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14 Possible Causes for Hypolobulated Megakaryocytes in the Bone Marrow

  • Myelodysplastic Syndrome due to 5q Deletion

    […] nuclei Large, agranular platelets , and megakaryocytes (in MDS-F) Bone marrow biopsy : hypercellular, dysplastic bone marrow with numerous cells of all three cell lines with[amboss.com] […] anemia ) Other possible findings Leukocytopenia and/or thrombocytopenia Nucleated RBCs , ringed sideroblasts , Howell-Jolly bodies , basophilic stippling Neutrophils with hypolobulated[amboss.com]

  • Alpha-Thalassemia-Myelodysplastic Syndrome

    hypolobulated megakaryocytes.[ncbi.nlm.nih.gov] A previously healthy 66-year-old man presented with hemoglobin of 9.3 g/dL, mean corpuscular volume 59 fL, and a bone marrow aspirate with increased erythroid precursors and[ingentaconnect.com] A previously healthy 66-year-old man presented with hemoglobin of 9.3 g/dL, mean corpuscular volume 59 fL, and a bone marrow aspirate with increased erythroid precursors and[ncbi.nlm.nih.gov]

  • Acute Panmyelosis with Myelofibrosis

    On admission, immature cells in the peripheral blood were increased and a bone marrow biopsy revealed myelofibrosis and a cluster of hypolobulated and/or nonlobulated megakaryocytes[annlabmed.org] In the photo note a myeloblast (circled), a trilobated dysplastic erythroblast (arrowed), and a small dysplastic megakaryocyte. ( b, c ) Bone marrow biopsy sections from patient[doi.org] Six years ago, he had an operation for spinal lipomatosis, and three years later, the cause of his thrombocytopenia was diagnosed as MDS after a bone marrow examination.[annlabmed.org]

  • Idiopathic Refractory Anemia

    […] nuclei Large, agranular platelets , and megakaryocytes (in MDS-F) Bone marrow biopsy : hypercellular, dysplastic bone marrow with numerous cells of all three cell lines with[amboss.com] […] anemia ) Other possible findings Leukocytopenia and/or thrombocytopenia Nucleated RBCs , ringed sideroblasts , Howell-Jolly bodies , basophilic stippling Neutrophils with hypolobulated[amboss.com]

  • 3p Deletion Syndrome

    […] as well as the presence of cytological abnormal megakaryocytes, especially hypolobulated, small megakaryocytes in the bone marrow.[nature.com] , 24 25 with the slight modification of Öst et al . 26 Dysmegakaryocytopoiesis was defined as an abnormal disturbed thrombocytopoiesis and/or reduction in the number of megakaryocytes[nature.com]

  • Refractory Anemia with Excess Blasts

    Marrow Normal to increased megakaryocytes with hypolobulated nuclei No Auer rods Note: In this proposed WHO system, the FAB MDS subgroup Refractory Anemia with Excess Blasts[caprockhematology.com] Marrow Unilineage dysplasia in granulocytes or megakaryocytes No Auer rods MDS with del(5q) "5q- syndrome" Peripheral Blood Anemia Platelets usually normal or increased Bone[caprockhematology.com] Monocytes Bone Marrow Unilineage or multilineage dysplasia 10-19 percent blasts Auer rods MDS-Unclassified (MDS-U) Peripheral Blood Cytopenias No or rare blasts No Auer rods Bone[caprockhematology.com]

  • Congenital Aplastic Anemia

    Otherwise, bone marrow space is largely filled up by fat and fibrotic stroma. Finally, genetic analyses are necessary to identify or confirm the causal mutation.[symptoma.com] ., hyponucleated small megakaryocytes, multinucleated red cells, hypolobulated or hypogranular myeloid cells may be recognized and are not to be considered malignant.[symptoma.com]

  • Acquired Idiopathic Sideroblastic Anemia

    Bone marrow examination revealed megakaryocyte proliferation, and the megakaryocytes displayed abnormal morphology.[imagebank.hematology.org] Other hypolobulated forms were present. Erythropoiesis was mildly increased and mild dysplastic changes were evident.[imagebank.hematology.org]

  • Autosomal Dominant Thrombocytopenia 5

    Bone marrow evaluation may reveal dysplasia and/or hypolobulated megakaryocytes.[clincancerres.aacrjournals.org] Bone marrow analysis had showed marked trilineage dysplasia with rare, hypolobulated megakaryocytes and strongly basophilic cytoplasm, leading to the diagnosis of MDS with[link.springer.com]

  • Urticarial Vasculitis

    The patient was negative for a JAK-2 mutation and subsequently had a bone marrow biopsy.[medicaljournals.se] This showed an increased number of megakaryocytes with focal clustering and large hyperlobulated and a few small hypolobulated forms.[medicaljournals.se]

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