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5,951 Possible Causes for immunity, leukocyte, mediated, of, upregulation

  • Acute Inflammation

    […] roles of eosinophils and eosinophil-derived lipid mediators in controlling acute inflammation and resolution.[ncbi.nlm.nih.gov] Here, we report that miR-466l was temporally regulated in murine exudate-infiltrating leukocytes.[ncbi.nlm.nih.gov] In contrast, serum α-Klotho levels were upregulated at peak infection (peak infection: 526 4 pg/ml, postinfection: 447 4 pg/ml, P 0·001).[ncbi.nlm.nih.gov] Provided the antigen is cleared and the immune system of the host is fully functional, the acute inflammatory response will resolve.[ncbi.nlm.nih.gov] Abstract There is an increasing need to understand the leukocytes and soluble mediators that drive acute inflammation and bring about its resolution in humans.[ncbi.nlm.nih.gov]

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  • Influenza

    Abstract Immune-mediated necrotizing myopathy is a very rare inflammatory disease affecting skeletal muscles.[ncbi.nlm.nih.gov] Histopathologic examination and enumeration of polymorphonuclear leukocytes in the nasal mucosa during experimental rhinovirus colds.[doi.org] No significant upregulation was observed in either group of guinea pigs for TNFα, TBK1, IRF5, or IFNγ ( Figure 5 ).[doi.org] Immune thrombocytopenia (ITP) is an isolated autoimmune condition, often preceded by a viral infection.[ncbi.nlm.nih.gov] […] characteristics during presentation, follow-up, and outcome, including upper or lower respiratory tract infection symptoms, intubation, antiviral therapy, viral clearance, leukocyte[doi.org]

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  • Immune Complex–Mediated Small Vessel Vasculitis

    91 Immune Complex–Mediated Small Vessel Vasculitis Key Points Vasculitis mediated by immune complexes (ICs) includes a heterogeneous group of disorders linked by inefficient[musculoskeletalkey.com] TNF-α, released due to local or systemic infection cause upregulation of endothelial adhesion molecules (e.g. selectins, ICAM-1, and VCAM) and prime the neutrophil.[karger.com] […] immune complexes ( antigen - antibody complexes) that have not been adequately cleared by innate immune cells , giving rise to an inflammatory response and attraction of leukocytes[en.wikipedia.org] The leukocytes that are drawn in by the chemotactic factors are activated by engagement of their C3b and Fc receptors by the immune complexes.[humpath.com] Although AECAs are a focus of debate and may represent an epiphenomenon, these autoantibodies are thought to activate endothelial cells, leading to (among other things) upregulation[arthritis-research.biomedcentral.com]

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  • Inflammation

    Serhan Annual Review of Immunology The Role of Cell-Mediated Immune Responses in Resistance to Malaria, with Special Reference to Oxidant Stress Anthony C.[doi.org] , 'psoriasis 1' downregulated the expression levels of NF‑κB, phosphorylated (p)‑NF‑κB, IKK, p‑IKK, STAT3, p‑STAT3, STAT4 and p‑STAT4, and upregulated the expression level[ncbi.nlm.nih.gov] HIV-infection is associated with ongoing activation of the immune system and persistent inflammation.[ncbi.nlm.nih.gov] The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets[ncbi.nlm.nih.gov] , which may play a regulatory role in mitochondrial ROS formation during fungal protease-mediated epithelial inflammation.[ncbi.nlm.nih.gov]

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  • Infectious Mononucleosis

    CASE CHARACTERISTICS: A 17-year-old boy with Epstein-Barr virus related infectious mononucleosis and cold antibody-mediated autoimmune hemolytic anemia with incidentally noted[ncbi.nlm.nih.gov] Binding of gp350 to CD21 activates several pathways, in particular NF-κB, which results in interleukin-6 (IL-6) upregulation ( 6 , 45 ).[dx.doi.org] KEYWORDS: acute infection; anti-viral immunity; cytokines; dendritic cells; herpesvirus; immune dysregulation; immune regulation; virus[ncbi.nlm.nih.gov] ABSTRACT Cultures were initiated with peripheral leukocytes from individuals: (i) in the acute stage of infectious mononucleosis (IM); (ii) with past histories of IM; and[jvi.asm.org] Corticosteroids may have a role in hastening resolution of some complications, especially upper airway obstruction and possibly immune-mediated anemia and thrombocytopenia[doi.org]

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  • Urinary Tract Infection

    Thus, these glycoside antagonists of FmlH represent a rational antivirulence strategy for UPEC-mediated UTI treatment. Copyright 2018 the Author(s). Published by PNAS.[ncbi.nlm.nih.gov] However, leukocyte response of recipients to lipopolysaccharide was impaired irrespective of donor and recipient sex to the same extend.[ncbi.nlm.nih.gov] We report here that UPEC upregulates the expression of ethanolamine utilization genes during uncomplicated UTIs in humans.[ncbi.nlm.nih.gov] Immunity 38 , 349–359 (2013).[doi.org] RESULTS: Following examination, significant laboratory data were collected including increased leukocyte count (10,800/ul with 86% neutrophils) and C-reactive protein (9.6[ncbi.nlm.nih.gov]

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  • Autoimmune Inner Ear Disease

    Immune-mediated inner ear disease is not a uniform disease with simple diagnosis or treatment.[ncbi.nlm.nih.gov] Interleukin – any of a class of glycoproteins produced by leukocytes for regulating immune responses.[brendamueller.com] Biologic Response ModifiersQuinolone-Induced Upregulation of Osteopontin Gene Promoter Activity in Human Lung Epithelial Cell Line A549. Antimicrob.[oatext.com] […] arthritis and other autoimmune diseases; Anti-nuclear antibody titer, to check for lupus and other autoimmune diseases; quantitative immunoglobulin determination; and A leukocyte[asha.org] May be associated with disturbances of balance as well as hearing loss because the inner ear mediates vestibular function as well as hearing.[accessmedicine.mhmedical.com]

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  • Sinusitis

    Mediation of contributing factors above, including second hand smoke, can reduce the likelihood of developing bacterial sinusitis.[clinicaladvisor.com] Certain human leukocyte antigens (HLA), such as HLA‐DR7, have been associated with an increased susceptibility to developing nasal polyps ( Molnar‐Gabor 2000 ).[doi.org] […] significantly during PA challenge, but protein levels are downregulated 4 hours postchallenge and upregulated at 12 hours.[ncbi.nlm.nih.gov] To the authors' knowledge, this is the first report of aseptic sinusitis as a consequence of immune checkpoint inhibition therapy.[ncbi.nlm.nih.gov] ; Varonen 2003 ) took laboratory samples: two of them ( Kaiser 2001 ; Varonen 2003 ) obtained nasopharyngeal secretions for culture and one ( Bucher 2003 ) measured CRP, leukocytes[doi.org]

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  • Leukocyte Adhesion Deficiency Syndrome

    Our results suggest looking for a possible kindlin-3 involvement in membrane dynamical event independent of integrin-mediated adhesion.[ncbi.nlm.nih.gov] Recently, it has been shown that in vivo administration of interferon gamma (IFN-gamma) upregulates CD18 expression in normals and alters leukocyte trafficking.[clinicaltrials.gov] In view of the important role of selectins in lymphocyte migration and homing, we have explored the in vivo immune responsiveness and lymphocyte recruitment to the skin, in[academic.oup.com] Abstract Important insights into the molecular basis of leukocyte emigration have come from studies of the leukocyte adhesion deficiency (LAD) syndrome, a rare heritable disorder[ncbi.nlm.nih.gov] Talin-1 and kindlin-3 regulate alpha4beta1 integrin-mediated adhesion stabilization, but not G protein-coupled receptor-induced affinity upregulation.[ncbi.nlm.nih.gov]

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  • Renal Transplant Rejection

    This systematic review evaluates the evidence for its use in the treatment of acute and chronic antibody-mediated renal transplant rejection (AAMR; CAMR).[ncbi.nlm.nih.gov] Chemokines attract leukocytes bearing specific chemokine receptors, and the specific leukocyte chemokine receptor phenotype is associated with types of immune responses, ie[ncbi.nlm.nih.gov] Human kidney epithelial cells were cultured and TACE plasmid was transfected to upregulate TACE expression.[ncbi.nlm.nih.gov] […] tolerance in allograft recipients and immune rejection in RCC patients.[ncbi.nlm.nih.gov] The Food and Drug Administration (FDA) is announcing a public workshop regarding new developments and scientific issues related to antibody mediated rejection (AMR) in kidney[fda.gov]

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