Hypoplastic Nails: Causes & Reasons

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Possible Causes for Hypoplastic Nails

Nail-Patella Syndrome

The most commonly seen clinical features are iliac horns (seen in 80% of cases), nail hypoplasia or aplasia, absent or hypoplastic patellae – with varying degrees of subluxation [jmedicalcasereports.biomedcentral.com]

The most common clinical findings are a hypoplastic patella, elbow dysplasia, iliac horns, and hypoplastic nails. [insights.ovid.com]

[…] doi: 10.2106/JBJS.JOPA.17.00004 Review Article Abstract Author Information Authors Article Metrics Metrics Nail-patella syndrome (NPS) is an autosomal-dominant dysmorphic [journals.lww.com]

Turner Syndrome

In infants, the combination of dysplastic or hypoplastic nails and lymphedema gives a characteristic sausage-like appearance to the fingers and toes. [emedicine.medscape.com]

Other characteristic physical findings These may include the following: Dental: A high arched palate, sometimes with dental crowding or malocclusion Nails: Hypoplastic or [emedicine.medscape.com]

[…] hyperconvex nails Nevi: Excessive numbers of nevi, when compared to other family members Webbed neck: A broad neck and a low or indistinct hairline Cubitus valgus (increased [emedicine.medscape.com]

Epidermolysis Bullosa

The nails are deformed or absent. The teeth are hypoplastic, and extensive caries develop early in life. Death may occur in early life. Case Reports Case I: M. [pubs.rsna.org]

Hypoplastic enamel formation causes tooth decay. Nail dystrophy and alopecia are also common. They have a normal life expectancy and ability to reproduce. [patient.info]

Trachonychia

[…] or absent • Renal involvement • Infection • Chronic paronychia caused by • Dorsal pterygium – Proximal nail fold scarring – Ventral nail plate and hyponychium fused – Congenital [brainscape.com]

Steatocystoma multiplex • Natal teeth • No leukokeratosis • I, II, III and laryngeal disease, MR and amyloid Acute paronychia cause #1 – Proximal white subungual • Patellae hypoplastic [brainscape.com]

Ellis-Van Creveld Syndrome

Ellis-van Creveld (EVC) syndrome is a rare autosomal recessive disorder characterized by hypoplastic nails, polydactyly, and achondroplasia. [ncbi.nlm.nih.gov]

nails. [ncbi.nlm.nih.gov]

Clinical features were: a marked acromesomelic short stature (135 cm height), narrow thorax, genu valgum, club feet, brachydactyly, malposed toes, hypoplastic nails and teeth [ncbi.nlm.nih.gov]

Onycholysis

[…] condition that includes hypoplastic, easily dislocated patellas, renal and skeletal abnormalities, and glaucoma. [aafp.org]

Koilonychia also may result from trauma, constant occupational exposure of the hands to petroleum-based solvents, or nail-patella syndrome. 11 The latter is an autosomal-dominant [aafp.org]

Hidrotic Ectodermal Dysplasia

[…] sebaceous glands hypoplastic-absent eccrine sweat glands spoon-shaped nails hypotrichosis fine, brittle hair scanty hair absent or scanty eyelashes and eyebrows blonde, fine [humpath.com]

hypoplasia and nail deformities; skin hyperpigmentation, particularly over the joints; normal teeth; and palmoplantar keratoderma. [genedx.com]

ECTD2 is an autosomal dominant condition characterized by atrichosis, nail hypoplasia and deformities, hyperpigmentation of the skin, normal teeth, normal sweat and sebaceous [uniprot.org]

Iron Deficiency Anemia

Abstract Ankaferd Blood Stopper (ABS) comprises a mixture of plants and stops bleeding via forming a protein network by erythroid aggregation. Bleeding causes reduction of iron levels in body. It has been indicated that ABS contains significant amount of iron. Thus, we investigated the biological activity of[…] [ncbi.nlm.nih.gov]

Psoriasis

Signs and symptoms of psoriasis may include the following: Family history of similar skin condition Pruritus (mostly seen in eruptive, guttate psoriasis) Cutaneous erythematous plaques, pustules or small papules Erythema and scaling Joint pain Pain (mostly seen in erythrodermic psoriasis and in some instances of[…] [symptoma.com]

Distal Symphalangism

[…] hypoplasia/flat/short midface Thin/hyperconvex/hypoplastic nails Paresis of ocular muscles/squint Decreased hair pigmentation - patchy Short foot (including brachydactyly [head-face-med.biomedcentral.com]

The index finger is affected most typically, but reports of thumb and great toe involvement, with or without nail hypoplasia, have appeared in the literature (Matthews et [rrnursingschool.biz]

[…] carpals Hypertelorism Dental caries Other dental abnormality Absent/decreased eyebrows/lateral thinning Abnormal tooth position/malocclusion/open bite Thin/hyperconvex/hypoplastic [head-face-med.biomedcentral.com]

Cronkhite-Canada Syndrome

Cronkhite-Canada syndrome (CCS) is a rare disorder characterized by generalized gastrointestinal polyps, alopecia, nail changes and hyperpigmentation. In many cases, the symptoms appear in the following order: Gastrointestinal symptoms Weight loss Weakness Edema Ectodermal changes The ectodermal changes occur[…] [symptoma.com]

Plummer-Vinson Syndrome

Plummer-Vinson syndrome is a condition that affects mostly middle-aged caucasian women and is defined by the triad of iron deficiency anemia, upper esophageal webs and postcricoid dysphagia. Given that it can involve iron deficiency (sideropenia) without anemia, it has been also called sideropenic dysphagia. Dysphagia[…] [symptoma.com]

Peripheral Vascular Disease

Peripheral vascular disease, abbreviated as PVD, is a condition characterized by obstruction of large arteries, causing the blood supply to reduce significantly. Such a type of condition is also referred to as Peripheral arterial disease. Intermittent claudication, characterized by pain in leg, experienced while walking,[…] [symptoma.com]

Onychia

[…] onychia - o. maligna acute o. occurring spontaneously in debilitated patients, or in response to slight trauma. - o. sicca a condition characterized by brittle nails. * * * onych·ia ō-'nik-ē-ə n inflammation of the matrix of a nail often leading to suppuration and loss of the nail * * * onych·ia (o-nikґe- ə ) [ onych-[…] [medicine.academic.ru]

Psoriatic Arthritis

Abstract A middle-aged man presented for left foot diabetic ulcer care. Pedal radiographs were negative for signs of osteomyelitis. However, asymptomatic incidental osseous findings demonstrated significant plantar and posterior calcaneal spurring possibly consistent with diffuse idiopathic skeletal hyperostosis[…] [ncbi.nlm.nih.gov]

Hypoparathyroidism

Hypoparathyroidism NORD gratefully acknowledges Dolores Shoback, MD, Professor of Medicine, UCSF Endocrine Research Unit - 111N, SF - VA Medical Center, for assistance in the preparation of this report. Subdivisions of Hypoparathyroidism acquired hypoparathyroidism autoimmune hypoparathyroidism congenital[…] [rarediseases.org]

Juvenile Myxedema

The thoroughly updated Twelfth Edition of this classic retains the organization, practicality, and readability that makes Merritt's Neurology one of the most popular texts among neurologists, primary care physicians, and residents reviewing for psychiatry or neurology boards. In 183 short chapters, the book provides[…] [books.google.de]

Myxedema

Myxedema coma occurs as a result of long-standing, undiagnosed, or undertreated hypothyroidism and is usually precipitated by a systemic illness. Myxedema coma can result from any of the causes of hypothyroidism, most commonly chronic autoimmune thyroiditis. It can also occur in patients who had thyroidectomy or[…] [emedicine.com]

Secondary Syphilis

Anetoderma is a rare benign condition of diverse etiology whose characteristic is the diminution or absence of the dermal elastic fibers. Classified as primary and secondary, the latter associated with tumors, inflammatory, and infectious diseases. Although the etiology of the lesions is well described in literature,[…] [ncbi.nlm.nih.gov]

Rapp-Hodgkin Syndrome

and conical teeth and hypodontia, and hypospadias and hypoplastic uvula in the boy. [unboundmedicine.com]

Oral findings may include hypodontia, hypoplastic enamel, cleft lip/palate, and a pronounced midfacial hypoplasia. [ncbi.nlm.nih.gov]

[…] teeth * Low nasal bridge * Narrow nose * Hypoplastic nostrils * Maxillary hypoplasia * High forehead * Small mouth * Cleft lip * Cleft palate * Cleft palate * Cleft uvula [checkorphan.org]

Schöpf-Schulz-Passarge Syndrome

It is characterized by palmoplantar keratoderma, eyelid apocrine hydrocystomas, hypodontia, hypotrichosis and hypoplastic nails. [karger.com]

(onychodystrophy), such as nail fragility or hypoplastic nails. [dermnetnz.org]

[…] middle-age Thickening of the skin on the hands and the feet (palmoplantar keratoderma) Excessive sweating (hyperhidrosis) Sparse hair (hypotrichosis) Malformation of the nails [dermnetnz.org]

Adams-Oliver Syndrome

The full spectrum of observed defects ranges from hypoplastic nails, cutaneous syndactyly, bony syndactyly, transverse reduction defects, zygodactyly, ectrodactyly, polydactyly [escholarship.org]

A male infant with scalp and skin cutis aplasia, generalized cutis aplasia, dilated veins over scalp and trunk, hypoplastic toes and nails of feet, glaucoma, poor feeding [pagepress.org]

Wiedemann-Rautenstrauch Syndrome

There was generalized lack of subcutaneous fat, thin wrinkled skin, and hypoplastic nails. [omim.org]

Williams-Beuren Syndrome

nails, short stature, microcephaly, hypotonia, developmental delay, hyperacusis, mental retardation, overfriendliness, hyperactivity, anxiety, and loquaciousness. [scielo.br]

nails showed a significant association on univariate analysis at a = 0.05, but the P values were closer to the a value than the value corrected for Bonferroni's error; these [scielo.br]

[…] coarctation, non-SVA congenital heart disease, umbilical/inguinal hernia, kidney anomalies, arterial hypertension, hypercalcemia, joint contractures, fifth finger clinodactyly, hypoplastic [scielo.br]

Curry-Hall Syndrome

[…] toenails Underdeveloped toenails 0001800 Mild short stature 0003502 Nail dystrophy Poor nail formation 0008404 Postaxial hand polydactyly Extra little finger Extra pinkie [rarediseases.info.nih.gov]

[…] toenails Oval face Enuresis nocturna Abnormality of the dentition Protruding ear Nail dystrophy Hypodontia Nail dysplasia Postaxial hand polydactyly Hypotelorism Abnormality [mendelian.co]

[…] teeth Early eruption of teeth 0006288 Conical tooth Cone shaped tooth Shark tooth [ more ] 0000698 Hypodontia Failure of development of between one and six teeth 0000668 Hypoplastic [rarediseases.info.nih.gov]

Santos Syndrome

MalaCards integrated aliases for Santos Syndrome: Name: Santos Syndrome 57 70 Fibular Agenesis/hypoplasia, Oligodactylous Clubfeet, and Anonychia/nail Hypoplasia Syndrome [malacards.org]

[…] phalanx more Skeletal Limbs: acromial dimples genua valga limited extension, flexion, pronation and/or supination of the forearm and/or hand fibular agenesis/hypoplasia hypoplastic [malacards.org]

[…] femora more Skeletal Feet: talipes equinovarus oligodactyly clubfeet pes metatarsus varus Skin Nails Hair Nails: anonychia ungual hypoplasia Clinical features from OMIM®: [malacards.org]

BIDS Syndrome

Other features of this syndrome are low birth weight, short stature, mental retardation, delayed neuromuscular development and other CNS anomalies, dysplasia of nails, hypoplasia [link.springer.com]

Many TTD patients also have nail findings, including but not limited to onychodystrophy, brittle nails, hypoplasia, koilonychia, onychoschizia (nail splitting), and ridging [dermatologyadvisor.com]

Ectodermal Dysplasia Type 5 Hair Nail

Additional features, such as dry skin, scaly skin, frontal bossing, saddle nose, hypertelorism, nail dystrophy, hypoplastic maxilla, protuberant lips, palmoplantar keratosis [digitmedicine.com]

Orofacial characteristics of this syndrome include anodontia or hypodontia, hypoplastic conical teeth, underdevelopment of the alveolar ridges, frontal bossing, a depressed [amhsr.org]

[…] diabetes insipidus Facial abnormalities of affected individuals may include: cleft lip cleft palate malformed ears Additionally, individuals affected with EEC can experience nail [encyclopedia.com]

Fetal Hydantoin Syndrome

The nails generally reflect the size and shape of the underlying distal phalanx (e.g., hypoplastic nail, narrow hyperconvex nail, short broad nail). Figure 1.100. [rrnursingschool.biz]

Fetal Hydantoin syndrome mnemonic - PHENytoin Fetal hydantoin syndrome involves microcephaly, dysmorphic craniofacial features, hypoplastic nails, hypoplastic distal phalanges [medicowesome.com]

nails and distal phalanges ( birth defects ). [ipfs.io]

BOD Syndrome

nails, especially on the fifth digit of each extremity, which were more noticeable on the feet, coarse face, broad nose, wide mouth, thick eyebrows, long eyelashes, accommodative [bio2rdf.org]

The clinical profile of our case includes all the three major criteria in form of 1.absence of nail and distal phalanx of left little finger and hypoplastic nails of both [annalspc.com]

Similarities: absent or hypoplastic patellae, limited elbow supination, abnormal nails 2. [doi.org]