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28 Possible Causes for Hypothyroidism, Skeletal Dysplasia, Wide Space Between the First and Second Toe

  • Down Syndrome

    Among the subclinical hypothyroidism group, 25 (73.5%) had transient hypothyroidism and 9 (26.5%) persistent hypothyroidism.[ncbi.nlm.nih.gov] Dysplasia Society, Southeastern Regional Genetics Group Disclosure: Nothing to disclose.[emedicine.com] A wide space, often with a deep fissure between the first and second toes, is also common.[dx.doi.org]

  • Atelosteogenesis Type 2

    XY complete gonadal dysgenesis 46,XY partial gonadal dysgenesis Athyreosis Familial gestational hyperthyroidism Familial hyperthyroidism due to mutations in TSH receptor Hypothyroidism[csbg.cnb.csic.es] Thanatophoric dysplasia and achondrogenesis account for 62% of all lethal skeletal dysplasias. Achondroplasia is the most common nonlethal skeletal dysplasia.[thehealthscience.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Seckel Syndrome

    Based on the clinical and radiological features showing evidence of skeletal dysplasia, the diagnosis was revised to Majewski osteodysplastic primordial dwarfism type II ([ncbi.nlm.nih.gov] Synonym: pituitary dwarf. (05 Mar 2000) hypothyroid dwarf Dwarfism associated with lack of thyroid function. (05 Mar 2000) oil of dwarf pine needles Volatile oil from the[kmle.co.kr] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Russell-Silver Syndrome

    Human Growth Hormone (HGH) Deficiency, Cushing's Syndrome (Cortisol, Stress, Hormone Excess), Hypothyroidism, Nutritional Short Stature, Intrauterine Growth Retardation ("[lpamrs.memberclicks.net] A new skeletal dysplasia syndrome with rhizomelia of the humeri and other malformations. Clin Genet. 1986 Jan; 29 (1):83–87. [ PubMed ] [ Google Scholar ] Adeyokunnu AA.[ncbi.nlm.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Greenberg Dysplasia

    Greenberg skeletal dysplasia is a very rare, autosomal recessive, in utero, lethal chondrodystrophy for which only eight index cases of diverse ethnic origin have been reported[ncbi.nlm.nih.gov] . - ... hypothyroidism ... - achondroplasia ... - Noonan syndrome ... There may be other causes of short stature ...[ibis-birthdefects.org] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Atelosteogenesis

    This could be a unique skeletal dysplasia or the most severe end of the atelosteogenesis spectrum.[ncbi.nlm.nih.gov] XY complete gonadal dysgenesis 46,XY partial gonadal dysgenesis Athyreosis Familial gestational hyperthyroidism Familial hyperthyroidism due to mutations in TSH receptor Hypothyroidism[csbg.cnb.csic.es] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Dubowitz Syndrome

    There can be many associated heath problems including hypothyroidism (an underactive thyroid), heart defects, hypotonia and eye problems.[bertsbigadventure.org] 22q11.2 deletion syndrome Thanatophoric dysplasia type 2 Familial partial lipodystrophy Renal dysplasia, retinal pigmentary dystrophy, cerebellar ataxia and skeletal dysplasia[checkrare.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Kenny-Caffey Syndrome Type 1

    The following complications may develop in individuals affected by Kenny-Caffey Syndrome Type 1: Dwarfism Secondary hypothyroidism, which can lead to nervousness, muscle cramps[dovemed.com] Hereditary skeletal dysplasia resulting in proportionate dwarfism characterized by thickening of the inner corticalis and stenosis of the medullary cavities of the tubular[accessanesthesiology.mhmedical.com] space between the first and second toes.[medcraveonline.com]

  • Kleiner Holmes Syndrome

    Skeletal dysplasias. In: McAteer M, editor. Taybi and Lachman's radiology of syndromes, metabolic disorders, and skeletal dysplasias. 5 th ed.[ijri.org] Maternal antenatal history was uneventful except for subclinical hypothyroidism detected during gestation.[docksci.com] […] gap between first and second toes Wide space between 1st, 2nd toes Wide space between first and second toes Widely spaced 1st-2nd toes Widely spaced first and second toes[rarediseases.info.nih.gov]

  • Familial Congenital Nasolacrimal Duct Obstruction

    Thyroid Problems What is hypothyroidism? What causes hypothyroidism? Who gets hypothyroidism? How does hypothyroidism cause disease? What are the common findings?[calvarypediatrics.com] MICROPHTHALMIA/COLOBOMA AND SKELETAL DYSPLASIA SYNDROME; MCSKS Is also known as microphthalmia or coloboma with or without rhizomelic skeletal dysplasia, microphthalmia, syndromic[mendelian.co] space between first and second toes (sandal toes) clinodactyly of the fifth finger All of these are found in individuals without DS.[medicalhomeportal.org]

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