Hypotension & Paroxysmal Sweating & Spasticity - Hyperreflexia: Causes & Reasons

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Patient File

Sex unknown, Age unknown

Reported Symptoms

Hypotension, Paroxysmal Sweating, Spasticity - Hyperreflexia,

Negated

None

Unsure

None

Possible Causes

Aromatic L-Amino Acid Decarboxylase Deficiency

[…] clinical features suggesting spasticity. [jn.nutrition.org]

[…] aromatic L-amino acid decarboxylase deficiency who developed serious cardiac rhythm disturbances during treatment with intravenous dopamine and norepinephrine for severe hypotension [ncbi.nlm.nih.gov]

[…] defect in alpha-adrenergic activity is thought to play a key pathological role. 6 7 The autonomic features present in our patient (bilateral ptosis, and protracted periods of hypotension [hkmj.org]

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Spinal Shock

PHASE 4- SPASTICITY/HYPERREFLEXIA (1-12 MONTHS) CLINICAL DESCRIPTION-  DPR disappear in majority cases.  Cutaneous reflexes, DTRs and Babinski sign become hyperactive and [slideshare.net]

Despite this, hypotension persisted and the heart rate remained between 60 and 70 BPM. [wjgnet.com]

Spinal cord injury that is followed by sudden paroxysmal hypertension (acute onset of severe high blood pressure) requires immediate medical attention, especially where the [stenosisspinal.org]

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Autonomic Dysreflexia

When the stage of spinal shock passes, the typical UMN picture within hyperreflexia and spastic paralysis below the level of the injury supervenes. [casemed.case.edu]

Treatment of orthostatic hypotension with fludrocortisone acetate relieved these symptoms. [ncbi.nlm.nih.gov]

Acute autonomic dysreflexia is characterised by severe paroxysmal hypertension associated with throbbing headaches, profuse sweating, nasal stuffiness, flushing of the skin [ncbi.nlm.nih.gov]

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Autosomal Recessive Primary Microcephaly Type 10

Related symptoms: Autosomal recessive inheritance Generalized hypotonia Nystagmus Spasticity Hyperreflexia SOURCES: MESH GARD UMLS OMIM MONDO More info about AICARDI-GOUTIERES [mendelian.co]

KIF3A TRP53 Hypertrophy ANGPT1 EDN1 Osteochondrodysplasias DLL3 VEGFA Left Ventricular Hypertrophy EDN1 MYC Abnormalities, Multiple CTNNB1 FGFR2 Cecal Neoplasms CTNNB1 TRP53 Hypotension [selfdecode.com]

SCNN1A G:600228 Bell renal Bronchiectasis with or without elevated sweat chloride 2, 613021 (3) SCNN1A G:600228 Bell renal Pseudohypoaldosteronism, type I, 264350 (3) SCNN1B [usegalaxy.org]

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Extrapyramidal Disorder

Patients will complain of distal paresthesias and weakness of the extremities followed by spastic paresis and ataxia. [forums.studentdoctor.net]

Symptomatic treatment From the third year its efficacy declines 52.  Peripheral: • GIT: Nausea & Vomiting • CVS: Orthostatic hypotension, Dysrhythmias • Blood dyscrasias [slideshare.net]

This Syndrome potentially fatal reaction is characterized by "lead pipe rigidity," high fever, dehydration, sweating, elevated blood pressure, fast heart rate and respiration [medicalnewstoday.com]

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Occipital Lobe Tumor

hyperreflexia/ extensor plantar response (upgoing toe) vacuolar myelopathy vacuolation of myelin in the posterior and lateral columns of the primarily thoracic spinal cord [strokecenter.org]

Late signs of VAE include hypotension, arrhythmias, cyanosis, and mill wheel murmurs – VAE incidence is 25% in sitting position. [openanesthesia.org]

Paroxysmal attacks of intense fear associated with a range of somatic symptoms, such as palpitations, sweating, dyspnoea, and hyperventilation, are characteristic of panic [jnnp.bmj.com]

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Hepatic Encephalopathy

Hepatic myelopathy [54] is characterized by a progressive spastic paraparesis accompanied by hyperreflexia and extensor plantar responses. [hindawi.com]

[…] protein Portosystemic shunt (iatrogenic and spontaneous) Impaired toxin clearance Dehydration due to excessive fluid restriction, excessive diuresis or paracentesis, diarrhea Hypotension [cancertherapyadvisor.com]

Shortness of breath can manifest as orthopnea and/or paroxysmal nocturnal dyspnea. [ncbi.nlm.nih.gov]

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Cerebral Palsy

Spastic features included hypertonicity, hyperreflexia, and extensor plantar responses. Two older sibs had contractures. [ncbi.nlm.nih.gov]

[…] such as intraventricular haemorrhage, periventricular leukomalacia and hydrocephalus), strokes or seizures, cardiovascular disorders (such as patent ductus arteriosus and hypotension [doi.org]

Features that suggest autonomic dysfunction include altered heart rate and body temperature; pale skin or flushing of the skin; retching, vomiting, and abdominal pain; sweating [doi.org]

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Disorder of Catecholamine Synthesis

[…] clinical features suggesting spasticity. [jn.nutrition.org]

Symptoms from orthostatic hypotension become worse in late adolescence and in early adulthood. [medicinenet.com]

During the first hospital days the patient experienced repeated episodes of paroxysmal hypertension with headaches, sweating, palpitations and anxiety (without clinically [hormones.gr]

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Arnold Stickler Bourne Syndrome

Hyperreflexia Babinski's N/A Both upper and lower motor neuron signs Clinical diagnosis Normal Nonspecific findings of chronic denervation with reinnervation Neuropathic [wikidoc.org]

She does not secure paroxysmal symptoms of sweating, palpitations and anxiety to suggest a phaeochromocy- toma. buy 100mcg fluticasone with visa buy toradol without a prescription [chesapeakehumane.org]

History of tuberculosis History of malignancy History of other autoimmune disease Hypotension Hyperpigmentation Auricular cartilage calcification Vitiligo Electrolyte abnormalities [wikidoc.org]

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Ophthalmoplegia totalis with Ptosis and Miosis

[…] hemianopia Dyskinesia Red-green dyschromatopsia Dysphagia Abnormal pyramidal sign Retinopathy Tremor Hyperreflexia Abnormality of extrapyramidal motor function Motor delay [mendelian.co]

1; ORTHYP1 OMIM:618182 Orthostatic Hypotension 2; ORTHYP2 OMIM:143850 Orthostatic Hypotensive Disorder, Streeten Type OMIM:604715 Orthostatic Intolerance OMIM:112910 Osebold-Remondini [informatics.jax.org]

[…] of forehead Pallor or flushing Nausea Bradycardia Other Cluster Variants  Chronic paroxysmal hemicrania  Multiple short, severe HA occurring daily  Short episodes of cluster [studyres.com]

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Autosomal Dominant Mental Retardation Type 5

Spasticity in affected limbs Extensor plantar responses The striatal toe Myoclonic jerks Oculogyric crises Bilateral ptosis Mental retardation (intellectual disability) Autonomic [findzebra.com]

hypotension profoundly limits their activities. [massgeneral.org]

Patients with this condition may also have autonomic dysfunction such as pupillary abnormalities, abnormal reaction to intradermal histamine, abnormal sweating and orthostatic hypotension [reviewofophthalmology.com]

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