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52 Possible Causes for Hypomyelination of Sural Nerve

  • Peripheral Neuropathy

    Nerve conduction studies demonstrated an asymmetric demyelinating-type peripheral neuropathy, and sural nerve biopsy documented reduced myelinated nerve fiber density with[ncbi.nlm.nih.gov] […] uniformly thin myelin sheaths, suggesting hypomyelination.[ncbi.nlm.nih.gov]

  • Hypomyelinating Leukodystrophy Type 5

    METHODS: We performed neurological examination, neurophysiological, neuroimaging, and neuropathological studies on sural nerve biopsy in 10 hypomyelination and congenital[ncbi.nlm.nih.gov] Sural nerve biopsy revealed hypomyelinated nerve fibers.[ncbi.nlm.nih.gov] More interesting, these findings appear to correlate with the results of neuropathologic studies of the sural nerves, which showed lack of myelin with reduced residual myelin[ajnr.org]

  • Déjerine-Sottas Disease

    The pathology of the sural nerve showed hypomyelinated fibers with absence of active demyelination and onion-bulb formations composed of two parallel layers of basement membrane[ncbi.nlm.nih.gov] A sural nerve biopsy specimen showed marked decreases in the numbers of both large and small myelinated fibers, abundant onion-bulb formation, and hypomyelination.[ncbi.nlm.nih.gov] Motor and sensory nerve conduction studies showed absent motor and sensory responses on electrical stimulation of the limb nerves.[ncbi.nlm.nih.gov]

  • Hypogonadotropic Hypogonadism

    The literature suggests that abnormal findings upon sural nerve biopsy may indicate peripheral hypomyelination, even in the absence of clinically and physiologically evident[ncbi.nlm.nih.gov] A sural nerve biopsy of this patient was normal, and this finding is further discussed.[ncbi.nlm.nih.gov] Brain magnetic resonance imaging showed hypomyelinated white matter, cerebellar atrophy, and a thin corpus callosum.[ncbi.nlm.nih.gov]

  • Congenital Cataract

    Electromyography and sural nerve histology were in accordance with a hypomyelinating neuropathy.[ncbi.nlm.nih.gov] Sural nerve biopsy revealed hypomyelinated nerve fibers.[ajnr.org] More interesting, these findings appear to correlate with the results of neuropathologic studies of the sural nerves, which showed lack of myelin with reduced residual myelin[ajnr.org]

  • Ataxia

    Sural nerve biopsy shows debris-lined myelin clefts, vacuolar disruption, and loss of normal myelin periodicity. Table 7.[emedicine.medscape.com] […] progressive ataxia Short stature Hypodontia Delayed puberty secondary to gonadal dysfunction Laboratory MRI shows white matter signal abnormalities consistent with central hypomyelination[emedicine.medscape.com]

  • Autosomal Recessive Congenital Cataract 5

    Sural nerve biopsy revealed hypomyelinated nerve fibers.[ajnr.org] More interesting, these findings appear to correlate with the results of neuropathologic studies of the sural nerves, which showed lack of myelin with reduced residual myelin[ajnr.org] Deep cerebellar white matter hypomyelination was found in 6 patients. Older patients had evidence of white matter bulk loss and gliosis.[ajnr.org]

  • Spinocerebellar Ataxia Type 6

    Sural nerve biopsy shows debris-lined myelin clefts, vacuolar disruption, and loss of normal myelin periodicity. Table 7.[emedicine.com] […] progressive ataxia Short stature Hypodontia Delayed puberty secondary to gonadal dysfunction Laboratory MRI shows white matter signal abnormalities consistent with central hypomyelination[emedicine.com]

  • Spinocerebellar Ataxia Type 13

    Sural nerve biopsy shows debris-lined myelin clefts, vacuolar disruption, and loss of normal myelin periodicity. Table 7.[emedicine.com] […] progressive ataxia Short stature Hypodontia Delayed puberty secondary to gonadal dysfunction Laboratory MRI shows white matter signal abnormalities consistent with central hypomyelination[emedicine.com]

  • Hereditary Motor and Sensory Neuropathy

    In this form, sural nerve biopsy shows a lack of large myelinated fibers, and motor nerve conduction velocities are only moderately slowed.[healio.com] A and B, LM and EM of the sural nerve specimen (Toluidin blue stain, semi-thin section) in a patient with the congenital hypomyelinating form of DSD (case 8).[ajnr.org] In other types of congenital hypomyelination neuropathy, clinical manifestations are variable.[healio.com]

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