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455 Possible Causes for Immune Thrombocytopenic Purpura, Splenomegaly

  • Castleman Disease

    Older age ( 40 years), splenomegaly, and hypoalbuminemia were risk factors for poorer MCD prognosis.[ncbi.nlm.nih.gov] thrombocytopenic purpura (ITP). [4] Last updated: 6/25/2015 In about half of people with multicentric Castleman disease (MCD), it is caused by human herpesvirus-8 (HHV-8)[rarediseases.info.nih.gov] The disease is characterized by fever, weight loss, anemia, polyclonal hyperglobulinemia, splenomegaly, thrombocytosis and peripheral lymphadenopathy.[ncbi.nlm.nih.gov]

  • Infectious Mononucleosis

    Clinical estimates of splenomegaly are fallible.[ncbi.nlm.nih.gov] thrombocytopenic purpura, erythema nodosum or pedunculated papule on the tongue.[omicsonline.org] In adolescent and adult patients presenting with sore throat, the presence of posterior cervical, inguinal or axillary adenopathy, palatine petechiae, splenomegaly, or atypical[ncbi.nlm.nih.gov]

  • Hypersplenism

    While 38 patients displayed splenomegaly, 121 showed normal spleen volumes at 6 months after LDLT (LDLT).[ncbi.nlm.nih.gov] Splenectomy is one of the primary choices of treatment in immune thrombocytopenic purpura. However, the disease may relapse despite splenectomy.[ncbi.nlm.nih.gov] Some authors believe an overactive spleen without enlargement may be considered hypersplenism such as is seen in immune thrombocytopenic purpura and autoimmune hemolytic anemia[tipsdiscover.com]

  • Hereditary Spherocytosis

    Due to the membrane defect, there is increased fragility, hemolytic anemia, marked splenomegaly and hyperbilirubinemia.[ncbi.nlm.nih.gov] Evans' syndrome is a clinical syndrome characterized by autoimmune hemolytic anemia (AIHA) accompanied by immune thrombocytopenic purpura (ITP).[ncbi.nlm.nih.gov] Immune thrombocytopenic purpura (ITP) is a condition of having a low platelet count caused by autoimmune with antibodies against platelets.[jhoonline.biomedcentral.com]

  • Portal Vein Thrombosis

    She had splenomegaly and thrombocytopenia. Investigations did not reveal any prothrombotic disorder.[ncbi.nlm.nih.gov] The patient developed immune thrombocytopenic purpura (ITP) that was diagnosed on the basis of nasal bleeding, progressive severe thrombocytopenia, elevation of platelet-associated[ncbi.nlm.nih.gov] Computed tomography revealed splenomegaly, a mesenteric mass measuring 3.5 cm and intra-abdominal lymphadenopathies at the hepatic hilum.[ncbi.nlm.nih.gov]

  • Chronic Congestive Splenomegaly

    splenomegaly [ sple″no-meg ah-le ] enlargement of the spleen. congestive splenomegaly splenomegaly secondary to portal hypertension, with ascites, anemia, thrombocytopenia[medical-dictionary.thefreedictionary.com] Journal of Hematology & Oncology 2009 2 (Suppl 1) :A5 McMillan; licensee BioMed Central Ltd. 2009 Published: 26 June 2009 Keywords Thrombotic Thrombocytopenic Purpura Immune[jhoonline.biomedcentral.com] Senile spleen with ordinary hematoxylin-Eosin (H-E) stain showed no much difference from mild degree of splenomegaly.[jpatholtm.org]

  • Extramedullary Hematopoiesis

    These findings thus challenge our understanding of splenomegaly as a marker of disease.[ncbi.nlm.nih.gov] The phenomenon occurs in a number of disease states, notably in myelofibrosis, thalassemia, immune thrombocytopenic purpura, sickle cell anemia, polycythemia vera, and myelodysplastic[ncbi.nlm.nih.gov] The most common of these disorders include thalassemia, hereditary spherocytosis, sickle cell anemia, congenital dyserythroblastic anemia and immune thrombocytopenic purpura[nature.com]

  • Histoplasmosis

    […] constitutional symptoms, namely weight loss and Karnofsky classification 30, gastrointestinal manifestations with alteration of liver enzymes and hepatosplenomegaly and/or splenomegaly[ncbi.nlm.nih.gov] Thrombocytopenic Purpura, and the Infection That Binds Them Together: Disseminated Histoplasmosis. ( 29276711 ) Sethi P....Moorman J. 2017 43 Correlation of CD4 counts with[malacards.org] Common clinical manifestations were fever (84%), weight loss (88%), anemia (63%), jaundice (16%), hepatomegaly (38%), splenomegaly (18%), lymphadenopathy (41%), and molluscum-like[ncbi.nlm.nih.gov]

  • Autoimmune Lymphoproliferative Syndrome

    We conclude that in selected patients with marked splenomegaly and ALPS, splenectomy may be considered a treatment option.[ncbi.nlm.nih.gov] thrombocytopenic purpura refractory to standard therapy.[ncbi.nlm.nih.gov] All five children had splenomegaly, cytopenias, and hypertriglyceridemia at presentation; four had lymphadenopathy.[ncbi.nlm.nih.gov]

  • Hairy Cell Leukemia

    Also these cytokines may play a role in the development of hairy cell leukemia.Key words: hairy cell leukemia -  sarcoidosis - massive splenomegaly.[ncbi.nlm.nih.gov] Severe immune thrombocytopenic purpura and hemolytic anaemia in a hairy-cell leukaemia patient . Eur J Haematol 1995; 54 : 127–129. 7.[nature.com] It typically affects middle-aged to elderly male who present with pancytopenia and massive splenomegaly. Lymphadenopathy is usually not seen.[ncbi.nlm.nih.gov]

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