Hypopigmented Skin Causes & Reasons

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Hypopigmented Skin Symptom Checker: Possible causes include Vitiligo. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.

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Possible Causes

Vitiligo

Vitiligo-like lesions, defined as hypopigmented skin lesions, have already been associated with the use of ICIs in particular in patients with malignant melanoma, probably [ncbi.nlm.nih.gov]

since reduced tanning of normal skin will decrease the contrast with hypopigmented skin.[4] Most patients with nevus depigmentosus do not pursue treatment for their lesion [en.wikipedia.org]

Silverberg, Hypopigmenting Disorders, Pediatric Skin of Color, 10.1007/978-1-4614-6654-3_5, (69-88), (2015). [dx.doi.org]

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Toxic Liver Disease

[…] tyler.treadway@tcpalm.com Published 7:31 AM EDT May 22, 2017 People living in areas with significant blue-green algae blooms, including the Treasure Coast, are more likely to die from nonalcoholic liver disease than those who don't. Martin, St. Lucie, Indian River and Okeechobee counties make up a striking "cluster" with[…] [tcpalm.com]

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Tuberous Sclerosis

Clinical findings Range from benign hypopigmented skin macules, to profound mental retardation with intractable seizures and premature death due to disease-associated causes [medical-dictionary.thefreedictionary.com]

He additionally had two hypopigmented lesions on the skin. He underwent resection of the left parietal lobe 32months after seizure onset. [ncbi.nlm.nih.gov]

TSC is a generic disorder characterized by abnormal skin pigmentations (hypopigmented macules, shagreen patches) and tumor formation in multiple organ systems (brain, heart [med.uth.edu]

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Phenylketonuria

Four additional cases of PKU diagnosed were siblings of screening detected cases who all presented with mental retardation, microcephaly, hypopigmented hair and skin and seizures [ncbi.nlm.nih.gov]

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Hyperphenylalaninemia

Homepage Rare diseases Search Search for a rare disease Hyperphenylalaninemia due to tetrahydrobiopterin deficiency Disease definition Hyperphenylalaninemia (HPA) due to tetrahydrobiopterin (BH4) deficiency, also known as malignant HPA is an amino acid disorder with neonatal onset that is clinically characterized by[…] [orpha.net]

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Prader-Willi Syndrome

Prader–Willi syndrome is a rare, genetic disorder characterized especially by failure to thrive, short stature, mental retardation, hypotonia, functionally deficient gonads, and obesity. The presentation of Prader-Willi syndrome depends upon the age of the patient. In fetal life: Reduced fetal movements and abnormal[…] [symptoma.com]

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Extensive Burns

Acquired factor X deficiency is an extremely rare situation. It has shown to be associated with systemic amyloidosis, respiratory mycoplasma infection, factor X inhibitors, antiphospholipid antibodies, vitamin K deficiency/liver disease as well as the use of certain medications (meropenem, valproic acid). The pathogenesis[…] [ncbi.nlm.nih.gov]

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Cartilage Hair Hypoplasia

Cartilage hair hypoplasia is a rare multisystemic genetic disorder demarcated by a short stature from birth, hypoplastic hair, various skeletal abnormalities and a variable degree of immunodeficiency that can be fatal in the absence of an early diagnosis. Clinical signs, results from imaging studies, and genetic testing[…] [symptoma.com]

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Pityriasis Alba

Preceded by erythematous changes, patches of hypopigmented skin of up to a few centimeters in diameter appear on the upper body. Pruritus may accompany it. [ncbi.nlm.nih.gov]

Pityriasis alba is a common skin disorder of patches of light-colored (hypopigmented) areas. The cause is unknown but may be linked to atopic dermatitis (eczema). [nlm.nih.gov]

It is more noticeable in children with dark skin. Definition Pityriasis alba is a common skin disorder of patches of light-colored (hypopigmented) areas. [account.allinahealth.org]

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Incontinentia Pigmenti Achromians

[…] derived from a hypopigmented skin area of M.B., with a slowly decreasing tetraploidy rate in the course of passaging: #2 23%, #5 11%, #11 and #14 6% and #18 and #21 2%. [ncbi.nlm.nih.gov]

We studied a boy with macrocephaly, hypotonia, pigmentary retinopathy, unilateral whorled hypopigmented skin lesions, and seizures. [ncbi.nlm.nih.gov]

Hypomelanosis of Ito (HMI) is a very rare birth defect that causes unusual patches of light-colored ( hypopigmented ) skin and may be associated with eye, nervous system, [nlm.nih.gov]

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Ermine Phenotype

Affiliated tissues include skin, and related phenotypes are sensorineural hearing impairment and hypopigmented skin patches [malacards.org]

Showing of 22 80%-99% of people have these symptoms Hypopigmentation of hair Loss of hair color 0005599 Hypopigmented skin patches Patchy loss of skin color 0001053 Sensorineural [rarediseases.info.nih.gov]

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Dyschromatosis symmetrica hereditaria

Hyperpigmented hair was also found in normal and hypopigmented skin. The colors of the hair and the skin did not correlate. [ncbi.nlm.nih.gov]

(c) In the hyperpigmented skin, regularly distributed melanocytes (M) are observed on the basal layer. (d) In the hypopigmented skin, The Journal of Dermatology Wiley [deepdyve.com]

The hair on the forearm of the affected father became longer, larger in diameter, and hypopigmented (white) after age 40 years. [ncbi.nlm.nih.gov]

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Piebaldism

Patches of hypopigmented skin and hair in these disorders represent regions lacking in melanocytes, the result of defective melanoblast differentiation, migration, proliferation [ncbi.nlm.nih.gov]

Piebaldism is an autosomal dominant trait that causes patches of non pigmented and hypopigmented skin cells to develop. [lybrate.com]

[…] of hypopigmented and depigmented skin areas (leukoderma) on various parts of the body, preferentially on the forehead, chest, abdomen, upper arms, and lower extremities, [orpha.net]

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Dyschromatosis Universalis Hereditaria 1

skin patches and hyperpigmented/hypopigmented macules. [selfdecode.com]

Additionally, many immature melanosomes were observed in hypopigmented skin region. [journals.plos.org]

Abstract Dyschromatosis is a pigmentary genodermatosis which presents with hyper and hypopigmented skin lesions giving a mottled appearance. [e-ijd.org]

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Atopy

Hypopigmented lesions of this disease are usually observed in dark-skinned individuals and often show a T supressor CD8( ) phenotype. [ncbi.nlm.nih.gov]

LL may mimic many different inflammatory and neoplastic skin diseases and in a small percentage of patients, skin manifestation may be atypical. [ncbi.nlm.nih.gov]

Two Caucasian children with predominantly hypopigmented lesions of mycosis fungoides are presented here. Atopy was a concomitant feature in both. [ncbi.nlm.nih.gov]

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Microcephalic Osteodysplastic Primordial Dwarfism Type II

0000958 Full cheeks Apple cheeks Big cheeks Increased size of cheeks Large cheeks [ more ] 0000293 Hypopigmented skin patches Patchy loss of skin color 0001053 Joint hyperflexibility [rarediseases.info.nih.gov]

[…] female external genitalia Abnormal female external genitalia 0000055 Aplasia/Hypoplasia of the eyebrow Absence of eyebrow Lack of eyebrow Missing eyebrow [ more ] 0100840 Dry skin [rarediseases.info.nih.gov]

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Acne Vulgaris

These patients compulsively pick at their skin, creating more damage than the original acne. [racgp.org.au]

Rarely, patients, predominantly young women, present with minimal acne but significant visible cutaneous damage from picking and scratching, frequently leaving many hypopigmented [racgp.org.au]

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Limited Cutaneous Systemic Scleroderma

In the hypopigmented skin, multiple microscopic sections were devoid of melanocytes, with no melanin in adjacent basal cells. [ncbi.nlm.nih.gov]

Management is aimed at treating the symptoms present in each affected individual. 0002960 Hypopigmented skin patches Patchy loss of skin color 0001053 Narrow foramen obturatorium [rarediseases.info.nih.gov]

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Dermatitis

The skin is pink and shiny with surface cracks. In darker skin: affected areas may look lighter (hypopigmented) or darker (hyperpigmented) than surrounding skin. [bad.org.uk]

Chronic eczema can present as lesions that are pruritic, hyperpigmented and/or hypopigmented, well-defined plaques of previously inflamed skin, a scaly appearance and lichenification [podiatrytoday.com]

In the skin folds: it often affects moist areas such as the skin under the breasts, in the groin, under the arms, or in folds of skin on the abdomen. [bad.org.uk]

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Tinea Versicolor

Hyperpigmented skin had thicker stratum corneum than hypopigmented but both were thicker than the uninvolved skin. [ncbi.nlm.nih.gov]

The hyperpigmented skin showed the stratum corneum to be leaner than in the hypopigmented skin, but in both the stratum corneum was thinner than in non-affected skin. [scielo.br]

Abstract A comparative histopathologic study is made between the hypopigmented and hyperpigmented skin lesions of pityriasis versicolor and normal skin areas utilizing histochemical [ncbi.nlm.nih.gov]

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Acromelanosis

Light microscopic findings of hyper- and hypopigmented skin were similar to those of normal skin, except that background staining of keratinocytes in dark and light macules [findzebra.com]

Abstract Dyschromatosis is a pigmentary genodermatosis which presents with hyper and hypopigmented skin lesions giving a mottled appearance. [e-ijd.org]

There was no atrophy of skin or loss of epidermal ridges over the lesions. There were no similar lesions elsewhere on the body. [ijdvl.com]

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Atopic Dermatitis

Increased skin markings may also be present on the neck and palms of the hands. [journals.lww.com]

Atopic eczema may have a slight hypopigmented characteristic (pityriasis alba) that is common on the face of children. [journals.lww.com]

External stroking of the skin can produce white dermatographism especially over the scapular area where prestored mediators including histamine are not depleted. [journals.lww.com]

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Klein-Waardenburg Syndrome

Hypopigmented skin patches are sometimes present but not all patients have them. Genetics The uniqueness of Waardenburg syndrome types 1 and 3 remains to be established. [disorders.eyes.arizona.edu]

Hypopigmented patches of skin are more susceptible to sun damage, so sun protection is important. What is the outcome for Waardenburg syndrome? [dermnetnz.org]

Individuals with type 1 often have a white forelock (29%), premature graying (44%), and hypopigmented skin patches (55%). A few patients have cleft palate and/or lip. [disorders.eyes.arizona.edu]

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Dyschromatosis Universalis Hereditaria

Additionally, many immature melanosomes were observed in hypopigmented skin region. [journals.plos.org]

Abstract Dyschromatosis is a pigmentary genodermatosis which presents with hyper and hypopigmented skin lesions giving a mottled appearance. [e-ijd.org]

DUH is characterized by mixtures of hyperpigmented- and hypopigmented macules all over the body. Skin lesions are usually present in the first years of life. [sparrho.com]

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Contact Dermatitis

Subacute forms of dermatitis present as less intense pruritic, erythematous, scaling and fissured skin rash. [podiatrytoday.com]

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Hemolytic Anemia

He later presented with hypopigmented skin lesions and atrophy post-photosensitivity, persistent red-colored urine and hepatosplenomegaly. [ncbi.nlm.nih.gov]

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Thrombocytopenia

Usually findings are confined to the eyes, but skin may be hypopigmented. Patients with OA1 may have late-onset sensorineural deafness. [merck.com]

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Cutaneous Candidiasis

hypopigmented, atrophic plaques on the genitalia, trunk, and axillae Neoplasms Bowen disease Solitary, enlarging, erythematous, well-defined plaque Paget disease Erythematous [aafp.org]

[…] nigricans Hyperpigmentation with velvety, thickened skin, predominantly on posterior neck and body folds Hidradenitis suppurativa Chronic condition of apocrine gland–bearing skin [aafp.org]

[…] in the axillae or anogenital region; deep abscesses and old scars Intertrigo Pruritic regions of erythema and peripheral scaling between skin folds Lichen sclerosus Well-demarcated [aafp.org]

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Balanitis

[…] screened as they may have a high rate of infection. 7 Pityriasis versicolor This condition is caused by the yeast Malassezia furfur, and has an incidence of 0.5-1% of all skin [cirp.org]

[…] disease in England, but up to 50% in tropical areas. 13 Genital involvement is uncommon and presents as a discrete, circinate, finely scaling hypopigmented areas on the glans [cirp.org]

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Balanoposthitis

[…] screened as they may have a high rate of infection.7 Pityriasis versicolor This condition is caused by the yeast Malassezia furfur, and has an incidence of 0.5-1% of all skin [cirp.org]

[…] disease in England, but up to 50% in tropical areas.13 Genital involvement is uncommon and presents as a discrete, circinate, finely scaling hypopigmented areas on the glans [cirp.org]

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