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352 Possible Causes for Hypokalemia, Proximal Muscle Weakness

  • Bartter's Disease

    Laboratory testing is significant for hypokalemia, hypochloremia, and metabolic alkalosis.[medbullets.com] Clinical findings Proximal muscle weakness, failure to thrive, short stature, convulsions, tetany, cramps, ileus, gout, mental retardation, enuresis, nocturia, polyuria, salt[medical-dictionary.thefreedictionary.com] Moderate hypokalemia can be nevertheless asymptomatic. Pathophysiology of hypokalemia helps to identify the course of treatment.[bblc.tv]

  • Cushing's Disease

    Tw o also demonstrated personality changes, hypertension and hypokalemia, the last of these being rarely reported in patients with Cushing's disease.[ncbi.nlm.nih.gov] The following signs and symptoms are common: Weight gain Skin changes Hirsutism Menstrual disorders Progressive proximal muscle weakness Infertility Impotence Moodiness, irritability[symptoma.com] Ectopic ACTH secretion was initially suspected on the basis of very high cortisoluria and ACTH concentrations, severe hypokalemia, a lung hypermetabolic lesion and a normal[ncbi.nlm.nih.gov]

  • Hypokalemic Periodic Paralysis

    Convincing evidence for a pro-arrhythmogenic factor other than hypokalemia is still lacking.[ncbi.nlm.nih.gov] She developed significant proximal muscle weakness within 16 hours after the initial dose. Her serum potassium was 1.6 mEq/L.[ncbi.nlm.nih.gov] Neurological examination revealed proximal muscle weakness and generalized hyporeflexia. There was no sensory abnormality and bowel or bladder involvement.[ispub.com]

  • Cushing Syndrome

    […] following features of CS: skin thinning, severe hypercortisolemia (24-hour urinary free cortisol 10 times the upper limit of normal), ectopic secretion of ACTH, and severe hypokalemia[ncbi.nlm.nih.gov] We report a case of a 74-year-old male patient who presented with severe hypokalemia, proximal muscle weakness, peripheral edema, metabolic alkalosis, and worsening hyperglycemia[ncbi.nlm.nih.gov] A 59-year-old man presented with nasal congestion and neck swelling and was noted to have hypokalemia, hypertension, and hyperglycemia.[ncbi.nlm.nih.gov]

  • Thyrotoxic Periodic Paralysis

    We report the rare case of a 43-year-old African-American man with thyrotoxic periodic paralysis associated with hypokalemia and hypophosphatemia.[ncbi.nlm.nih.gov] Thyrotoxic periodic paralysis is a rare endocrine disorder most prevalent among individuals of Asian descent that presents as proximal muscle weakness, hypokalemia, and signs[ncbi.nlm.nih.gov] A young Chinese American male presented with progressive proximal muscle weakness and inability to stand and walk.[ncbi.nlm.nih.gov]

  • Chronic Alcoholism

    The presence of thyrotoxicosis and hypokalemia does not always indicate a diagnosis of TPP.[ncbi.nlm.nih.gov] The principal clinical findings were weakness and tenderness of the proximal limbs and girdle muscle. He was unable to lift his head or any extremities from the bed.[ncbi.nlm.nih.gov] Recent reports have emphasized the occurrence of a myopathy in chronic alcoholism associated with hypokalemia.[ncbi.nlm.nih.gov]

  • Diabetes Mellitus

    Rarely, DKA patients may present with significant hypokalemia.[web.archive.org] Additionally, proximal diabetic neuropathy causes painful muscle atrophy and weakness. There is a link between cognitive deficit and diabetes.[en.wikipedia.org] To prevent hypokalemia, potassium replacement is initiated after serum levels fall below the upper level of normal for the particular laboratory (5.0–5.2 mEq/l).[web.archive.org]

  • Distal Renal Tubular Acidosis

    However, under certain conditions, PPIs may cause metabolic acidosis or hypokalemia, probably due to an inhibitory action on the proton pump that contributes to H( ) and K[ncbi.nlm.nih.gov] Hypokalemic paralysis, proximal muscle weakness and voiding difficulty were the common modes of presentation.[ncbi.nlm.nih.gov] The patient had proximal muscle weakness, rickets, nephrocalcinosis, hypokalemia, normal anion gap metabolic acidosis, and urine pH level of 6.80.[ncbi.nlm.nih.gov]

  • Periodic Paralysis

    The presentation is characterized by abrupt-onset hypokalemia and profound proximal muscular weakness, and commonly occurs after carbohydrate loading or exercise.[ncbi.nlm.nih.gov] She developed significant proximal muscle weakness within 16 hours after the initial dose. Her serum potassium was 1.6 mEq/L.[ncbi.nlm.nih.gov] Proximal muscle wasting, rather than hypertrophy, may be seen in patients with permanent weakness.[patient.info]

  • Renal Tubular Acidosis

    Subsequently, type 1 RTA due to Sjögren's syndrome was unveiled by sustained hypokalemia (3.3 to 3.4 mEq/L), persistent alkaline urine pH ( 6.0) despite metabolic acidosis[ncbi.nlm.nih.gov] Abstract A 19-year-old Indian man presented with a history of proximal muscle weakness, knock knees and gynaecomastia.[ncbi.nlm.nih.gov] He had proximal muscle weakness (graded 3/5) with hyporeflexia and muscle tenderness, but sensation was preserved.[mja.com.au]

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