Hypophosphatemia: Causes & Reasons

Possible Causes for Hypophosphatemia

Serum phosphorus concentration was 1.0 mg/dL, and severe hypophosphatemia was diagnosed. [oadoi.org]

The possible cause of her RM was attributed to severe hypophosphatemia (minimum serum phosphate, 0.8 mg/dL). [ncbi.nlm.nih.gov]

Abstract We report an unusual case of hypophosphatemia-related seizure in a child with diabetic ketoacidosis (DKA). [oadoi.org]

Osteomalacia

Phosphate wasting conditions such as hypophosphatemia or those associated with certain neoplasms can lead to osteomalacia. [journals.lww.com]

McKee, Osteopontin and the dento-osseous pathobiology of X-linked hypophosphatemia, Bone, 10.1016/j.bone.2016.11.019, 95, (151-161), (2017). [doi.org]

X-linked Hypophosphatemia Biological: burosumab Phase 3 Expanded Access : An investigational treatment associated with this study is available outside the clinical trial. [clinicaltrials.gov]

Proximal Renal Tubular Acidosis

Hypophosphatemia during the follow-up period was more frequent for FS than PRTA (69.2+/-26.1% vs. 7.0+/-25.8%, P [ncbi.nlm.nih.gov]

Fanconi's syndrome, with generalized proximal tubular dysfunction, causes glycosuria, aminoaciduria, hypophosphatemia, and rickets. [nmckk.jp]

Hypophosphatemia leads to bone demineralization because phosphate is responsible for calcium resorption in the bones. [ehealthwall.com]

X-Linked Hypophosphatemia

Causes - X-linked hypophosphatemia Prevention - X-linked hypophosphatemia Not supplied. [checkorphan.org]

X-linked hypophosphatemia (XLH) is the most common form of familial hypophosphatemia. [symptoma.com]

Abstract X-Linked hypophosphatemia (XLH) is the most common form of hereditary rickets caused by loss-of function mutations in the PHEX gene. [ncbi.nlm.nih.gov]

Familial Hypophosphatemia

Familial syndromes causing hypophosphatemia are considered to be rare in he general population. [symptoma.com]

(Also known as/Synonyms) Familial Hypophosphatemic Bone Disease Phosphate Diabetes X-Linked Hypophosphatemia (XLH) What is Familial Hypophosphatemia? [dovemed.com]

Familial hypophosphatemia is a term encompassing a group of genetic diseases that impair homeostatic pathways of phosphate in the body. [symptoma.com]

Rickets

Our findings indicate that cinacalcet is effective in normalizing the hyperparathyroidism and hypophosphatemia in these cases and in improving the bone pathology. [ncbi.nlm.nih.gov]

Blood tests reveal low levels of phosphate (hypophosphatemia) and inappropriately normal levels of vitamin D. [en.wikipedia.org]

glucosuria, aminoaciduria Vitamin D-resistant rickets Cystinosis Tyrosinosis Lowe syndrome Hypophosphatemia with nonendocrine tumors Oncogenic rickets - elaboration of humeral [learningradiology.com]

Hypokalemia

Laboratory tests revealed severe hypokalemia, hypophosphatemia, normal calcium levels associated with marked dehydration. [ncbi.nlm.nih.gov]

She presented with marked hypophosphatemia, hypokalemia, acute renal failure and acute respiratory failure. [ncbi.nlm.nih.gov]

BACKGROUND: Hypophosphatemia, hypomagnesemia, and hypokalemia occur in patients receiving parenteral nutrition (PN), mainly when the body's stores are depleted due to fasting [ncbi.nlm.nih.gov]

Renal Tubular Acidosis

[…] limited to bicarbonate or acid transport and may include defects in resorption of glucose, amino acids, and phosphate yielding concomitant glucosuria, Aminoaciduria, and hypophosphatemia [pathwaymedicine.org]

Laboratory investigations revealed chronic kidney disease with serum creatinine of 2.3 mg/dL and creatinine clearance of 40 mL/min, hypokalemia (3.2 mmol/L), hypophosphatemia [ncbi.nlm.nih.gov]

Laboratory testing is significant for hyperchloremic metabolic acidosis, hypophosphatemia, and hypokalemia. [step2.medbullets.com]

Hypomagnesemia

BACKGROUND: Hypophosphatemia, hypomagnesemia, and hypokalemia occur in patients receiving parenteral nutrition (PN), mainly when the body's stores are depleted due to fasting [ncbi.nlm.nih.gov]

Metabolic Derangements hypernatremia hyperkalemia hypophosphatemia .. hypercalcemia glucosuria extracellular fluid volume expansion (e.g. iatrogenic non-Mg-containing fluids [newmanveterinary.com]

[…] range: 1.7-2.4 mg/dL (= 1.4-2.0 mEq/L = 0.70 -1.00 mmol/L); - to convert mg/dL to mmol/L (SI units): multiply by 0.4114 Assoc. lytes abnormality: hypocalcemia, hypokalemia, hypophosphatemia [enotes.tripod.com]

Respiratory Alkalosis

However, the clinician should be aware of its existence in order to interpret the occurrence of hypophosphatemia. [alpfmedical.info]

[…] respiratory alkalosis is unique in that it CAN have full metabolic compensation (Only acid-base disorder that allows this) Clinical Associated changes HYPOcalcaemia, HYPOkalaemia, HYPOphosphatemia [lifeinthefastlane.com]

Minor hypophosphatemia and hypokalemia due to intracellular shifts and decreased ionized calcium (Ca++) due to an increase in protein binding may be present. [merckmanuals.com]

Parathyroid Adenoma

She developed hypercalcemia and hypophosphatemia at age 23. [ncbi.nlm.nih.gov]

Serum biochemistry showed hypercalcemia and hypophosphatemia. Serum parathormone level was high (512 pg/mL). [ncbi.nlm.nih.gov]

Corrected serum calcium was markedly elevated at 3.96 mmol/L with hypophosphatemia of 0.35 mmol/L. [ncbi.nlm.nih.gov]

Hyperparathyroidism

They were diagnosed with hypercalcemia, hypophosphatemia, high PTH concentrations, and osteoporosis. [doi.org]

It is associated with hypercalcemia and hypophosphatemia. [fpnotebook.com]

(EVIDENCE) 14B.3 Rickets and osteomalacia due to hypophosphatemia should be treated with neutral sodium phosphate salts. [web.archive.org]

Primary Hyperparathyroidism

It is associated with hypercalcemia and hypophosphatemia. [icd9data.com]

Metabolic profile revealed hypercalcemia with hypophosphatemia. Intact parathyroid hormone levels were elevated at 790 pg/ml. Vitamin D levels were deficient. [ncbi.nlm.nih.gov]

Hypercalcemia and hypophosphatemia are characteristic yet not specific for PHPT. [symptoma.com]

Hereditary Hypophosphatemic Rickets with Hypercalciuria

There are two types of hypophosphatemia: acute hypophosphatemia, which comes on quickly chronic hypophosphatemia, which develops over time Familial hypophosphatemia is a rare [healthline.com]

Mildly affected individuals may have hypophosphatemia without other signs and symptoms. [icdlist.com]

Individuals with mild disease may have hypophosphatemia without other signs and symptoms. [ivami.com]

Psychogenic Hyperventilation

Tetany occurs because respiratory alkalosis causes both hypophosphatemia and hypocalcemia. [merckmanuals.com]

Acquired Fanconi Syndrome

Diagnostic approach to hypophosphatemia and proximal renal tubular dysfunction is discussed. [ncbi.nlm.nih.gov]

Laboratory test results showed hypokalemia, hypocalcemia, hypophosphatemia, and hypouricemia. [ncbi.nlm.nih.gov]

The laboratory results showed the feature of proximal renal tubule dysfunction, particularly severe hypophosphatemia. [ncbi.nlm.nih.gov]

Renal Tubular Acidosis Type 1

Laboratory investigations revealed proximal tubular dysfunction (low molecular weight proteinuria, generalized hyperaminoaciduria, hypophosphatemia with hyperphosphaturia, [ncbi.nlm.nih.gov]

Fanconi's syndrome, with generalized proximal tubular dysfunction, causes glycosuria, aminoaciduria, hypophosphatemia, and rickets. [nmckk.jp]

→ vitamin D -resistant rickets / osteomalacia Epidemiology X-linked hypophosphatemic rickets (XLH) accounts for ∼ 80% of all familial causes of hypophosphatemia. [amboss.com]

Familial Periodic Paralysis

[…] in serum potassium caused by β-adrenergic bronchodilator treatment. 7 Clinical attacks also have been associated with diabetic ketoacidosis and combined hypokalemia and hypophosphatemia [mdedge.com]

Propranolol rapidly reverses paralysis, hypokalemia, and hypophosphatemia in thyrotoxic periodic paralysis. Am J Kidney Dis. 2001;37(3):620. [ Links ] 32. [scielo.org.mx]

Propranolol rapidly reverses paralysis, hypokalemia and hypophosphatemia in thyrotoxic periodic paralysis. [asean-endocrinejournal.org]

Vitamin D Deficiency

The current patient presented with distal RTA, hypocalcemia, and hypophosphatemia that were found to be secondary to both vitamin D deficiency and pSS. [ncbi.nlm.nih.gov]

In this paper, we report two cases showing the deleterious consequences of vitamin D deficiency in HD patients which is characterised by hypophosphatemia, hypocalcemia and [ncbi.nlm.nih.gov]

X-linked familial hypophosphatemia reduces vitamin D synthesis in the kidneys. [merckmanuals.com]

Hereditary Fructose Intolerance

At 9 years of age, a fructose tolerance test signified a positive result that induced hypoglycemia, transient hypophosphatemia, hyperuricaemia, elevation of serum magnesium [ncbi.nlm.nih.gov]

[…] yr-old man with a classical history of hereditary fructose intolerance (HFI) developed typical biochemical changes following an oral fructose load: fructosemia, hypoglycemia, hypophosphatemia [ncbi.nlm.nih.gov]

No hypoglycemia or hypertransaminasemia, hypophosphatemia, or hyperuricemia were recorded; urinary fructose was undetectable. [pediatrics.aappublications.org]

Glycogen Storage Disease Type 1

[…] revealing rickets, and from characteristic results from laboratory investigations showing proximal renal tubular dysfunction (massive glucosuria, proteinuria, phosphaturia, hypophosphatemia [orpha.net]

[…] rickets and failure to thrive due to proximal renal tubular dysfunction which is characterized by glucosuria, phosphaturia, generalized aminoaciduria, bicarbonate wasting and hypophosphatemia [journalofpediatriccriticalcare.com]

Proximal renal tubular dysfunction with glucosuria, phosphaturia, generalized aminoaciduria, bicarbonate wasting, and hypophosphatemia are characteristic findings(2,3). [indianpediatrics.net]

Hyperventilation

Tetany occurs because respiratory alkalosis causes both hypophosphatemia and hypocalcemia. [merckmanuals.com]

Malnutrition

Persistent hypophosphatemia unresponsive to supplements should raise clinical alertness. With complete resection of the neoplasm, the symptoms rapidly reverse. [ncbi.nlm.nih.gov]

This potentially fatal condition is associated with electrolyte disturbances including hypokalemia and hypophosphatemia In moderate to severe cases of malnutrition, enteral [emedicine.medscape.com]

Kwashiorkor

[…] without severe hypophosphatemia. [ncbi.nlm.nih.gov]

Increase in total-body sodium and decrease in total-body potassium Hypophosphatemia is associated with malnutrition and can result in high mortality, especially upon refeeding [unboundmedicine.com]

Findings in refeeding syndrome include acute imbalances in fluid and electrolyte status, including fluid overload or dehydration, hypophosphatemia, hypokalemia, hypomagnesia [cancertherapyadvisor.com]

Acute Alcohol Intoxication

The electrolyte derangements commonly associated with acute intoxication and chronic alcoholism and malnutrition (hypokalemia, hypomagnesemia, and hypophosphatemia) require [clinicaladvisor.com]

Acute ethanol intoxication can lead to metabolic disturbances such as lactic acidosis, hypophosphatemia, hypokalemia and hypomagnesemia. [emsworld.com]

[…] evaluate for evidence of acidosis, renal injury, hepatotoxicity, pancreatitis, coagulopathy, underlying chronic liver disease, electrolyte imbalances (e.g., hypomagnesemia, hypophosphatemia [clinicaladvisor.com]

Cadmium Poisoning

The proximal renal tubular dysfunction creates low phosphate levels in the blood (hypophosphatemia), causing muscle weakness and sometimes coma. [en.wikipedia.org]

[…] ingestion)  Bronchitis (inhalation)  Interstitial pneumonitis (inhalation)  Pulmonary edema (inhalation) MEDICAL CONDITIONS  Osteoporosis  Osteomalacia  Hyperuricemia  Hypophosphatemia [slideshare.net]

[…] poisoning (ingestion) Bronchitis (inhalation) Interstitial pneumonitis (inhalation) Pulmonary edema (inhalation)MEDICAL CONDITIONS Osteoporosis Osteomalacia Hyperuricemia Hypophosphatemia [slideshare.net]

Autosomal Recessive Hypophosphatemic Rickets Type 2

“Treatment of severe hypophosphatemia”. Ann Intern Med. vol. 89. 1978. pp. 941-4. (An excellent overview of hypophosphatemia and its treatment.) [endocrinologyadvisor.com]

"Burosumab Therapy in Children with X-Linked Hypophosphatemia". [en.wikipedia.org]

There are two types of hypophosphatemia: acute hypophosphatemia, which comes on quickly chronic hypophosphatemia, which develops over time Familial hypophosphatemia is a rare [healthline.com]

Liver Failure

Also, severe electrolye abnormalities (hyponatremia, hypophosphatemia, hypokalemia, hypomagnesemia, also metabolic acidosis). Patients often need CVVH. 5. [errolozdalga.com]

[…] physiologic oxygen concentration과 mild hypocapnia를 유지 9. renal dysfunction의 경우, 조기에 continuous renal replacement therapy를 한다 --> electrolyte abnormalities (예, hypokalemia, hypophosphatemia [sondoctor.co.kr]

Hypophosphatemia – • Serum phosphorus should be monitored frequently, as hypophosphatemia can be profound. • the mechanism is unknown, • hypophosphatemia is presumed to result [slideshare.net]

Legionnaires' Disease

(specific to Legionnaires' disease excluding other causes of hypophosphatemia) Microscopic hematuria Proteinuria (40%) Use of antibiotics and some of the newer macrolides [symptoma.com]

Laboratory data may include an abnormal liver function test, low phosphorus in the blood (hypophosphatemia), blood in the urine (hematuria), and low blood sodium (hyponatremia [rarediseases.org]

[…] following: Elevated liver enzyme levels Highly elevated erythrocyte sedimentation rate (ESR) Highly elevated ferritin levels Increased C-reactive protein (CRP) levels (>30 mg/L) Hypophosphatemia [symptoma.com]

Aluminum-Based Antacid

*Constipation; hypophosphatemia (acute tx for hyperphosphatemia; renal osteodystrophy, encephalopathy Magnesium Side effects? [studystack.com]

It is recommended that a doctor with a sulto long-term use or in patients at risk or hypophosphatemia. [cosmofarm.it]

Antacids that contain aluminum hydroxide may cause constipation, aluminum-intoxication, osteomalacia, and hypophosphatemia. [rxlist.com]