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508 Possible Causes for Hypoprothrombinemia, Progressive or Intermittent Jaundice

  • Cholestatic Jaundice

    (ie, progressive, intermittent, fluctuating) The presence of systemic symptoms (eg, fever, anorexia, weight loss) Symptoms of gastric stasis (eg, early satiety, vomiting,[emedicine.medscape.com] In hypoprothrombinemia …associated with a lack of vitamin K, which is necessary for the synthesis of prothrombin in the liver cells.[britannica.com] History of fever, biliary colic and intermittent jaundice may be suggestive of cholangitis/choledocholithiasis.[ptolemy.ca]

  • Portal Cirrhosis

    Laennec's cirrhosis, also known as portal cirrhosis, alcoholic cirrhosis, fatty cirrhosis, or atrophic cirrhosis, [1] is named after René Laennec, [2] a French physician and the inventor of the stethoscope. It is a disease of the liver in which the normal lobular architecture is lost, with fibrosis (scarring) and later[…][en.wikipedia.org]

    Missing: Progressive or Intermittent Jaundice
  • Celiac Disease

    Celiac disease and hypoprothrombinemia. Nutrition 1999 ; 15 : 389 –391. Lubel JS, Burrell LM, Levidiotis V. An unexpected cause of macroscopic haematuria.[bloodjournal.org]

    Missing: Progressive or Intermittent Jaundice
  • Macronodular Cirrhosis

    Hepatocellular carcinoma is rare in infancy. This report describes the first documented case of congenital hepatocellular carcinoma associated with macronodular cirrhosis.[ncbi.nlm.nih.gov]

    Missing: Progressive or Intermittent Jaundice
  • Malabsorption Syndrome

    Purpura, subconjunctival hemorrhage, or even frank bleeding may reflect hypoprothrombinemia secondary to vitamin K malabsorption.[en.wikipedia.org] .  Bleeding disorders  Bleeding usually is a consequence of vitamin K malabsorption and subsequent hypoprothrombinemia.  Ecchymosis usually is the manifesting symptom,[slideshare.net]

    Missing: Progressive or Intermittent Jaundice
  • Primary Biliary Cirrhosis

    Petechiae, epistaxis, or hemorrhage resulting from hypoprothrombinemia may also be evident.[medical-dictionary.thefreedictionary.com]

    Missing: Progressive or Intermittent Jaundice
  • Acute Liver Failure

    Auxiliary partial orthotopic liver transplantation (APOLT) in acute liver failure acts as a bridge to native liver regeneration with potential for immunosuppression free survival. While technical concerns limit its universal acceptance, the indications in acute liver failure also need to be examined for this procedure to[…][ncbi.nlm.nih.gov]

    Missing: Progressive or Intermittent Jaundice
  • Liver Disease

    Anstee QM, Jones DEJ. Liver and biliary tract disease. In: Walker BR, Colledge NR, Ralston SH, Penman ID, eds. Davidson's Principles and Practice of Medicine. 22nd ed. Philadelphia, PA: Elsevier; 2014:chap 23. Martin P. Approach to the patient with liver disease. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 25th[…][nlm.nih.gov]

    Missing: Progressive or Intermittent Jaundice
  • Amyloidosis

    Intern Med. 2017;56(4):419-423. doi: 10.2169/internalmedicine.56.7548. Epub 2017 Feb 15. Author information 1 Department of Internal Medicine, Teikyo University School of Medicine, Japan. Abstract We report a 70-year-old woman with Sjögren's syndrome who had severe renal dysfunction with mild proteinuria and elevated[…][ncbi.nlm.nih.gov]

    Missing: Progressive or Intermittent Jaundice
  • Systemic Amyloidosis

    Persistent pleural effusions (PPE) occur in 1-2% of cases of systemic amyloidosis and have been postulated to result from direct disruption of the pleura by amyloid deposits. Patients are typically treated with percutaneous pleural drainage techniques. Pleural biopsies, done most commonly via percutaneous[…][ncbi.nlm.nih.gov]

    Missing: Progressive or Intermittent Jaundice

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