IgA Decreased: Causes & Reasons

Warning: Do not use in emergencies, if pregnant, if under 18, or as a substitute for a doctor’s advice or diagnosis. Learn more

Possible Causes for IgA Decreased

Selective IgA Immunodeficiency

A 20-year health follow-up study of 159 initially healthy blood donors with a severe deficiency of serum IgA ( < 0.05 x 10(-3) g/L) and of 45 donors with decreased serum IgA [ncbi.nlm.nih.gov]

What is IgA deficiency? Selective IgA Deficiency is decreased or absent IgA immunoglobulins in the blood serum and secretions. [patientslikeme.com]

Abstract A 20-year health follow-up study of 159 initially healthy blood donors with a severe deficiency of serum IgA ( −3 g/L) and of 45 donors with decreased serum IgA [doi.org]

Common Variable Immunodeficiency

(ii) decreased IgG, 105/502 cases (21%); (iii) decreased IgA, 131/502 cases (26%). [library.ehaweb.org]

[…] lymphocytes or plasma cells that are capable of producing antibodies frequent bacterial infections Serology The following serological abnormalities may be present: serum IgA [radiopaedia.org]

In some patients, there is a decrease in both IgG and IgA in the blood; in other patients, levels of all three major immunoglobulin types, IgG, IgA and IgM, may be decreased [piduk.org]

IgA Nephropathy

After supplement, urinary protein transiently increased, serum IgA circulating immune complexes decreased, and serum triglyceride and in-vitro platelet aggregation tended [ncbi.nlm.nih.gov]

IgA glomerulonephritis, as compared to a control group, were found. [ncbi.nlm.nih.gov]

[…] is in part directed by IgA, is decreased in patients with IgA nephropathy. 39 Mucosal T cells isolated from patients with IgA nephropathy show reduced expression of the genes [medical-journals.com]

Celiac Disease

Serum IgA tTG levels typically decrease as patients maintain a gluten-free diet. [ncbi.nlm.nih.gov]

IgG anti-tTG antibodies and EMA titres showed significant decreases (p<0.001) in treated patients. [ncbi.nlm.nih.gov]

During follow up with free diet the patient remained asymptomatic and all antibody titers decreased up to normalization. [ncbi.nlm.nih.gov]

Selective IgG Deficiency

The serum levels of IgG and IgA decreased progressively in the fourth decade of life, while serum IgM increased. [ncbi.nlm.nih.gov]

RESULTS: We found a significant decrease of IgG1 levels in the placebo group, which was particularly pronounced in females. [ghrnet.org]

For information on deficiencies of other immunoglobulin types, see the Medscape Reference articles IgA Deficiency, IgD Deficiency, and IgM Deficiency. [emedicine.medscape.com]

Hyper-IgM Syndrome Type 3

[…] circulating IgA level 0002720 Decreased circulating IgG level 0004315 Decreased circulating total IgE 0005479 Immunodeficiency Decreased immune function 0002721 Impaired [rarediseases.info.nih.gov]

As a result, patients have decreased levels of immunoglobulin G (IgG) or IgA and normal to elevated levels of IgM in blood. [immunohic.com]

As a consequence, people with HIGM have decreased concentrations of serum IgG and IgA and normal or elevated IgM, leading to increased susceptibility to infections.[8][7][ [en.wikipedia.org]

X-Linked Hyper-IgM Syndrome

IgA and IgG levels. [haematologica.org]

T cell activation Decreased circulating IgA level Decreased circulating IgE Decreased circulating IgG level Dysgammaglobulinemia Enlarged tonsils Immunodeficiency Impaired [ncbi.nlm.nih.gov]

With a median follow-up of 13 months (range, 4–144 months), 29/42 (69%) patients had decreased IgA levels at baseline, and 31/42 (74%) at the end of follow-up (P=0.63). [haematologica.org]

Familial Cold Autoinflammatory Syndrome Type 3

Complement Factor I Deficiency

[…] in number and function of T cells -B cells are decreased ( IgM, IgE and IgA are decreased with IgG usually normal) -X-linked recessive -Therapy includes platelet transfusions [quizlet.com]

IgA deficiency in saliva Decreased antibody response to immunizations Decreased neutrophil chemotaxis Nutritional Deficiencies Malabsorption can lead to zinc deficiency Anatomic [pedemmorsels.com]

Serum IgG, IgA, and IgM concentrations were elevated. The percentage of T-lymphocytes was decreased, but T-cell response to mitogens was normal. [cdc.gov]

Bruce-Winship Syndrome

Immunoglobulin A (IgA) deficiency (the most common immunodeficiency) is due to decreased or absent serum and intestinal IgA, which clinically appears similar to celiac disease [emedicine.medscape.com]

Transient Hypogammaglobulinemia of Infancy

IgM, IgA, and IgG response to pneumococcal vaccine in children with transient hypogammaglobulinemia of infancy. ( 26233927 ) Moschese V....Quinti I. 2015 6 Does intravenous [malacards.org]

CONSUMERS: Click here for the Consumer Version Transient hypogammaglobulinemia of infancy is a temporary decrease in serum IgG and sometimes IgA and other Ig isotypes to levels [merck.com]

[…] the genes encoding the TGF-I^ receptors. ( 23899993 ) Rutkowska M....Siedlar M. 2013 8 B-cell subsets in patients with transient hypogammaglobulinemia of infancy, partial IgA [malacards.org]

Hypogammaglobulinemia

(ii) decreased IgG, 105/502 cases (21%); (iii) decreased IgA, 131/502 cases (26%). [library.ehaweb.org]

[…] and IgG levels decreased and were significantly lower than pretransplant levels; pre- and post-transplant IgA and pretransplant IgG levels were significantly lower in patients [ncbi.nlm.nih.gov]

Often, serum IgA levels are also decreased; however, IgM levels are typically within the reference range. [clinicaladvisor.com]

Hyper-IgM Syndrome Type 4

As a result, patients have decreased levels of immunoglobulin G (IgG) or IgA and normal to elevated levels of IgM in blood. [immunohic.com]

As a consequence, people with HIGM have decreased concentrations of serum IgG and IgA and normal or elevated IgM, leading to increased susceptibility to infections. [owlapps.net]

As a consequence, people with HIGM have decreased concentrations of serum IgG and IgA and normal or elevated IgM, leading to increased susceptibility to infections.[8][7][ [en.wikipedia.org]

Common Variable Immunodeficiency Type 4

In some patients, there is a decrease in both IgG and IgA; in others, all three major types of immunoglobulins (IgG, IgA and IgM) are decreased. [cvidawareness.org]

In some patients, there is a decrease in both IgG and IgA in the blood; in others, levels of all three major immunoglobulin types, IgG, IgA and IgM, may be decreased. [piduk.org]

The disorder is diagnosed after significantly decreased IgG and IgA levels are observed in the patient's blood. Some patients may also have decreased IgM levels. [medigoo.com]

Adult Idiopathic Neutropenia

Ann Hematol. 2005 Oct;84(11):709-14. Epub 2005 Jun 29. Author information 1 Haematology and Hemotherapy Center, State University of Campinas, UNICAMP, Campinas, Sao Paulo, Brazil. maddas@unicamp.br Abstract Chronic idiopathic neutropenia of adults (CINA) is a granulocytic disorder characterised by the "unexplained"[…] [ncbi.nlm.nih.gov]

Hyper-IgM Syndrome Type 5

As a result, patients have decreased levels of immunoglobulin G (IgG) or IgA and normal to elevated levels of IgM in blood. [immunohic.com]

As a consequence, people with HIGM have decreased concentrations of serum IgG and IgA and normal or elevated IgM, leading to increased susceptibility to infections. [owlapps.net]

As a result, patients with this disease have decreased levels of IgG and IgA but normal or elevated levels of IgM in their blood. [primaryimmune.org]

Roberts Syndrome

Immunological studies showed decreased levels of IgA, decreased number of CD3 positive T lymphocytes and decreased CD4 positive; they also showed cells with normal B quantification [medigraphic.com]

Hyper-IgM Syndrome

As a result, patients have decreased levels of immunoglobulin G (IgG) or IgA and normal to elevated levels of IgM in blood. [immunohic.com]

Because of the class switch recombination defect, patients with HIGM have decreased serum levels of IgG, IgA, and IgE, and elevated or normal levels of serum IgM.3 Signals [jamanetwork.com]

[…] genes] Hyper-IgM syndrome (HIGM) is a type of primary antibody deficiency characterized by the inability of B cells to switch from being IgM producing cells to being IgG, IgA [immunohic.com]

Isolated Agammaglobulinemia

Review Topic QID: 106685 1 Increased IgE; Decreased IgG, IgM 2 Decreased IgE, IgM, IgA, IgG 3 Increased IgE, IgA; Decreased IgM 5 Increased IgM; Decreased IgG, IgA, IgE M1 [medbullets.com]

[…] levels (however, the levels of IgG, IgM, and IgA may all be decreased in severe protein-losing enteropathy) Hypoalbuminemia (see Hypoalbuminemia, [[Hypoalbuminemia]]) Edema [mdnxs.com]

Normal numbers of B cells with decreased IgG and IgA and increased IgM : Hyper-IgM syndromes Normal numbers of B cells with isotype or light chain deficiencies: heavy chain [en.wikipedia.org]

Autoimmune Lymphoproliferative Syndrome Type 3

[…] defects, spider angiomas, IgA deficiency Labs: decreased IgA Defect: XR defect -> progressive deletion of B and T cells Presentation: Triad (TIE) = Thrombocytopenic purpura [quizlet.com]

and IgE; normal or decreased concentration of IgM Increased levels of interleukin (IL)-10 Increased levels of vitamin B12 Autoimmune antibodies Autoantibodies to red cells [basicmedicalkey.com]

[…] allergies, diarrhea, anaphylaxis on exposure to blood products with Specific Ig Labs: decreased plasma cells, decreased secretory IgA Common Variable Immunodeficiency (CVID [quizlet.com]

Wiskott-Aldrich Syndrome

Review Topic | Tested Concept QID: 106655 1 Increased IgM; Decreased IgG, IgA, IgE 3 Increased IgE, IgA; Decreased IgM 4 Increased IgE; Decreased IgG, IgM, IgA 5 Decreased [step1.medbullets.com]

Review Topic QID: 106655 1 Increased IgM; Decreased IgG, IgA, IgE 3 Increased IgE, IgA; Decreased IgM 4 Increased IgE; Decreased IgG, IgM 5 Decreased IgE, IgM, IgA, IgG M1 [medbullets.com]

Laboratory measurements of serum immunoglobulins show increased IgE and IgA but decreased IgM. [step1.medbullets.com]

Dubowitz Syndrome

[…] circulating IgA level 0002720 Decreased circulating IgG level 0004315 Delayed speech and language development Deficiency of speech development Delayed language development [rarediseases.info.nih.gov]

Increased width of tip of nose Nasal tip, broad Nasal tip, wide Wide tip of nose [ more ] 0000455 Carious teeth Dental cavities Tooth cavities Tooth decay [ more ] 0000670 Decreased [rarediseases.info.nih.gov]

Autosomal Agammaglobulinemia

Anaphylaxis upon exposure to blood products containing IgA. failure to mature into plasma cells. decreased secretory IgA Ataxia-TelangiectasiaDefects in ATM gene, which codes [memorize.com]

Lab findings include decreased levels of IgG, IgM, and IgA. [medbullets.com]

Of the primary immunodeficiency disorders, selective IgA deficiency may have the highest incidence (one case per 300 to 700 persons, according to estimates based on blood [aafp.org]

Dysgammaglobulinemia

RESULTS: Total IgA was decreased in TS/OCD patients (median 115 mg/100 mL) compared with control subjects (141 mg/100 mL; p = .02). [ncbi.nlm.nih.gov]

IgG deficiency is often found in children as transient hypogammaglobulinemia of infancy (THI), which may occur with or without additional decreases in IgA or IgM. [howlingpixel.com]

Specific IgA against all antigens, except tubulin were also decreased in the patients (MPB 0 vs. 13 [ELISA units [EU]; myelin-associated glycoprotein 29 vs. 44 EU, p = .04 [ncbi.nlm.nih.gov]

Idiopathic Neutropenia

Quantification of serum and urine proteins gave serum IgG 4.94 g/L, IgA 1 ). Percentages of other bone marrow cells were decreased. [ncbi.nlm.nih.gov]

Immunodeficiency Type 31C

[…] disease, atopy, anaphylaxis to IgA containing products diagnostics of IgA deficiency decrease of IgA with normal IgG & IgM levels cause of common variable immunodeficiency [quizlet.com]

IgM Decreased number of plasma cells Flow cytometry shows normal B and T cell subsets Poor response to immunizations Treatment : References: [1] [2] [3] [4] [5] [6] [7] [amboss.com]

[…] deficiency diagnostics of ataxia-telangiectasia increased AFP decreased IgA, IgG, & IgE lymphopenia cerebellar atrophy cause of hyper-IgM syndrome most common due to defective [quizlet.com]

LIG4 Syndrome

IgA, increased alpha-fetoprotein and late onset of pulmonary fibrosis. [bredagenetics.com]

Decreased IgA/IgM levels may be associated with early clinical digestive symptoms, similar to the disease selective IgA deficiency. [ncbi.nlm.nih.gov]

Other clinical signs of RIDDLE syndrome may include mild ataxia, microcephaly, normal intelligence, conjunctival telangiectasia, recurrent sinus infections, decreased serum [bredagenetics.com]

Absent Thumb - Short Stature - Immunodeficiency Syndrome

B cell defect-decreased IgA, normal other Ig -high frequency respiratory and gastrointestinal infections B cell defect-decreased IgG and IgA-high IgM -susceptible to encapsulated [brainscape.com]

Intestinal Lymphoid Hyperplasia

In a small minority, immunodeficiencies underlie the hyperplastic state.2 Some patients have low or absent IgA and IgM levels, decreased IgG levels, susceptibility to infection [answers.yahoo.com]

All immunoglobulin classes were decreased (IgG 1.9g/l; IgM 0.23 g/l; IgA 0.009g/l). The examination of the bone marrow showed megaloblastosis. [latunisiemedicale.com]

Some patients have low or absent IgA and IgM levels, decreased IgG levels, susceptibility to infection, small intestine bacterial overgrowth, diarrhea with or without steatorrhea [bmcgastroenterol.biomedcentral.com]

Primary Immune Deficiency Disorder

In some patients, there is a decrease in both IgG and IgA; in others, all three major types of immunoglobulins (IgG, IgA and IgM) are decreased. [primaryimmune.org]

IgA deficiency is defined as decreased or absent levels of serum IgA with normal IgG and IgM levels in patients older than age 4 ( 3 3. [acphospitalist.org]

On further studies, the patient was found to have decreased serum levels of IgG, IgA, and IgM and an increased number of CD8 cells. [emedicine.medscape.com]