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2,252 Possible Causes for Hypoplastic Pons, Onset of Symptoms in First or Second Decade of Life, Psychomotor Retardation

  • Congenital Muscular Dystrophy

    Magnetic resonance imaging of the brain at 3.5 years of age showed increased T2 signal from supratentorial and infratentorial white matter, a hypoplastic pons and subcortical[ncbi.nlm.nih.gov] The onset of symptoms usually occurs in the first or second decade of life. Affected individuals usually present with impairment of upper extremity elevation.[icd10data.com] […] midbrain, vermian hypoplasia /- cephalocele Described features in general include: cobblestone brain myelination defects Z-shaped brainstem/hypoplastic vermis ventriculomegaly[radiopaedia.org]

  • Lissencephaly

    The corticospinal tract was hypoplastic in the one ARX mutant brain with pons present for examination, but normal numbers of basis pontine neurons were present.[doi.org] Symptoms of the disorder may include unusual facial appearance, difficulty swallowing, failure to thrive, muscle spasms, seizures, and severe psychomotor retardation.[ninds.nih.gov] MR imaging of a patient with epilepsy and psychomotor retardation at 5 months revealed parieto-occipital pachygyria with almost normal cortical appearance and thickness in[ncbi.nlm.nih.gov]

    Missing: Onset of Symptoms in First or Second Decade of Life
  • Hallervorden-Spatz Syndrome

    There is an early onset classic form with symptoms of extrapyramidal disease beginning in the first decade of life and rapid progression to loss of ambulation in about 15[disorders.eyes.arizona.edu] Others with atypical disease may not have symptoms until the second or third decades.[disorders.eyes.arizona.edu]

    Missing: Hypoplastic Pons
  • Amish Lethal Microcephaly

    retardation, intractable epilepsy, and liver failure in infants and young children.[mendelian.co] 4A (ALPERS TYPE); MTDPS4A Mitochondrial DNA depletion syndrome-4A, also known as Alpers syndrome, is an autosomal recessive disorder characterized by a clinical triad of psychomotor[mendelian.co]

    Missing: Onset of Symptoms in First or Second Decade of Life
  • Polymicrogyria

    pons and cerebellar dysplasia are key features for the diagnosis of TUBA1A-related PMG.[ncbi.nlm.nih.gov] We describe two children from a consanguineous family who manifested mega-corpus callosum, polymicrogyria, and psychomotor retardation.[ncbi.nlm.nih.gov] Reviewing the literature, we speculate that MegaCC, psychomotor retardation and anomalies in cortical migration are the three pathognomonic features.[ncbi.nlm.nih.gov]

    Missing: Onset of Symptoms in First or Second Decade of Life
  • Depression

    This is called psychomotor retardation.[health.com] Changes in Activity or Energy Level Physical Changes Caused by Depression Unexplained aches and pains Weight loss or gain Decreased or increased appetite Psychomotor agitation[verywell.com] Psychomotor agitation or retardation nearly every day. Fatigue or loss of energy nearly every day.[depression.org]

    Missing: Hypoplastic Pons Onset of Symptoms in First or Second Decade of Life
  • Acrocallosal Syndrome

    The pons and the cerebellum were hypoplastic. The dentate nuclei were fragmented.[ncbi.nlm.nih.gov] The large majority of ACS patients have intellectual deficit that is severe in 80% of cases, and substantial psychomotor retardation.[orpha.net] At the level of the pons, the tegmentum was only mildly atrophic, whereas the basis pontis was severely narrowed.[redorbit.com]

    Missing: Onset of Symptoms in First or Second Decade of Life
  • Endogenous Depression

    It is generally accepted that endogenous depression includes marked vegetative changes, such as loss of appetite, loss of weight, loss of sleep, psychomotor retardation or[link.springer.com] […] score, presumably measuring mainly depressive mood and psychomotor retardation.[ncbi.nlm.nih.gov] […] depression major depressive disorder characterized by signs and symptoms of psychomotor retardation, such as burdened movements and slowed, toneless speech. en·dog·e·nous[medical-dictionary.thefreedictionary.com]

    Missing: Hypoplastic Pons Onset of Symptoms in First or Second Decade of Life
  • Reactive Depression

    […] depression major depressive disorder characterized by signs and symptoms of psychomotor retardation, such as burdened movements and slowed, toneless speech. re·ac·tive de[medical-dictionary.thefreedictionary.com] “A patient who has psychomotor retardation, hypersomnia, and gaining weight is scored as having identical symptoms as another who is agitated, sleeping badly, and has weight[theatlantic.com] It is often identified with a specific symptom complex—psychomotor retardation, early morning awakening, weight loss, excessive guilt, and lack of reactivity to the environment—that[medical-dictionary.thefreedictionary.com]

    Missing: Hypoplastic Pons Onset of Symptoms in First or Second Decade of Life
  • Congenital Merosin-Positive Muscular Dystrophy

    […] midbrain, vermian hypoplasia /- cephalocele Described features in general include: cobblestone brain myelination defects Z-shaped brainstem/hypoplastic vermis ventriculomegaly[radiopaedia.org] The onset of symptoms usually occurs in the first or second decade of life. Affected individuals usually present with impairment of upper extremity elevation.[icd10data.com] , microcephaly, delayed psychomotor development, generalized muscular wasting and weakness with mild facial involvement, calf pseudohypertrophy, joint contractures and areflexia[discovery.ucl.ac.uk]

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