Vitiligo
Vitiligo-like lesions, defined as hypopigmented skin lesions, have already been associated with the use of ICIs in particular in patients with malignant melanoma, probably[ncbi.nlm.nih.gov]
Silverberg, Hypopigmenting Disorders, Pediatric Skin of Color, 10.1007/978-1-4614-6654-3_5, (69-88), (2015).[dx.doi.org]
A recent work reported a decreased expression of KGF/FGF7 and its receptor in pathological hypopigmented skin, which may contribute to the formation of the classical milky[frontiersin.org]
Toxic Liver Disease
Ferri’s Clinical Advisor 2018 is the most efficient, intuitive, and thorough resource of its kind, trusted by physicians to provide current diagnosis and treatment recommendations for hundreds of common medical conditions. The renowned "5 books in 1" format organizes vast amounts of data in a user-friendly,[…][books.google.com]
Tuberous Sclerosis
Clinical findings Range from benign hypopigmented skin macules, to profound mental retardation with intractable seizures and premature death due to disease-associated causes[medical-dictionary.thefreedictionary.com]
He additionally had two hypopigmented lesions on the skin. He underwent resection of the left parietal lobe 32months after seizure onset.[ncbi.nlm.nih.gov]
[…] maculae on the skin.[ncbi.nlm.nih.gov]
Phenylketonuria
Four additional cases of PKU diagnosed were siblings of screening detected cases who all presented with mental retardation, microcephaly, hypopigmented hair and skin and seizures[ncbi.nlm.nih.gov]
Hyperphenylalaninemia
Hyperphenylalaninemia is a medical condition characterized by mildly or strongly elevated concentrations of the amino acid phenylalanine in the blood. Phenylketonuria (PKU) can result in severe hyperphenylalaninemia. Phenylalanine concentrations ([phe]) are routinely screened in newborns by the neonatal heel prick[…][en.wikipedia.org]
Prader-Willi Syndrome
Prader–Willi syndrome is a rare, genetic disorder characterized especially by failure to thrive, short stature, mental retardation, hypotonia, functionally deficient gonads, and obesity. The presentation of Prader-Willi syndrome depends upon the age of the patient. In fetal life: Reduced fetal movements and abnormal[…][symptoma.com]
Extensive Burns
Abstract Classic determinants of burn mortality are age, burn size, and the presence of inhalation injury. Our objective was to describe temporal trends in patient and burn characteristics, inpatient mortality, and the relationship between these characteristics and inpatient mortality over time. All patients aged 18[…][ncbi.nlm.nih.gov]
Cartilage Hair Hypoplasia
Cartilage hair hypoplasia is a rare multisystemic genetic disorder demarcated by a short stature from birth, hypoplastic hair, various skeletal abnormalities and a variable degree of immunodeficiency that can be fatal in the absence of an early diagnosis. Clinical signs, results from imaging studies, and genetic testing[…][symptoma.com]
Incontinentia Pigmenti Achromians
We studied a boy with macrocephaly, hypotonia, pigmentary retinopathy, unilateral whorled hypopigmented skin lesions, and seizures.[ncbi.nlm.nih.gov]
[…] derived from a hypopigmented skin area of M.B., with a slowly decreasing tetraploidy rate in the course of passaging: #2 23%, #5 11%, #11 and #14 6% and #18 and #21 2%.[ncbi.nlm.nih.gov]
Hypomelanosis of Ito (HMI) is a very rare birth defect that causes unusual patches of light-colored ( hypopigmented ) skin and may be associated with eye, nervous system,[nlm.nih.gov]
Atopy
Hypopigmented lesions of this disease are usually observed in dark-skinned individuals and often show a T supressor CD8( ) phenotype.[ncbi.nlm.nih.gov]
LL may mimic many different inflammatory and neoplastic skin diseases and in a small percentage of patients, skin manifestation may be atypical.[ncbi.nlm.nih.gov]
Two Caucasian children with predominantly hypopigmented lesions of mycosis fungoides are presented here. Atopy was a concomitant feature in both.[ncbi.nlm.nih.gov]