IgA Decreased: Causes & Reasons

Possible Causes for IgA Decreased

A 20-year health follow-up study of 159 initially healthy blood donors with a severe deficiency of serum IgA ( < 0.05 x 10(-3) g/L) and of 45 donors with decreased serum IgA [ncbi.nlm.nih.gov]

What is IgA deficiency? Selective IgA Deficiency is decreased or absent IgA immunoglobulins in the blood serum and secretions. [patientslikeme.com]

Abstract A 20-year health follow-up study of 159 initially healthy blood donors with a severe deficiency of serum IgA ( −3 g/L) and of 45 donors with decreased serum IgA [doi.org]

Common Variable Immunodeficiency

(ii) decreased IgG, 105/502 cases (21%); (iii) decreased IgA, 131/502 cases (26%). [library.ehaweb.org]

[…] lymphocytes or plasma cells that are capable of producing antibodies frequent bacterial infections Serology The following serological abnormalities may be present: serum IgA [radiopaedia.org]

In some patients, there is a decrease in both IgG and IgA in the blood; in other patients, levels of all three major immunoglobulin types, IgG, IgA and IgM, may be decreased [piduk.org]

IgA Nephropathy

After supplement, urinary protein transiently increased, serum IgA circulating immune complexes decreased, and serum triglyceride and in-vitro platelet aggregation tended [ncbi.nlm.nih.gov]

IgA glomerulonephritis, as compared to a control group, were found. [ncbi.nlm.nih.gov]

[…] is in part directed by IgA, is decreased in patients with IgA nephropathy. 39 Mucosal T cells isolated from patients with IgA nephropathy show reduced expression of the genes [medical-journals.com]

Celiac Disease

Serum IgA tTG levels typically decrease as patients maintain a gluten-free diet. [ncbi.nlm.nih.gov]

IgG anti-tTG antibodies and EMA titres showed significant decreases (p<0.001) in treated patients. [ncbi.nlm.nih.gov]

During follow up with free diet the patient remained asymptomatic and all antibody titers decreased up to normalization. [ncbi.nlm.nih.gov]

Hyper-IgM Syndrome Type 3

[…] circulating IgA level 0002720 Decreased circulating IgG level 0004315 Decreased circulating total IgE 0005479 Immunodeficiency Decreased immune function 0002721 Impaired [rarediseases.info.nih.gov]

As a result, patients have decreased levels of immunoglobulin G (IgG) or IgA and normal to elevated levels of IgM in blood. [immunohic.com]

Due to this, people with this disease have decreased levels of IgA and IgG, yet average or elevated levels of IgM in their blood. [disabled-world.com]

Selective IgG Deficiency

The serum levels of IgG and IgA decreased progressively in the fourth decade of life, while serum IgM increased. [ncbi.nlm.nih.gov]

RESULTS: We found a significant decrease of IgG1 levels in the placebo group, which was particularly pronounced in females. [ghrnet.org]

For information on deficiencies of other immunoglobulin types, see the Medscape Reference articles IgA Deficiency, IgD Deficiency, and IgM Deficiency. [emedicine.medscape.com]

X-Linked Hyper-IgM Syndrome

IgA and IgG levels. [haematologica.org]

T cell activation Decreased circulating IgA level Decreased circulating IgE Decreased circulating IgG level Dysgammaglobulinemia Enlarged tonsils Immunodeficiency Impaired [ncbi.nlm.nih.gov]

With a median follow-up of 13 months (range, 4–144 months), 29/42 (69%) patients had decreased IgA levels at baseline, and 31/42 (74%) at the end of follow-up (P=0.63). [haematologica.org]

Complement Factor I Deficiency

[…] in number and function of T cells -B cells are decreased ( IgM, IgE and IgA are decreased with IgG usually normal) -X-linked recessive -Therapy includes platelet transfusions [quizlet.com]

IgA deficiency in saliva Decreased antibody response to immunizations Decreased neutrophil chemotaxis Nutritional Deficiencies Malabsorption can lead to zinc deficiency Anatomic [pedemmorsels.com]

Serum IgG, IgA, and IgM concentrations were elevated. The percentage of T-lymphocytes was decreased, but T-cell response to mitogens was normal. [cdc.gov]

Familial Cold Autoinflammatory Syndrome Type 3

2016, Número 3 Rev Cubana Hematol Inmunol Hemoter 2016; 32 (3) Sánchez SM, Marsán SV, Pino BD, Díaz DG, Macías AC Idioma: Español Referencias bibliográficas: 83 Paginas: 325-339 Archivo PDF: 121.97 Kb. RESUMEN Los desórdenes autoinflamatorios monogénicos comprenden un grupo de enfermedades caracterizadas por[…] [medigraphic.com]

Autoimmune Lymphoproliferative Syndrome Type 2B

Decreased circulating IgA level MedGen UID: 57934 •Concept ID: C0162538 • Disease or Syndrome Decreased levels of immunoglobulin A (IgA). [ncbi.nlm.nih.gov]

CD4:CD8 ratio Decreased circulating IgA level Decreased circulating IgG level Decreased circulating total IgM Decreased T cell activation Defective B cell activation Eczema [ncbi.nlm.nih.gov]

Decreased circulating total IgM MedGen UID: 116095 •Concept ID: C0239989 • Finding An abnormally decreased level of immunoglobulin M (IgM) in blood. [ncbi.nlm.nih.gov]

Hyper-IgM Syndrome Type 5

[from OMIM] Show allHide all Abnormality of the immune system Decreased circulating IgA level Decreased circulating IgG level Epididymitis Immunodeficiency Impaired Ig class [ncbi.nlm.nih.gov]

Decreased circulating IgA level MedGen UID: 57934 •Concept ID: C0162538 • Disease or Syndrome Decreased levels of immunoglobulin A (IgA). [ncbi.nlm.nih.gov]

The typical symptoms of the syndrome are: Impaired Ig class switch recombination, Immunodeficiency, Decreased circulating IgG level, Decreased circulating IgA level, Epididymitis [fdna.health]

Hyper-IgM Syndrome Type 2

Decreased circulating IgA level MedGen UID: 57934 •Concept ID: C0162538 • Disease or Syndrome Decreased levels of immunoglobulin A (IgA). [ncbi.nlm.nih.gov]

As a result, patients with this disease have decreased levels of IgG and IgA but normal or elevated levels of IgM in their blood. [primaryimmune.org]

IgG and IgA. [elsevier.es]

Okur-Chung Neurodevelopmental Syndrome

Decreased circulating IgA level MedGen UID: 57934 •Concept ID: C0162538 • Disease or Syndrome Decreased levels of immunoglobulin A (IgA). [ncbi.nlm.nih.gov]

[…] circulating antibody level Decreased circulating IgA level Decreased circulating IgG level Abnormality of the integument Synophrys Abnormality of the musculoskeletal system [ncbi.nlm.nih.gov]

Decreased circulating antibody level MedGen UID: 892481 •Concept ID: C4048270 • Finding An abnormally decreased level of immunoglobulin in blood. [ncbi.nlm.nih.gov]

Bruce-Winship Syndrome

Immunoglobulin A (IgA) deficiency (the most common immunodeficiency) is due to decreased or absent serum and intestinal IgA, which clinically appears similar to celiac disease [emedicine.medscape.com]

Hyper-IgM Syndrome

As a result, patients have decreased levels of immunoglobulin G (IgG) or IgA and normal to elevated levels of IgM in blood. [immunohic.com]

[…] pro-B cells Increased pre-B cells Decreased immunoglobulins of all classes Selective IgA Deficiency Stem cell defect (Transferrable with marrow transplant) Lack of IL-4, [wikidoc.org]

Because of the class switch recombination defect, patients with HIGM have decreased serum levels of IgG, IgA, and IgE, and elevated or normal levels of serum IgM.3 Signals [jamanetwork.com]

Transient Hypogammaglobulinemia of Infancy

IgM, IgA, and IgG response to pneumococcal vaccine in children with transient hypogammaglobulinemia of infancy. ( 26233927 ) Moschese V....Quinti I. 2015 6 Does intravenous [malacards.org]

CONSUMERS: Click here for the Consumer Version Transient hypogammaglobulinemia of infancy is a temporary decrease in serum IgG and sometimes IgA and other Ig isotypes to levels [merck.com]

[…] the genes encoding the TGF-I^ receptors. ( 23899993 ) Rutkowska M....Siedlar M. 2013 8 B-cell subsets in patients with transient hypogammaglobulinemia of infancy, partial IgA [malacards.org]

Immunodeficiency Type 37

Decreased serum immunoglobulin A (IgA) can be caused by various anticonvulsant3 and psychotropic agents, such as phenytoin, carbamazepine, valproic acid, chlorpromazine,4 [es.slideshare.net]

There are also reports of lamotrigine and carbamazepine causing decreases in total immunoglobulin G (IgG) and IgG subclasses5 and a common variable immunodeficiency–like disease [es.slideshare.net]

Hypogammaglobulinemia

(ii) decreased IgG, 105/502 cases (21%); (iii) decreased IgA, 131/502 cases (26%). [library.ehaweb.org]

Often, serum IgA levels are also decreased; however, IgM levels are typically within the reference range. [cancertherapyadvisor.com]

[…] and IgG levels decreased and were significantly lower than pretransplant levels; pre- and post-transplant IgA and pretransplant IgG levels were significantly lower in patients [ncbi.nlm.nih.gov]

Common Variable Immunodeficiency Type 4

In some patients, there is a decrease in both IgG and IgA; in others, all three major types of immunoglobulins (IgG, IgA and IgM) are decreased. [cvidawareness.org]

In some patients, there is a decrease in both IgG and IgA in the blood; in others, levels of all three major immunoglobulin types, IgG, IgA and IgM, may be decreased. [piduk.org]

The disorder is diagnosed after significantly decreased IgG and IgA levels are observed in the patient's blood. Some patients may also have decreased IgM levels. [medigoo.com]

Hyper-IgM Syndrome Type 4

As a result, patients have decreased levels of immunoglobulin G (IgG) or IgA and normal to elevated levels of IgM in blood. [immunohic.com]

As a consequence, people with HIGM have decreased concentrations of serum IgG and IgA and normal or elevated IgM, leading to increased susceptibility to infections. [owlapps.net]

Due to this, people with this disease have decreased levels of IgA and IgG, yet average or elevated levels of IgM in their blood. [disabled-world.com]

Autoimmune Lymphoproliferative Syndrome Type 3

[…] defects, spider angiomas, IgA deficiency Labs: decreased IgA Defect: XR defect -> progressive deletion of B and T cells Presentation: Triad (TIE) = Thrombocytopenic purpura [quizlet.com]

Lab: decreased IgG levels with increased IgA and IgM. [altmeyers.org]

and IgE; normal or decreased concentration of IgM Increased levels of interleukin (IL)-10 Increased levels of vitamin B12 Autoimmune antibodies Autoantibodies to red cells [basicmedicalkey.com]

Absent Thumb - Short Stature - Immunodeficiency Syndrome

[…] serum IgA Late onset of pulmonary fibrosis Increased alpha-fetoprotein Increased radiosensitivity Genetics[edit] This condition is due to mutations in the RNF168 gene. [en.wikipedia.org]

B cell defect-decreased IgA, normal other Ig -high frequency respiratory and gastrointestinal infections B cell defect-decreased IgG and IgA-high IgM -susceptible to encapsulated [brainscape.com]

IgG and IgA, increased alpha-fetoprotein (AFP), and late onset of pulmonary fibrosis. [link.springer.com]

Seckel-Like Syndrome Type Majoor-Krakauer

Serological testing will show decreased immunoglobulin levels (IgA, IgG, and IgE). CBC will show lymphopenia. [statpearls.com]

Investigations for AT should include CBC with lymphopenia; serological testing will show increased alpha-fetoprotein (the most consistent test in AT)[31] and decreased IgA [statpearls.com]

Isolated Agammaglobulinemia

Review Topic QID: 106685 1 Increased IgE; Decreased IgG, IgM 2 Decreased IgE, IgM, IgA, IgG 3 Increased IgE, IgA; Decreased IgM 5 Increased IgM; Decreased IgG, IgA, IgE M1 [medbullets.com]

[…] levels (however, the levels of IgG, IgM, and IgA may all be decreased in severe protein-losing enteropathy) Hypoalbuminemia (see Hypoalbuminemia, [[Hypoalbuminemia]]) Edema [mdnxs.com]

Normal numbers of B cells with decreased IgG and IgA and increased IgM : Hyper-IgM syndromes Normal numbers of B cells with isotype or light chain deficiencies: heavy chain [en.wikipedia.org]

Wiskott-Aldrich Syndrome

QID: 106655 Increased IgM; Decreased IgG, IgA, IgE Increased IgE, IgA; Decreased IgM Increased IgE; Decreased IgG, IgM, IgA Decreased IgE, IgM, IgA, IgG M 2 D Select Answer [step1.medbullets.com]

Review Topic QID: 106655 1 Increased IgM; Decreased IgG, IgA, IgE 3 Increased IgE, IgA; Decreased IgM 4 Increased IgE; Decreased IgG, IgM 5 Decreased IgE, IgM, IgA, IgG M1 [medbullets.com]

Laboratory measurements of serum immunoglobulins show increased IgE and IgA but decreased IgM. [step1.medbullets.com]

Roberts Syndrome

Immunological studies showed decreased levels of IgA, decreased number of CD3 positive T lymphocytes and decreased CD4 positive; they also showed cells with normal B quantification [medigraphic.com]

Dubowitz Syndrome

[…] circulating IgA level 0002720 Decreased circulating IgG level 0004315 Delayed speech and language development Deficiency of speech development Delayed language development [rarediseases.info.nih.gov]

Increased width of tip of nose Nasal tip, broad Nasal tip, wide Wide tip of nose [ more ] 0000455 Carious teeth Dental cavities Tooth cavities Tooth decay [ more ] 0000670 Decreased [rarediseases.info.nih.gov]

Autosomal Agammaglobulinemia

Anaphylaxis upon exposure to blood products containing IgA. failure to mature into plasma cells. decreased secretory IgA Ataxia-TelangiectasiaDefects in ATM gene, which codes [memorize.com]

Lab findings include decreased levels of IgG, IgM, and IgA. [medbullets.com]

Of the primary immunodeficiency disorders, selective IgA deficiency may have the highest incidence (one case per 300 to 700 persons, according to estimates based on blood [aafp.org]

LIG4 Syndrome

IgA, increased alpha-fetoprotein and late onset of pulmonary fibrosis. [bredagenetics.com]

Decreased IgA/IgM levels may be associated with early clinical digestive symptoms, similar to the disease selective IgA deficiency. [ncbi.nlm.nih.gov]

Other clinical signs of RIDDLE syndrome may include mild ataxia, microcephaly, normal intelligence, conjunctival telangiectasia, recurrent sinus infections, decreased serum [bredagenetics.com]

Immunodeficiency Type 31C

[…] disease, atopy, anaphylaxis to IgA containing products diagnostics of IgA deficiency decrease of IgA with normal IgG & IgM levels cause of common variable immunodeficiency [quizlet.com]

IgM Decreased number of plasma cells Flow cytometry shows normal B and T cell subsets Poor response to immunizations Treatment : References: [1] [2] [3] [4] [5] [6] [7] [amboss.com]

[…] deficiency diagnostics of ataxia-telangiectasia increased AFP decreased IgA, IgG, & IgE lymphopenia cerebellar atrophy cause of hyper-IgM syndrome most common due to defective [quizlet.com]