Hypopigmented Macule: Causes & Reasons

Possible Causes for Hypopigmented Macule

Hypopigmented macules are the earliest sign. [ncbi.nlm.nih.gov]

The mother and other family members with the mutation were asymptomatic except for the presence of hypopigmented macules. [ncbi.nlm.nih.gov]

The earliest finding, and the most common in the skin, consists of hypopigmented macules (ash leaf). [omicsonline.org]

Tinea Versicolor

Presented in this report is a 34-year-old man with an interesting case of folliculocentric tinea versicolor manifesting as perifollicular hypopigmented macules on the lower [ncbi.nlm.nih.gov]

Hypopigmented macules persisted for several months in most patients. [ncbi.nlm.nih.gov]

It manifests clinically as asymptomatic hypopigmented macules, hyperpigmented macules, or a combination of the two. [ncbi.nlm.nih.gov]

Pityriasis Alba

2-5 mm hypopigmented macules Comments: This infant with a history of seborrheic dermatitis developed hypopigmented macules on his forehead and eye brows. [web.archive.org]

Abstract Pityriasis alba (PA) is a relatively common skin disorder usually seen in children and young adults characterized by the presence of superficial hypopigmented macules [ncbi.nlm.nih.gov]

Dermatological examination revealed hypopigmented macules in 193 (96.5%) cases and hypopigmented macules with central hyperpigmentation in 7 cases. [ijdvl.com]

Dyskeratosis Congenita

The hypopigmented macules showed no discernible erythema upon rubbing or the local application of heat. [ncbi.nlm.nih.gov]

Herein, we report a 31-year-old male with history of recurrent febrile episodes who was found to have reticulate skin pigmentation interspersed with hypopigmented macules [ncbi.nlm.nih.gov]

General examination showed hypopigmented macules with reticular hyperpigmentation involving the trunk, upper, and lower limbs [Figure 1] c and d]. [meajo.org]

Vitiligo

macules on the trunk Idiopathic guttate hypomelanosis: multiple hypopigmented macules on the sun-exposed areas; common in elderly individuals Nevus depigmentosus: a well-defined [amboss.com]

Vitiligo is signified by acquired white or hypopigmented macules or patches. [symptoma.com]

Hypopigmented macules: Tinea versicolor – Potassium hydroxie (KOH) positive. Mild scale noted; often seen in the shoulders, upper trunk. [visualdx.com]

Cutaneous T-Cell Lymphoma

Clinical Variants of MFHypopigmented MF Hypopigmented MF is an uncommon clinical variant of MF characterized by hypopigmented macules and papules without atrophy (Fig. 2A) [actasdermo.org]

Early CTCL often lacks the histologic criteria necessary for a definitive diagnosis. 5 PVA presents as atrophic, hypopigmented and hyperpigmented macules and patches with [aafp.org]

In dark-skinned individuals, the patches may appear as hypopigmented or hyperpigmented areas. As patches become more infiltrative, they evolve into palpable plaques. [patient.info]

T-Cell Lymphoma

Early CTCL often lacks the histologic criteria necessary for a definitive diagnosis. 5 PVA presents as atrophic, hypopigmented and hyperpigmented macules and patches with [aafp.org]

In dark-skinned individuals, the patches may appear as hypopigmented or hyperpigmented areas. As patches become more infiltrative, they evolve into palpable plaques. [patient.info]

The skin disease generally progresses from: Patch phase (up to 15 cm across) : flat, erythematous pink-brown macules that may have a fine scale, may be single or multiple [patient.info]

Epidermodysplasia Verruciformis

A 3-year-old African American girl taking sirolimus and tacrolimus for a small bowel transplantation presented with hypopigmented macules and papules throughout her trunk. [ncbi.nlm.nih.gov]

Figure 1: (a) Multiple hypopigmented macules and papules coalescing to form patches over the forehead. [ijpd.in]

Dermatological examination demonstrated thin, scaly, slightly verrucous hypopigmented macules and papules, isolated or presenting with a linear aspect (Köbner phenomenon) [ncbi.nlm.nih.gov]

Legius Syndrome

Other less common manifestations include short stature, macrocephaly, Noonan-like facies, pectus excavatum/carinatum, lipomas, hypopigmented macules, vascular lesions, learning [orpha.net]

The number of café-au-lait macules tends to increase with age during childhood. [orpha.net]

Pityriasis Lichenoides

Patients may have guttate, hypopigmented macules with scale in addition to papules. [escholarship.org]

Hypopigmented nonscaly macules and small patches in a patient with a darker skin type. (Courtesy of Dr. Leslie Castelo-Soccio.) [basicmedicalkey.com]

The diagnosis of PLC should be included in the differential diagnosis in dark-skinned patients who present with widespread hypopigmented macules and patches. [ncbi.nlm.nih.gov]

Aicardi's Syndrome

Article type: Research Article Authors: Gowda, Vykuntaraju K.N. ; | Reddy, Bharath | Madivala, Bhaskar V. | Ramaswamy, Premalatha | Gowda, Sarala H.S. Affiliations: Department of Pediatric Neurology, Indira Gandhi Institute of Child Health, Bangalore, Karnataka, India | Indira Gandhi Institute of Child Health, Department[…] [content.iospress.com]

Subungual Fibroma

Hypopigmented macules. [slideshare.net]

A female toddler with known TSC presented with multiple skin lesions characteristic of TSC; these included 5 facial collagenomas, more than 20 hypopigmented macules and patches [jamanetwork.com]

One study has also reported improvement in hypopigmented macules. [dermnetnz.org]

Acromelanosis

We describe an otherwise healthy 7-year-old boy who developed confetti-like hypopigmented macules on the dorsal aspects of the hands and feet, spreading to the palms and soles [ncbi.nlm.nih.gov]

Type your tag names separated by a space and hit enter Abstract We describe an otherwise healthy 7-year-old boy who developed confetti-like hypopigmented macules on the dorsal [unboundmedicine.com]

Examination revealed multiple hyperpigmented irregular macules interspersed with tiny 0.3x0.3 cm hypopigmented round macules on the palms, flexor and extensor aspects of fingers [ijdvl.com]

Extensive Burns

Abstract To investigate circulating cytokine responsiveness in major burns in association with the systemic stress response system, we tested hypothalamic-pituitary-adrenal (HPA) axis markers in extensive burn cases treated in the Department of Plastic and Reconstructive Surgery at Nagasaki University. The HPA[…] [ncbi.nlm.nih.gov]

Piebaldism

A further hypopigmented macule was evident on the forehead and it was associated with leukotrichia on the vertex, upper eyelids and eyebrows. [academic.oup.com]

Common characteristics include a congenital white forelock, scattered normal pigmented and hypopigmented macules and a triangular shaped depigmented patch on the forehead. [dbpedia.org]

Well-demarcated hypopigmented macules with areas of hyperpigmentation on trunk, upper extremities, forehead and eyelids with leukotrichia. [academic.oup.com]

Dyschromatosis Universalis Hereditaria

We have presented a case series comprised of six members of a family who had numerous hyperpigmented and hypopigmented macules distributed all over the body. [ncbi.nlm.nih.gov]

The main feature of DUH is a mixture of hypopigmented and hyperpigmented macules, distributed symmetrically. [docksci.com]

Dyschromatosis universalis hereditaria is an autosomal dominant genodermatosis, characterized by small hyperpigmented and hypopigmented macules, uniformly distributed over [ncbi.nlm.nih.gov]

Dyschromatosis Universalis Hereditaria Type 1

Wu and Lin reported that hyperpigmented macule had lesser degree of acanthosis compared to the hypopigmented macule [ 3 ]. [omicsonline.org]

Symmetric hypopigmented patch with spotty hyperpigmentary macules were seen on the palms [Figure 4]. Soles were not affected. [idoj.in]

Physical examination revealed numerous asymptomatic, generalized, 0.5- 5 cm hyperpigmented macules interspersed with spotty hypopigmented macules. [dermatology.cdlib.org]

Dyschromatosis Symmetrica Hereditaria

Her parents noted that hyperpigmented and hypopigmented macules on the dorsal aspects of the hands developed at 5 months of age. [mdedge.com]

Figure 2 Reticulate hyperpigmented and hypopigmented macules on neck and upper chest. Figure 3 Reticulate hyperpigmented and hypopigmented macules on dorsa of hands. [dovepress.com]

The characteristic appearance of DSH is a mixture of hyperpigmented and hypopigmented macules of various sizes on the dorsal aspects of the hands and feet. [mdedge.com]

Zosteriform Lentiginosis

Presented by Henry Foong, Ipoh, Malaysia A healthy 16 year old girl complains of asymptomatic 1-2 mm in diameter hypopigmented macules on both shins since birth. [vgrd.blogspot.com]

The hypopigmented macules showed a decrease in pigmentation of the basal layer. [plasticsurgerykey.com]

[…] and cardiac abnormalities Piebaldism CALM, congenital depigmented patches Rarely mental retardation ananglionic megacolon, Hirschsprung diseasex Westerhof syndrome CALM, hypopigmented [accesspediatrics.mhmedical.com]

Borderline Leprosy

Hypopigmented macule and plaques all over the body D. Glove and stocking anesthesia 9. [quizlet.com]

[…] center and raised erythematous border Lepromatous leprosy has macules, papules and plaques, but firm nodules may also be seen in the face Borderline leprosy has hypopigmented [pathologyoutlines.com]

Histamine Test Tuberculoid leprosy causes hypopigmented macules: the response of the skin to histamine will be delayed, diminished, or even absent. [isradiology.org]

Incontinentia Pigmenti Achromians

Farlex Partner Medical Dictionary © Farlex 2012 Ito, Minor, Japanese dermatologist, 1884-1982. hypomelanosis of Ito - inherited hypopigmented macules variably associated with [medical-dictionary.thefreedictionary.com]

Ito, Minor, Japanese dermatologist, 1884-1982. hypomelanosis of Ito - inherited hypopigmented macules variably associated with epidermal nevi, alopecia, and ocular, skeletal [medical-dictionary.thefreedictionary.com]

macules in whorls, streaks, and patches in a "marble-cake" pattern, variably associated with epidermal nevi, alopecia, and ocular, skeletal, and neural abnormalities. [medical-dictionary.thefreedictionary.com]

Bloch Sulzberger Syndrome

At 3 years old, there were already hypopigmented-scarring macules. Vesicles always result from fever and/or when infection occurs. [peertechz.com]

appear as hypopigmented linear macules/patches. [dailyrounds.org]

[…] linear macules on the trunk and limbs usually observed in adulthood. [radiopaedia.org]

Chronic Lichenoid Pityriasis

Erythematous scaly papules mixed with hyper or hypopigmented macules over trunk, limbs are seen. removal of scale reveals shiny brown surface underneath. [en.wikipedia.org]

macules. [getpdffrommia.me]

macules (Rev Chil Pediatr 2015;86:121) 37 year old woman developed papular eruption after first dose of MMR vaccine (J Dtsch Dermatol Ges 2020;18:758) 38 year old man with [pathologyoutlines.com]

Cutaneous Amyloidosis

Amyloid deposits were shown histopathologically in both hyperpigmented and hypopigmented macules. [ncbi.nlm.nih.gov]

Clinically, it presents with diffuse brownish pigmentation with hypopigmented macules and many brownish scattered lichenoid papules with normal developmental milestones. [ [e-ijd.org]

A and B, Generalised mottled hyper- and hypopigmented macules were distributed over the entire body (patient 1b). [ojrd.biomedcentral.com]

Absent Thumb - Short Stature - Immunodeficiency Syndrome

The presentations vary from the reticular or net like pattern to the" freckle like" hyper and hypopigmented macules that are usually restricted to the true genetic "reticulate [ijdvl.com]

macules, shagreen patch, facial angioma/adeoma sebaceum, ungual fibromas, seizures/infantile spasms, cardiac rhabdomyomas, renal tumors Term Definition nuchal webbing, pedal [flashcardmachine.com]

macules) facial angiofibromas Cardiac rhabdomyomas Renal angioleiomyomas retard seizures Childhood Recurrent gross hematuria & proteinuria Sensorineural deafness Family history [quizlet.com]

Multibacillary Leprosy

Few numbers of hypopigmented macules (cutaneous lesions) may occur. Loss of sensation is rare. [web.stanford.edu]

The initial lesion, "indeterminate leprosy", is a symptomless, ill-defined, slightly hypopigmented macule, commonly on the face or trunk. [isradiology.org]

Idiopathic Recurrent and Disabling Cutaneous Herpes

Patients with Fanconi anemia can exhibit hypopigmented macules. [emedicine.medscape.com]

Melhem-Fahl Syndrome

[…] hereditary congenital hypopigmented and hyperpigmented Madokoro Ohdo Sonoda syndrome Magnesium defect in renal tubular transport of Magnesium wasting renal Malaria severa [en.wikipedia.org]

[…] hereditary congenital hypopigmented and hyperpigmented Mad-Mag Mad cow disease Madelung's disease Madokoro Ohdo Sonoda syndrome Maffucci syndrome Mageirocophobia Maghazaji [statemaster.com]

[…] leukocyte inclusions Macular corneal dystrophy Macular degeneration juvenile Macular degeneration, age-related Macular degeneration, polymorphic Macular dystrophy, vitelliform Macules [mindmappedia.com]

Transient Neonatal Pustular Melanosis

Ash leaf macules: Lance-shaped hypopigmented macules on the trunk, arms, or legs, usually associated with tuberous sclerosis. [plasticsurgerykey.com]

Although the lesion in this infant is not localized to the back, a spinal ultrasound was done; it was normal. photo by provided by the parents Hypopigmented Macule Hypopigmented [med.stanford.edu]

Nevus anemicus: A solitary hypopigmented macule resulting from a localized vascular reaction. The surrounding borders classically blanch with pressure. [plasticsurgerykey.com]

Severe Idiopathic Pneumococcemia

Hypopigmented “confetti” macules on the back of a child with tuberous sclerosis.Courtesy of George A. Datto, III, MD. Tuberous sclerosis. [5minuteconsult.com]

Hypopigmented “confetti” macules on the back of a child with tuberous sclerosis.Courtesy of George A. Datto, III, MD. Molluscum contagiosum. [5minuteconsult.com]