Create issue ticket

2,543 Possible Causes for Hypoplasia of Labia Majora, Palmar Hyperlinearity, Skin Thickening

  • Ichthyosis Vulgaris

    Symptoms may include any of the following: Dry skin, severe Scaly skin ( scales ) Possible skin thickening Mild itching of the skin The dry, scaly skin is usually most severe[nlm.nih.gov] The main characteristics of IV are fine-scale on the arms and legs, palmar hyperlinearity, and keratosis pilaris.[ncbi.nlm.nih.gov] As older skin cells build up on the skin’s surface, the skin thickens and becomes scaly.[wederm.com]

    Missing: Hypoplasia of Labia Majora
  • Atopic Dermatitis

    Skin thickening and plaque formation is dependent on habitual scratching.[emedicine.medscape.com] Among patients, reduced level of monomeric filaggrin and NMF correlated with the presence of FLG mutations and clinical phenotypes such as xerosis, palmar hyperlinearity and[ncbi.nlm.nih.gov] […] children Flexure lichenification in older children and adults Minor features Eyes Cataracts (anterior subcapsular) Keratoconus Infraorbital folds affected Facial pallor Palmar[aafp.org]

    Missing: Hypoplasia of Labia Majora
  • Ichthyosis

    As older skin cells build up on the skin’s surface, the skin thickens and becomes scaly.[wederm.com] Palms and soles show accentuated creases and when affecting the palms this sign is referred to as palmar hyperlinearity or as “ichthyosis palms”.[medizin.uni-muenster.de] Symptoms Dry skin, severe Scaly skin ( scales ) Possible skin thickening Mild itching of the skin The dry, scaly skin is usually most severe on the legs.[nicklauschildrens.org]

    Missing: Hypoplasia of Labia Majora
  • Rapp-Hodgkin Syndrome

    majora Narrow nose Fine hair Pulmonary hypoplasia Narrow mouth Depressivity Abnormality of T cell physiology Progressive alopecia Neoplasm Parathyroid hypoplasia Reduced[mendelian.co] Increased numbers and depth of skin lines on the palms may also occur (hyperlinearity). Hyperkeratosis may also affect the knees and elbows.[rarediseases.org] .  Skin thickening beneath free edges of nails,finger joints,knuckles  Thickening of skull bones,tufting of terminal phalanges of fingers and nails  Oral leukoplakia may[de.slideshare.net]

  • X-Linked Ichthyosis

    The proband (ǁǀ5) is a 9 year-old boy with generalized dry and grey brown scales, without involvement of the palms, soles and face, and no palmar hyperlinearity, accompanied[ijdvl.com] Dermatological examination revealed that the skin over the patient's entire body was dry and coarse, with thickening and scaling of the skin in the extensor side of the extremities[ncbi.nlm.nih.gov] […] keratoderma in LK ( LOR ). ( f ) Palmar hyperlinearity in IV ( FLG ). ( g ) Generalized fine scaling phenotype with concomitant severe erythema in NS ( SPINK5 ). ( h ) Onychoschisis[ncbi.nlm.nih.gov]

    Missing: Hypoplasia of Labia Majora
  • Gorlin-Chaudhry-Moss Syndrome

    Initial syndromic features: Erythematous skin lesions, clubbed fingers, periosteal thickening and cardiac insufficiency.[vivavoceoralmedicineradiology.com] […] of labia majora,, Gorlin-Chaudhry-Moss syndrome, Moved to 612289, craniofacial dysostosis, patent ductus arteriosus, hypertrichosis, hypoplasia of labia majora, dental and[monarchinitiative.org] Affected females have unusually small external genital folds (hypoplasia of the labia majora).[ghr.nlm.nih.gov]

    Missing: Palmar Hyperlinearity
  • Popliteal Pterygium Syndrome

    Minimal skin syndactyly of digits 2/3/4 on the left hand was present.[jmg.bmj.com] […] of the labia majora, malformation of the scrotum, and cryptorchidism.[en.wikipedia.org] They may have abnormal genitals, including unusually small external genital folds (hypoplasia of the labia majora) in females.[ghr.nlm.nih.gov]

    Missing: Palmar Hyperlinearity
  • Rosacea

    Skin thickening: In some cases of rosacea, the skin might thicken and enlarge from excess tissue, resulting in a condition called rhinophyma.[my.clevelandclinic.org] The central facial skin may be rough, and thus appear to be very dry. Plaques. Raised red patches may develop without changes in the surrounding skin. Skin thickening.[webmd.com] Dry appearance: The central facial skin might be rough, and thus appear to be very dry.[my.clevelandclinic.org]

    Missing: Hypoplasia of Labia Majora Palmar Hyperlinearity
  • Inherited Ichthyosis

    As older skin cells build up on the skin’s surface, the skin thickens and becomes scaly.[wederm.com] […] keratoderma in LK ( LOR ). ( f ) Palmar hyperlinearity in IV ( FLG ). ( g ) Generalized fine scaling phenotype with concomitant severe erythema in NS ( SPINK5 ). ( h ) Onychoschisis[nature.com] Symptoms may include any of the following: Dry skin, severe Scaly skin ( scales ) Possible skin thickening Mild itching of the skin The dry, scaly skin is usually most severe[medlineplus.gov]

    Missing: Hypoplasia of Labia Majora
  • Mucopolysaccharidosis

    Thickened skin and mild changes in facial features, bone, and skeletal structures become noticeable with age. Growth in height usually stops by age 10.[en.wikipedia.org] Skin Tough, thickened skin in individuals with MPS I often makes needle sticks difficult. Examine optic nerve for compression and atrophy.[medicalhomeportal.org] A distinctive facies with thickening of lips and nostrils as well as an enlarged and protruding tongue forms slowly and may become evident between 2-4 years of age, later[orpha.net]

    Missing: Hypoplasia of Labia Majora Palmar Hyperlinearity

Similar symptoms