Immunoglobulin G Increased: Causes & Reasons

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Possible Causes for Immunoglobulin G Increased

Autoimmune Hepatitis

It is characterized by inflammatory liver histology, elevated transaminase level, circulating nonorgan-specific autoantibodies, and increased level of immunoglobulin G in [ncbi.nlm.nih.gov]

Elevated serum immunoglobulin G (IgG) was detected, and tests for platelet-associated IgG and anti-nuclear antibody were positive. [ncbi.nlm.nih.gov]

immunoglobulin G level. [en.wikipedia.org]

Autoimmune Hemolytic Anemia

While conventional Coombs' tests were negative, the level of red blood cell (RBC)-bound immunoglobulin G (IgG) was increased. [ncbi.nlm.nih.gov]

Changing the RBC transfusion strategy to D- increased his Hb level to 6.7 g/dL on Day 10. [ncbi.nlm.nih.gov]

Definitions Treatment response was defined as at least a 1.5 g/dL increase of hemoglobin concentration (Hb) together with a 50% reduction of absolute reticulocyte count, observed [doi.org]

Serum Sickness

Levels of circulating immune complexes immunoglobulin G and immunoglobulin M were increased. Hypocomplementemia could not be demonstrated. [ncbi.nlm.nih.gov]

Laboratory investigation showed an increase of serum creatinine, hematuria, and proteinuria. [ncbi.nlm.nih.gov]

Sickle Cell Anemia

Sickle RBCs have increased immunoglobulin G (IgG) on the cell surface. [emedicine.com]

Hashimoto Thyroiditis

Electromicroscopy shows deposits of immunoglobulin (Ig) G and Tg along the basement membranes of follicular cells. Both B and T cells infiltrate the thyroid. [hormones.gr]

Increased expression of Th1-related cytokines such as IFNg, interleukin-2 and CD25 reportedly occurs in intrathyroidal T cells from patients with HT. [hormones.gr]

Nephrotic Syndrome

Immunoglobulin G (IgG)-λ type M protein was detected, and the levels of free λ chain was significantly increased. [ncbi.nlm.nih.gov]

Risk of infection may be increased in INS because of low immunoglobulin (Ig)G levels, which do not appear to be the result of urinary losses. [emedicine.com]

Immune Thrombocytopenic Purpura

Elevated serum immunoglobulin G (IgG) was detected, and tests for platelet-associated IgG and anti-nuclear antibody were positive. [ncbi.nlm.nih.gov]

Wajeeha Razaq A diagnosis of immune thrombocytopenic purpura was made in this otherwise healthy young man and he was started on intravenous immunoglobulin G (IVIG) at a dose [healio.com]

In short, idiopathic thrombocytopenic purpura is an autoimmune disorder caused by immunoglobulin G (IgG) auto-antibodies on the platelet surface. [sanevax.org]

Dysgammaglobulinemia

A [IgA] D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses D80.4 Selective deficiency of immunoglobulin M [IgM] D80.5 Immunodeficiency with increased immunoglobulin [icd10data.com]

Increased regulatory T-cell activity specific for IgM has been described. [7] The absence of IgM in the presence of normal levels of immunoglobulin G (IgG) and immunoglobulin [emedicine.medscape.com]

[…] spleen D80 Immunodeficiency with predominantly antibody defects D80.0 Hereditary hypogammaglobulinemia D80.1 Nonfamilial hypogammaglobulinemia D80.2 Selective deficiency of immunoglobulin [icd10data.com]

Necrotizing Alveolitis

Serum immunoglobulins (Ig) G and A were normal, while IgM fraction was increased (6.84 g/L; normal values 0.40-2.30 g/L). [clinicalcasereports.jacobspublishers.com]

Sjögren Syndrome

There is also evidence for increased intrathecal immunoglobulin G (IgG) synthesis. [epilepsy.com]

Systemic Lupus Erythematosus

Previously, we found increased immunoglobulin (Ig)G levels against varicella-zoster virus (VZV) in SLE patients compared to controls, while antibody levels against diphtheria [ncbi.nlm.nih.gov]

Waldenstrom Macroglobulinemia

IgM triggers the increased production of immunoglobulin G and the complement fixation (a mechanism) required for effective antibody response. [healthcentral.com]

Increased viscosity (thickness) of the blood may result in circulatory impairment, weakness, neurologic disorders, and fatigue. [healthcentral.com]

It is the first immunoglobulin the body produces when challenged by antigens and is found in circulating fluids. [healthcentral.com]

Celiac Disease

G; IgA, immunoglobulin A; AGA, anti-gliadin antibodies; EMA, endomysial antibodies; tTG, tissue transglutaminase. [dx.doi.org]

Valletta E., Fornaro M., Pecori S., Zanoni G. Selective immunoglobulin A deficiency and celiac disease: Let’s give serology a chance. J. Investig. Allergol. Clin. [ncbi.nlm.nih.gov]

Recognition of the coeliac iceberg has also contributed to increased detection of cases of coeliac disease (Fig. 1 ). 12 This concept demonstrates the clinical variability [dx.doi.org]

Infectious Mononucleosis Hepatitis

Commonly, patients and physicians equate increased EBV immunoglobulin G (IgG) VCA antibody titers with chronic infectious mononucleosis or CFS because more than 90% of the [emedicine.medscape.com]

[…] population has increased EBV IgG VCA antibodies. [emedicine.medscape.com]

Chronic Active Hepatitis B

Laboratory testing should show evidence of abnormal liver chemistry tests, increased total immunoglobulin G (IgG) or gamma-globulin levels and autoantibodies. [clinicaladvisor.com]

Heavy Chain Disease

Laboratory investigation showed normocytic anemia (blood hemoglobin, 77.0–99.0 g/L; mean corpuscular volume, 99.3–102.6 fl), increased serum lactate dehydrogenase, low serum [clinchem.aaccjnls.org]

[…] total protein (41.0 g/L) and albumin (28.0 g/L), and low serum cholinesterase. [clinchem.aaccjnls.org]

Serum immunoglobulin concentrations (determined by nephelometry on the Beckman Coulter Immage analyzer) were as follows: IgG, 5.31 g/L (reference interval, 7.0–16.0 g/L); [clinchem.aaccjnls.org]

Chronic Active Hepatitis

Laboratory testing should show evidence of abnormal liver chemistry tests, increased total immunoglobulin G (IgG) or gamma-globulin levels and autoantibodies. [clinicaladvisor.com]

Frequently, immune serum markers are present; they include autoantibodies against liver-specific and non–liver-specific antigens and increased immunoglobulin G (IgG) levels [emedicine.medscape.com]

[…] levels, primarily immunoglobulin G (IgG) Mild to moderately elevated serum bilirubin and alkaline phosphatase – In 80-90% of patients; a sharp increase in the alkaline phosphatase [emedicine.medscape.com]

Systemic Amyloidosis

In Figure 2 A, generally stable, low (< 1.5 g/dL) monoclonal immunoglobulin (M-Ig) levels are present for years before diagnosis, with a gradual increase resulting in a subsequent [doi.org]

[…] diagnostic M-Ig level of greater than 3 g/dL. [doi.org]

Primary Biliary Cirrhosis

Further lab tests ( Table I ) showed increased levels and titers of antinuclear antibodies (ANA) speckled pattern and anti-smooth muscle antibodies (immunoglobulin G [IgG] [consultant360.com]

Idiopathic Cryoglobulinemia

[…] ammopathy of U nknown S ignificance Long term: Increased risk of myeloma in 10 to 20 years (1% - 2%/ year) Follow-up evaluation: Test quantitative immunoglobulins every 1 [neuromuscular.wustl.edu]

[…] myeloma POEMS Syndrome Scleromyxedema Waldenström's macroglobulinemia : IgM Amyloid-like Neoplastic & Systemic Disorders IgG & IgA MGUS General issues MGUS: M onoclonal G [neuromuscular.wustl.edu]

Wiskott-Aldrich Syndrome

Immunologic studies reveal normal immunoglobulin G (IgG), decreased IgM, elevated IgA and IgE levels, and decreased T-cell function. [ncbi.nlm.nih.gov]

Infections usually begin in early infancy after maternal immunoglobulin G (IgG) is lost during the first 3 months of life. [emedicine.medscape.com]

Patients with WAS often have increased susceptibility to lymphoproliferative disorders (LPDs). [ncbi.nlm.nih.gov]

Third Trimester Pregnancy

OBJECTIVES: A proper implantation of trophoblastic cells and an appropriate metalloproteinases activity is required to cause disintegration of basal membranes of cells. The activity of tissue matrix metaloproteinases can be inhibited by their matrix inhibitors - TIMP-s. Survivin is a member of inhibitor of apoptosis[…] [ncbi.nlm.nih.gov]

Infectious Mononucleosis

Infectious mononucleosis is usually a self-limiting illness, but can be rarely associated with complications. A 17-year-old boy with Epstein-Barr virus related infectious mononucleosis and cold antibody-mediated autoimmune hemolytic anemia with incidentally noted multiple pulmonary nodules. Nodules regressed over the next[…] [ncbi.nlm.nih.gov]

Non-Hodgkin Lymphoma

Homepage Rare diseases Search Search for a rare disease Non-Hodgkin lymphoma Disease definition Non-Hodgkin malignant lymphomas(NHL) is a heterogeneous group of malignant tumors of the lymphoid system. ORPHA:547 Synonym(s): NHL Prevalence: 1-5 / 10 000 Inheritance: - Age of onset: Adult ICD-10: - OMIM: 605027[…] [orpha.net]

Portal Cirrhosis

Laennec's cirrhosis Specialty Gastroenterology Laennec's cirrhosis, also known as portal cirrhosis, alcoholic cirrhosis, fatty cirrhosis, or atrophic cirrhosis,[1] is named after René Laennec,[2] a French physician and the inventor of the stethoscope. It is a disease of the liver in which the normal lobular architecture[…] [en.wikipedia.org]

Rheumatoid Arthritis

Rheumatoid arthritis is a chronic systemic inflammatory disease. It may affect many tissues and organs and any joint lined by a synovial membrane may be involved. The active disease presents itself as fatigue, loss of appetite, muscle and joint pain and stiffness. The muscle pain is more prominent in the mornings[…] [symptoma.com]

Heroin Dependence

Addict Biol. 2014 Jan;19(1):111-21. doi: 10.1111/j.1369-1600.2012.00445.x. Epub 2012 Apr 13. Nelson EC 1, Lynskey MT, Heath AC, Wray N, Agrawal A, Shand FL, Henders AK, Wallace L, Todorov AA, Schrage AJ, Madden PA, Degenhardt L, Martin NG, Montgomery GW. Author information 1 Department of Psychiatry, Washington University[…] [ncbi.nlm.nih.gov]

Macronodular Cirrhosis

Hepatocellular carcinoma is rare in infancy. This report describes the first documented case of congenital hepatocellular carcinoma associated with macronodular cirrhosis. [ncbi.nlm.nih.gov]

Cryptogenic Cirrhosis

Abstract Some patients diagnosed with cryptogenic cirrhosis may have "burned-out" nonalcoholic fatty liver disease (NAFL). To test this hypothesis, we used our liver transplant database (November 1984 to November 1998) to assess the incidence of NAFL in patients with cryptogenic cirrhosis after orthotopic liver[…] [ncbi.nlm.nih.gov]

Viral Hepatitis

Abstract The commonest causes of acute pancreatitis are cholelithiasis and alcohol. Rare causes include various viral infections, among which mumps is the commonest. Hepatitis A, hepatitis B and, recently, hepatitis E have been reported to cause acute but mild pancreatitis in patients with acute viral hepatitis. This[…] [ncbi.nlm.nih.gov]