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30 Possible Causes for Hypothyroidism, Small Hand, Wide Space Between the First and Second Toe

  • Down Syndrome

    Among the subclinical hypothyroidism group, 25 (73.5%) had transient hypothyroidism and 9 (26.5%) persistent hypothyroidism.[ncbi.nlm.nih.gov] […] nasal bridge, slightly smaller ears, small mouth, decreased muscle tone, loose ligaments, and small hands and feet.[thearc.org] A wide space, often with a deep fissure between the first and second toes, is also common.[dx.doi.org]

  • Kenny-Caffey Syndrome Type 1

    The following complications may develop in individuals affected by Kenny-Caffey Syndrome Type 1: Dwarfism Secondary hypothyroidism, which can lead to nervousness, muscle cramps[dovemed.com] hands and feet, hypocalcaemia, hypoparathyroidism, radiologic evidence of cortical thickening of long bones with medullary stenosis, and absent diploic space in the skull[medical-dictionary.thefreedictionary.com] space between the first and second toes.[medcraveonline.com]

  • Dubowitz Syndrome

    There can be many associated heath problems including hypothyroidism (an underactive thyroid), heart defects, hypotonia and eye problems.[bertsbigadventure.org] […] feet [ more ] 0001773 Sloping forehead Inclined forehead Receding forehead [ more ] 0000340 Small hand Disproportionately small hands 0200055 Sparse lateral eyebrow Limited[rarediseases.info.nih.gov] In older patients, endocrine problems were common: hypogonadism, hypothyroidism, amenorrhea, and diabetes ( Table S5 ).[journals.plos.org]

  • Atelosteogenesis Type 2

    XY complete gonadal dysgenesis 46,XY partial gonadal dysgenesis Athyreosis Familial gestational hyperthyroidism Familial hyperthyroidism due to mutations in TSH receptor Hypothyroidism[csbg.cnb.csic.es] Note moderate short stature, flat facial profile (fetal face–like appearance), short forearms, and small hands.[thehealthscience.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Ring Chromosome 10

    […] hypospadia, bifid scrotum, bilateral cryptorchidism, bilateral inguinal hernia, vesico-uretheral reflux (grade III), recurrent pulmonary and urinary infections, subclinical hypothyroidism[biomedsearch.com] During this process, cropenis, cryptorchidism, hypertelorism, epicanthic some of the genetic materials may be lost and fold, microgenathia and small hands (7).[docksci.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Short Stature due to Endocrine Disorder

    […] insulin-like growth factor type 1 deficiency Growth hormone insensitivity syndrome Laron syndrome Laron syndrome with immunodeficiency MULIBREY nanism Parastremmatic dwarfism Rare hypothyroidism[se-atlas.de] […] feet [ more ] 0001773 Small hand Disproportionately small hands 0200055 Strabismus Cross-eyed Squint Squint eyes [ more ] 0000486 Synophrys Monobrow Unibrow [ more ] 0000664[rarediseases.info.nih.gov] This insensitivity may be primary (genetic) or secondary to conditions such as malnutrition, hypothyroidism, sex hormone deficiency, and chronic diseases.[labtestsonline.org]

  • Kleiner Holmes Syndrome

    Maternal antenatal history was uneventful except for subclinical hypothyroidism detected during gestation.[docksci.com] […] and Cerebellar Atrophy Growth Mental Deficiency Syndrome of Myhre GROWTH RETARDATION, INTELLECTUAL DEVELOPMENTAL DISORDER, HYPOTONIA, AND HEPATOPATHY Growth Retardation, Small[rgd.mcw.edu] […] gap between first and second toes Wide space between 1st, 2nd toes Wide space between first and second toes Widely spaced 1st-2nd toes Widely spaced first and second toes[rarediseases.info.nih.gov]

  • Familial Congenital Nasolacrimal Duct Obstruction

    Thyroid Problems What is hypothyroidism? What causes hypothyroidism? Who gets hypothyroidism? How does hypothyroidism cause disease? What are the common findings?[calvarypediatrics.com] […] and Puffy Hands and Feet, and Eczema OMIM:601138 Guanylate Cyclase 2e, Pseudogene; GUCY2EP OMIM:139290 Guanylate Kinase 3; GUK3 OMIM:139393 Guillain-Barre Syndrome, Familial[informatics.jax.org] space between first and second toes (sandal toes) clinodactyly of the fifth finger All of these are found in individuals without DS.[medicalhomeportal.org]

  • Cutis Laxa

    We report a newborn with autosomal recessive form of congenital cutis laxa, who had congenital hypothyroidism owing to isolated thyrotropin deficiency.[ncbi.nlm.nih.gov] […] nails, and large hands and feet with deep creases on the palms and soles (fig 11 ).[jmg.bmj.com] Other reported osteoarticular features are: a wide space between the first and second toes; talipes equinovarus; metatarsus adductus; genu recurvatum or genu valgum; flat[scielo.br]

  • Russell-Silver Syndrome

    Human Growth Hormone (HGH) Deficiency, Cushing's Syndrome (Cortisol, Stress, Hormone Excess), Hypothyroidism, Nutritional Short Stature, Intrauterine Growth Retardation ("[lpamrs.memberclicks.net] We report a small series of patients presenting with a range of hand anomalies, some of which have not been previously reported in association with this condition.[ncbi.nlm.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

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