Hypoproteinemia: Causes & Reasons

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Possible Causes for Hypoproteinemia

Cronkhite-Canada Syndrome

Dysgeusia was recognized and the degree of hypoproteinemia was remarkable. A barium enema study and colonofiberscopy also revealed an advanced cancer in the rectum. [ncbi.nlm.nih.gov]

Hypoproteinemia and ectodermal changes improved postoperatively. Surgery is an effective treatment for protein-losing enteropathy in Cronkhite-Canada syndrome. [ncbi.nlm.nih.gov]

Diffuse gastrointestinal polyposis associated with hypoproteinemia. J Roy Coll. Surg Edinb 12:149. 1967. 8. Kyriakos M, Condon SC. Enteritis cystica profunda. [kjim.org]

Intestinal Lymphangiectasia

Primary intestinal lymphangiectasia (PIL) is a rare disease of intestinal lymphatics presenting with hypoproteinemia, bilateral lower limb edema, ascites, and protein losing [ncbi.nlm.nih.gov]

The diagnosis of PIL was finally confirmed by severe hypoproteinemia, endoscopic changes, and histology of jejunum biopsy. [ncbi.nlm.nih.gov]

May result in a protein-losing enteropathy with hypoproteinemia, diarrhea, edema, ascites and weight loss. [medical-dictionary.thefreedictionary.com]

Gastropathy

The authors report an 11-year-old boy with generalised oedema and hypoproteinemia. [ncbi.nlm.nih.gov]

The patients, when seen, are usually in acute abdominal pain and vomiting or edema due to hypoproteinemia is present. [ncbi.nlm.nih.gov]

We herein report the case of a 43-year-old man with distinct gastropathy and hypoproteinemia treated with H. pylori eradication therapy. [ncbi.nlm.nih.gov]

Protein-Losing Enteropathy

Although her seizures diminished, her course was complicated by hypoproteinemia. [ncbi.nlm.nih.gov]

Laboratory findings revealed severe hypoproteinemia with normal liver, renal, thyroid and adrenal functions and no proteinuria. [ncbi.nlm.nih.gov]

The diagnosis of PLE should be considered in patients with hypoproteinemia after other causes, such as malnutrition, proteinuria, and impaired protein synthesis due to cirrhosis [mayoclinic.pure.elsevier.com]

Capillary Leak Syndrome

Laboratory values showed hypoproteinemia. IL-11 was stopped and human albumin was transfused at a rate of 10 g per day. [ncbi.nlm.nih.gov]

Blood laboratory data revealed severe hypoproteinemia with a small monoclonal IgG-kappa protein. These findings suggested strongly the diagnosis of SCLS. [ncbi.nlm.nih.gov]

This syndrome is a rare condition characterized by recurrent episodes of hypotension with hemoconcentration and hypoproteinemia. [ncbi.nlm.nih.gov]

Hypertrophic Gastritis

[…] antifibrinolytic therapy with oral tranexamic acid (trans-4-aminomethyl cyclohexane carboxylic acid; trans-AMCHA), and four of the patients showed marked improvement of their hypoproteinemia [ncbi.nlm.nih.gov]

Hypoproteinemia may lead to ascites and pleural effusions. The exact etiology is not well known. [radiopaedia.org]

Remission can occur after parietal cell vagotomy or histamine-H 2 -receptor blockade, or spontaneously; however, in most patients, rugal enlargement and hypoproteinemia persist [annals.org]

Hyperproteinemia

DECREASE IN ALL FRACTIONS OF PROTEINS HYPOPROTEINEMIA Hypoproteinemia occurs in the following conditions: 1. Hemorrhage 2. Extensive burns 3. Pregnancy 4. [nhealthcare.blogspot.com]

Q.2 – What are the causes of hypoproteinemia? [namrata.co]

Of the individual serum proteins, albumin is present in such high concentrations that low levels of this protein alone may cause hypoproteinemia. [mayomedicallaboratories.com]

Anasarca

Laboratory evaluation revealed iron deficiency along with hypoproteinemia and hypoalbuminemia. [ncbi.nlm.nih.gov]

Abstract INTRODUCTION During the course of treatment of a patient with reticulum cell sarcoma, a reversible syndrome consisting of anasarca and hypoproteinemia but without [annals.org]

Primary Intestinal Lymphangiectasia

The diagnosis of PIL was finally confirmed by severe hypoproteinemia, endoscopic changes, and histology of jejunum biopsy. [ncbi.nlm.nih.gov]

Primary intestinal lymphangiectasia (PIL) is a rare disease of intestinal lymphatics presenting with hypoproteinemia, bilateral lower limb edema, ascites, and protein losing [ncbi.nlm.nih.gov]

Demonstration of gastrointestinal protein loss as a cause of hypoproteinemia, which can differentiate from other causes of hypoproteinemia, is essential to make the diagnosis [kjim.org]

Citrullinemia Type 2

The symptoms of NICCD are milder and present in children under one year of age as transient intrahepatic cholestasis, hypoproteinemia, growth retardation, hypoglycemia, fatty [genedx.com]

NICCD is characterized by suppression of the bile flow, hepatic fibrosis, low birth weight, growth retardation, hypoproteinemia, variable liver dysfunction. [slc.bioparadigms.org]

Younger Sib Total Protein/ Albumin Sep 08: Total Protein/ Albumin Jan 09: Total Protein/ Albumin April 09: Total Protein/ Albumin Jan 12: Unexplained Hypoproteinemia! [slideshare.net]

Congenital Enteropathy due to Enteropeptidase Deficiency

[…] definition Congenital enteropathy due to enteropeptidase deficiency is a rare, genetic, gastroenterological disease characterized by early-onset failure to thrive, edema, hypoproteinemia [orpha.net]

226200 Human phenotypes related to Enterokinase Deficiency: 32 # Description HPO Frequency HPO Source Accession 1 failure to thrive 32 HP:0001508 2 diarrhea 32 HP:0002014 3 hypoproteinemia [malacards.org]

Edema and even ascites may reflect hypoproteinemia associated with protein losing enteropathy caused by lymphatic obstruction or extensive mucosal inflammation. [en.wikipedia.org]

Nephrotic Syndrome

The substantial loss of protein in the urine results in complications such as hypoproteinemia; generalized edema; hypertension; and hyperlipidemias. [icd9data.com]

While in the hospital, she presented with hypoproteinemia and heavy proteinuria, meeting the diagnostic criteria of nephrotic syndrome. [ncbi.nlm.nih.gov]

The nephrotic syndrome is a distinct abnormal clinical and biochemical entity characterized by edema, massive proteinuria, hypoalbuminemia and hypoproteinemia, and hyperlipemia [jamanetwork.com]

Hypoalbuminemia

We present the case of an elderly patient with severe hypoproteinemia and important hypoalbuminemia associated with congestive heart failure and aggravation of tricuspid regurgitation [ncbi.nlm.nih.gov]

It is a type of hypoproteinemia. Albumin is a major protein in the human body, making up about 55 to 60% of total human plasma protein by mass. [en.wikipedia.org]

[…] effect of hypoalbuminemia on survival. [1] These beliefs have been challenged recently by advanced statistical techniques showing that hypoalbuminemia (or more broadly, hypoproteinemia [medscape.com]

Celiac Disease with Diffuse Intestinal Ulceration

[…] involvement is common • Associated with malabsorption Imaging • Marked thickening of the valvulae (picket-fence) • No dilatation or dilution • Affects entire small bowel Hypoproteinemia [learningradiology.com]

Lymphocytic Gastritis

Laboratory tests revealed severe hypoproteinemia. [ncbi.nlm.nih.gov]

Both patients had markedly enlarged gastric folds and serum hypoproteinemia, which were clinically suggestive of Ménétrier's disease. [ncbi.nlm.nih.gov]

For this reason we report the case of a 48-yr-old female with HLG, hypoproteinemia, and H. pylori infection whose disease resolved clinically, endoscopically, and pathologically [ncbi.nlm.nih.gov]

Orbital Infection

Hypoproteinemia and congestive heart failure cause eyelid swelling due to local edema. [pedsinreview.aappublications.org]

Zinc-Responsive Necrolytic Acral Erythema

Laboratory investigations revealed hypoproteinemia, hypoalbuminemia and proteinuria with normal renal parameters and negative hepatitis B/ C serology. [bioline.org.br]

Figure 1: Well demarcated, symmetrical, hyperpigmented, scaly plaques with erythematous rim over dorsum of feet Click here to view Laboratory investigations revealed hypoproteinemia [ijdvl.com]

Congenital Chylothorax

However, this is associated with morbidities such as infections, hypoproteinemia and thrombosis. [indianpediatrics.net]

Sequestration of the lymphatic fluid in the pleural cavities can lead to metabolic disorders: hypoproteinemia, meta-ololic acidosis, water, electrolyte and immune disorders [iliveok.com]

Hydrops may develop due to impaired venous return by cardiac and vena caval compression, and/or loss of protein into pleural space leading to generalized hypoproteinemia and [indianpediatrics.net]

Non-Immune Hydrops Fetalis

In addition, not all infants with hypoproteinemia become hydropic, and hydrops fetalis is uncommon in congenital nephrotic syndrome and congenital analbuminemia. [jpnim.com]

If hypoproteinemia develops further, relative decrease of protein would be higher than the decrease in plasma interstitium. [tibbiyardim.com]

Primary mechanisms that have been proposed include hypoproteinemia, myocardial failure, and lymphatic obstruction. [radiologykey.com]

Thoracic Duct Fistula

[…] lesion occurs in the thorax, typically during esophagectomy, cervical lesions also have associated postoperative morbidity, including nutritional complications (malnutrition, hypoproteinemia [elsevier.es]

 Hypoproteinemia  Hyponatremia  Hypochloremia  Dehydration  Emaciation  Lymphocytopenia and immunosupression  Pleural effusion - chylothorax  Wound problems - infection [slideshare.net]

Chronic lymph leak can also lead to immunosuppresion, hypoproteinemia and malnutrition [ 3 ]. [cardiothoracicsurgery.biomedcentral.com]

Intestinal Strongyloidiasis

This "hyperinfection" strongyloidiasis may cause malabsorption and hypoproteinemia with anasarca, and may be severe enough to kill the patient. [histopathology-india.net]

After confirming the cause for hypoproteinemia is GI tract, the etiology for this syndrome should be evaluated. [jdeonline.in]

Biochemical investigations showed hypoproteinemia (55.4 g/L, Normal = 66 to 87 g/L), hypoalbuminemia (15.8 g/l, Normal = 35 to 50 g/L) and hyponatremia (123 mmol/L, Normal [omjournal.org]

Corticosteroid-Binding-Globulin - Deficiency

Decreased levels of CBG are observed in women with polycystic ovary syndrome, hypoproteinemia, Cushing´s syndrome or corticoid treatment and some cases of vitamin B12 deficiency [biovendor.com]

Decreased levels of transcortin are observed in several conditions : hypoproteinemia, Cushing's syndrome or corticoïd treatment and in some cases of vitamin B12 deficiency [ibl-international.com]

Intestinal Capillariasis

Capillaria philippinensis, large populations of which are built up by internal autoinfection in the intestinal mucosa; characterized by abdominal pain, edema, diarrhea, cachexia, hypoproteinemia [medical-dictionary.thefreedictionary.com]

[…] philippinensis, large number of population built up by internal autoinfection in the intestinal mucosa; characterized by abdominal diarrhea, pain, hypotension, edema, cachexia, hypoproteinemia [omicsonline.org]

Chronic Pulmonary Edema

Postoperative pulmonary edema Pregnancy induced hypertension with pulmonary edema Pulmonary congestion Pulmonary congestion and hypostasis Pulmonary edema Pulmonary edema due to hypoproteinemia [healthprovidersdata.com]

적응증 1) 생략 2) 화상(Burns) 3) ~ 5) 생략 6) 급성 신증(Acute nephrosis) < 신 설 > 7) 아급성 또는 만성 저단백혈증(Subacute or chronic hypoproteinemia)(만성신질환, 만성간질환 등)로 인해 발생한 급성 합병증의 치료 ※ 급성합병증의 [kasl.org]

IV albumin may be indicated when hypoproteinemia contributes to pulmonary edema. Activity. [tele.med.ru]

Renal Glomerular Disease

[…] urine and blood testing include: Albuminuria, which causes the urine to foam Hematuria, which is the presence of blood in the urine and is responsible for the discoloration Hypoproteinemia [news-medical.net]

[…] urine" Edema - fluid retention in the legs, feet, hands, face, and abdomen High cholesterol Low blood albumin Inefficient filtration of waste from the blood Hypertension Hypoproteinemia [pennmedicine.org]

 Hypoproteinemia: low concentration of proteins in the blood Top of Page Causes A variety of diseases can result in glomerular disease. [kidneyhealthcare.com]

Hereditary Hypercarotenemia and Vitamin A Deficiency

[…] methylglutaconic aciduria 1 (MGA1) [MIM: 250950 ] AVP P01185 non-pleiotropic Diabetes insipidus, neurohypophyseal (NDI) [MIM: 125700 ] B2M P61769 non-pleiotropic Hypercatabolic hypoproteinemia [sbg.bio.ic.ac.uk]

Hypotension E34.8 Hypopinealism E23.0 Hypopituitarism (juvenile)- Hypoplasia, hypoplastic- E87.6 Hypopotassemia D68.2 Hypoproconvertinemia, congenital (hereditary) E77.8 Hypoproteinemia [coding-pro.com]

[…] neurohypophyseal) AVPR2 (Diabetes insipidus, nephrogenic) AVSD1 (Atrioventricular canal defect) AXIN1 (Caudal duplication anomaly) AXIN2 (Oligodontia-colorectal cancer syndrome) B2M (Hypoproteinemia [en.praenatal-medizin.de]

Charcot-Marie-Tooth Disease Type 1 with Aplasia Cutis Congenita

described in only two brothers to date (one of which died at 2 months of age), characterized by aplasia cutis congenita of the vertex and generalized edema (as well as hypoproteinemia [wordscope.com]

Congenital Disorder of Glycosylation Type 1L

[…] previously undescribed form of congenital disorder of glycosylation with variable presentation in siblings: early fetal loss with hydrops fetalis, and infant death with hypoproteinemia [ncbi.nlm.nih.gov]

Johanson-Blizzard Syndrome

Side effects of malnutrition, particularly hypoproteinemia, may lead to modified drug distribution, and infections. [accessanesthesiology.mhmedical.com]

Prognosis Pancreatic insufficiency and complications of severe malnutrition (e.g. severe hypoproteinemia, vitamin deficiency, immunodeficiency) may lead to death in infancy [orpha.net]

Discussion The most common complication of JBS is malabsorbtion syndrome due to exocrine pancreatic insufficiency, which may lead to chronic diarrhoea, anaemia, hypoproteinemia [tropicalgastro.com]

Congenital Disorder of Glycosylation Type 1J

Pascale De Lonlay Sandrine Dubois Vassili Valayannopoulos Eliane Depondt Chris Ottolenghi Daniel Rabier Résumé Les anomalies congénitales de glycosylation ou CDG (Congenital Disorders of Glycosylation) forment une classe d’erreurs innées du métabolisme, affectant la synthèse des glycannes des glycoprotéines [1, 2]. La[…] [link.springer.com]