemia

On this page: What is hypoglycemia? What are the symptoms of hypoglycemia? What causes hypoglycemia in people with diabetes? How can hypoglycemia be prevented? [web.archive.org]

The lights went out for me in early 2002 as a result of diabetic retinopathy—the death of my retinas. [visionaware.org]

[…] the coronary arteries or of the blood vessels supplying the brain (risk of cardiac or cerebral complications of hypoglycaemia) as well as in patients with proliferative retinopathy [mymemory.translated.net]

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Maternal Diabetes Syndrome

Hypoglycemia that requires intervention may persist for as long as 1 week. [emedicine.medscape.com]

Class H: Diabetic cardiomyopathy Class R: Malignant retinopathy Class RF: Both nephropathy and retinopathy Pedersen's prognostic signs of pregnancy permit more accurate predictions [utmb.edu]

Diabetic retinopathy is treatable, especially if it is caught early. [nhs.uk]

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Hyperglycemia

Hypoglycemia: Hypoglycemia, or an insulin reaction, can happen if you are taking insulin or oral medications. Hypoglycemia means low blood glucose. [healthcentral.com]

Male sex increased the risk of developing retinopathy (OR 1.9, 95% CI 1.2-2.9). [ncbi.nlm.nih.gov]

More at PubMed, keywords: hypoglycemia OR hyperglycemia AND reptile [anapsid.org]

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Anemia

Serious adverse effects (eg, thrombocytopenia; necrotizing enterocolitis; hypoglycemia; hypocalcemia; shock, pulmonary edema, or both [caused by shifts in fluid balance]) [merckmanuals.com]

Despite its angiogenic effects,74 there are no consistent data that allow us to attribute a worsening of malignant tumors or diabetic retinopathy to EPO. [revespcardiol.org]

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Diabetic Neuropathy

The damage can also lead to hypoglycemia unawareness. [niddk.nih.gov]

PURPOSE: To explore any relationship between the markers of early retinal neuronal damage and peripheral diabetic neuropathy in subjects with no diabetic retinopathy (DR). [ncbi.nlm.nih.gov]

METHODS: Forty-one diabetic polyneuropathy (DPN) patients with no or mild retinopathy, 50 non-DPN diabetic patients with no or mild retinopathy, and 42 healthy controls without [ncbi.nlm.nih.gov]

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Malnutrition

Wasting can affect both children and adults. 7. the child at risk for:  Hypoglycemia  Hypothermia  Fluid overload/ heart failure  Infection A wasted child can be classified [de.slideshare.net]

This is particularly true of patients with albinism and retinopathy of prematurely. Eyeglasses, however, do not cure nystagmus. [eyeassociates.com]

High refractive error and retinopathy are common findings. The aetiology is thought to be a congenital disturbance of the fixational system. [patient.info]

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Panic Attacks

Risk factors Panic attacks are more common with: The use of stimulants like caffeine Hereditary factors Stressful situations Chemical imbalances as may occur with hypoglycemia [news-medical.net]

Retinitis pigmentosaSequelae of auto-immune diseaseToxic etiologiesChloroquine, thioridazineSequelae of infectious diseaseTuberculosis Syphilis Lyme diseaseD/D Pigmentary retinopathies [slideshare.net]

Hypoglycemia. A minor cardiac problem where one or more of the heart’s valves don’t close properly. Certain medications. [centerforanxietydisorders.com]

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Cerebral Malaria

Patients suffering from cerebral malaria may present with fever, altered consciousness, hypoglycemia, anemia, jaundice, convulsions and coma. [tandurust.com]

CONCLUSION: Malarial retinopathy is significantly associated with mortality in children with cerebral malaria. [ncbi.nlm.nih.gov]

Hypoglycemia, either due to severe malaria or due to drugs like quinine, may also present with similar manifestations. Hypoglycemia is more common in pregnancy. [malariasite.com]

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Insulin-Resistance Syndrome Type B

Few cases with hypoglycemia are reported. [link.springer.com]

Further chapters discuss diabetes in relation to albuminuria, obesity, Grave’s disease, proliferative diabetic retinopathy (PDR) and diabetic macular edema (PME). [books.google.de]

[…] focuses on outcomes and how they are tracked stresses early detection and therapy of end-organ complications discusses the effect of intensive diabetes management on reducing retinopathy [books.google.de]

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Mauriac's Syndrome

Continuous glucose monitoring showed hyperglycemia after meals and frequent hypoglycemia before meals. [koreamed.org]

We conclude that substantial elevation of serum IGF-1 may be another risk factor for the progression of mild diabetic retinopathy to the proliferative state. [ncbi.nlm.nih.gov]

Paradoxically, with improved control, retinopathy progressed rapidly. [journals.lww.com]

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Retinohepatoendocrinologic Syndrome

Rayner Lampert Rennert syndrome Reactive airway disease Reactive arthritis Reactive attachment disorder of early childhood Reactive attachment disorder of infancy Reactive hypoglycemia [fact-index.com]

[…] syndrome Re Rea-Reg * Reactive airway disease * Reactive arthritis * Reactive attachment disorder of early childhood * Reactive attachment disorder of infancy * Reactive hypoglycemia [en.academic.ru]

Lampert Rennert syndrome Re Rea-Reg Reactive airway disease Reactive arthritis Reactive attachment disorder of early childhood Reactive attachment disorder of infancy Reactive hypoglycemia [ssf.f15ijp.com]

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Pheochromocytoma-Islet Cell Tumor Syndrome

(IGF-II), causing hypoglycemia. [hindawi.com]

HP:0002666 6 hypercalcemia 31 HP:0003072 7 cerebral hemorrhage 31 HP:0001342 8 tachycardia 31 HP:0001649 9 elevated urinary norepinephrine 31 HP:0003345 10 hypertensive retinopathy [malacards.org]

[…] blood [ more ] 0003072 Hyperhidrosis Excessive sweating Increased sweating Profuse sweating Sweating Sweating profusely Sweating, increased [ more ] 0000975 Hypertensive retinopathy [rarediseases.info.nih.gov]

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Preeclampsia

[…] hyperammonemia throbocytopenia elevated BUN and Cr diagnosis lab findings most accurate: liver biopsy treatment delivery of fetus differentiate from HELLP also has renal failure, hypoglycemia [step2.medbullets.com]

Preeclampsia/eclampsia associated retinopathy is a term that defines the retinal pathologies seen in this hypertensive disorders of pregnancy. [eyewiki.aao.org]

In addition, rule out hypoglycemia as cause of seizure or result of seizure, and rule out hyperglycemia as a cause of mental status changes. [emedicine.com]

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Diabetic Angiopathy

Metabolic Diseases 2020 (Finland) Hyperglycemia and Hypoglycemia - Global Diabetes 2020 (Switzerland) Hypertension - Cardio Diabetes 2020 (Thailand) Hypertension and Stroke [diabetes.conferenceseries.com]

Severe consequences of diabetic angiopathy are Diabetic nephropathy Diabetic retinopathy Coronary heart disease Vascular dementia macroangiopathy microangiopathy generalized [flexikon.doccheck.com]

This diagnosis is delayed by 4 and 6 years, respectively, if retinopathy is staged exclusively by ophthalmoscopy. [onlinelibrary.wiley.com]

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Extreme Fetal Immaturity

Hypoglycemia. Hypoglycemia is low levels of blood glucose in the baby immediately after delivery. [stanfordchildrens.org]

Retinopathy of Prematurity (ROP) – This is a potentially blinding eye disorder. [americanpregnancy.org]

A routine eye exam is performed to screen for retinopathy of prematurity. He is found to have incomplete retinal vascularization to Zone 3 in both eyes. [hawaii.edu]

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Isolated optic nerve hypoplasia

(For more information on hypothyroidism, hypoglycemia and diabetes insipidus, please see the Related Disorders section of this report.) [rarediseases.org]

Anterior Chamber Brain and Optical Pathway Choroid Congenital Syndromes, Malformations and Abnomalities Conjunctiva Cornea Glaucomas, Ocular Hypertension Hypertensive Retinopathy [atlasophthalmology.com]

Systemic Features: Pituitary dysfunction and endocrinopathy may lead to life-threatening illness caused by adrenal crisis or hypoglycemia. [disorders.eyes.arizona.edu]

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Congestive Heart Failure

[…] rate of recurrent heart failure, whereas its benefit in reducing the risk of metabolic and nutritional disorders largely reflects a reduced incidence of hypokalemia and hypoglycemia [doi.org]

A telemedicine program for diabetic retinopathy in a Veterans Affairs Medical Center: the Joslin Vision Network Eye Health Care Model. [dx.doi.org]

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Donohue Syndrome

Glucose homeostasis is affected with hyperinsulinemia, fasting hypoglycemia, and postprandial hyperglycemia. [ncbi.nlm.nih.gov]

A 17-year-old girl with leprechaunism, under treatment with high doses of insulin, presented a florid diabetic retinopathy. [ncbi.nlm.nih.gov]

Microalbuminuria and retinopathy remain a risk in these patients with or without treatment, and the effect of rhIGF-1 on ovarian and cardiac changes is unknown. [flipper.diff.org]

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Diabetic Nephropathy

Without any prolonged exposure to excessively low external temperatures or hypothyroidism, pituitary insufficiency, adrenal insufficiency, sepsis, hypoglycemia, and diabetic [ncbi.nlm.nih.gov]

Here, we present three patients with edema, heavy proteinuria, chronic renal failure, in whom no past or present symptomatic glucose intolerance or diabetic retinopathy were [ncbi.nlm.nih.gov]

Patients with GFR levels 60 are more susceptible to hypoglycemia. [cancertherapyadvisor.com]

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