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356 Possible Causes for Immunodeficiency Is Progressive, Leukocytosis, Splenomegaly

  • Infectious Mononucleosis

    Clinical estimates of splenomegaly are fallible.[ncbi.nlm.nih.gov] Sprunt, Frank Alexander Evans (1889-1956): Mononuclear leukocytosis in reaction to acute infection (infectious mononucleosis).[whonamedit.com] A major obstacle to understanding these sequelae has been the lack of an efficient animal model for EBV infection, although progress in primate and mouse models has recently[ncbi.nlm.nih.gov]

  • Adult-Onset Still Disease

    […] clinically by high spiking fever, polyarthralgia/arthritis, a salmon-pink evanescent rash, predominantly neutrophilic leucocytosis, lymphadenopathy, liver dysfunction, and splenomegaly[ncbi.nlm.nih.gov] Collapsing glomerulopathy is a new pattern of renal disease that emerged with the human immunodeficiency virus (HIV) epidemic in the 1970s—HIV-associated nephropathy.[rheumatology.oxfordjournals.org] AOSD) is a systemic inflammatory disease characterized by high-fevers, articular involvement, maculopapular rash, hepatosplenomegaly, lymphadenopathy, and a neutrophilic leukocytosis[ncbi.nlm.nih.gov]

  • Chronic Myeloid Leukemia

    Three of 4 TKI-treated patients did not reach complete hematologic response due to the persistence of thrombocytosis and/or splenomegaly.[ncbi.nlm.nih.gov] According to some investigators there is a reservoir of primitive progenitors that are capable of self-renewal or progression in vitro or in vivo in immunodeficient mice.[intechopen.com] Her disease was managed during pregnancy using interferon-α alone despite persistent leukocytosis.[ncbi.nlm.nih.gov]

  • Chronic Phase of Chronic Myeloid Leukemia

    Those complaints are generally associated with anemia and splenomegaly.[symptoma.com] According to some investigators there is a reservoir of primitive progenitors that are capable of self-renewal or progression in vitro or in vivo in immunodeficient mice.[intechopen.com] […] and hypercellular marrow Peripheral blood leukocytosis Granulocytes at all stages of maturation Two peaks: segmented neutrophils and myelocytes Basophilia Eosinophilia (frequent[surgpathcriteria.stanford.edu]

  • Familial Myelofibrosis

    Treatment Splenomegaly and extramedullary haemopoiesis Medical treatment remains the treatment of choice for most patients with symptomatic splenomegaly.[onlinelibrary.wiley.com] A correlation between leukocytosis and risk of acute leukemia has been recently reported in patients with PV. 24 These data indicate that PV patients with leukocytosis are[bloodjournal.org] Myelofibrosis refers to the progressive replacement of functional bone marrow by connective tissue.[symptoma.com]

  • Rheumatoid Arthritis

    It is extremely rare for RA to present as FS or develop after initially presenting as neutropaenia and splenomegaly.[ncbi.nlm.nih.gov] Host components which affect tumor progression. Tumor cell components which protect it from the immune system.[microbiologybook.org] Other: thyroid disorders, osteoporosis, depression, splenomegaly.[patient.info]

  • Acute Infectious Lymphocytosis

    Abdominal ultrasound may be required to assess for splenomegaly.[patient.info] Over time, these patients develop progressive immunodeficiency and if not treated, succumb to opportunistic infections, hemophagocytosis, multiorgan failure, or EBV-positive[hopkinsguides.com] Leukocytosis Leukocytosis :Significance of Monocytosis vs Lymphocytosis Monocytosis (monocyte count greater than or equal to 10x10 9 ) may indicate : - an underlying malignancy[tcd.ie]

  • Hairy Cell Leukemia

    Most patients are middle-aged to elderly adults and present with splenomegaly and pancytopenia.[icd9data.com] It usually develops In patients with an underlying immunodeficiency.[ncbi.nlm.nih.gov] The 3 HCL-v patients had leukocytosis and received chemotherapy with variable outcome.[ncbi.nlm.nih.gov]

  • Prolymphocytic Leukemia

    A 69-year-old woman was admitted to our hospital because of massive splenomegaly and leukocytosis.[ncbi.nlm.nih.gov] […] cerebellar ataxia, telangiectasias, genomic instability, immunodeficiency, 4 and cancer predisposition; 10% to 25% of patients develop malignancy, particularly T-cell neoplasms[bloodadvances.org] This patient presented with an asymptomatic leukocytosis and splenomegaly.[ncbi.nlm.nih.gov]

  • Pediatric Chronic Granulomatous Disease

    Hemophagocytic lymphohistiocytosis (HLH) is characterized by fever, cytopenias, splenomegaly, and hemophagocytosis by macrophages activated by high cytokine levels.[ncbi.nlm.nih.gov] Failure of adequate therapy for acute community-acquired pneumonia and rapid progression to respiratory failure should lead to the possibility of fungal etiology.[ncbi.nlm.nih.gov] […] nitro blue tetrazolium test (almost always positive) Clinically, patients have recurrent lymphadenitis, hepatosplenomegaly, skin rash, pulmonary edema Laboratory Anemia, leukocytosis[pathologyoutlines.com]

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