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13 Possible Causes for Immunoglobulin G Increased, Pruritus, Virus Associated Hemophagocytic Syndrome

  • Chronic Active Hepatitis

    Bone marrow biopsy showed hypocellularity, histiocytic hyperplasia, and hemophagocytosis consistent with a virus-associated hemophagocytic syndrome (VAHS).[ncbi.nlm.nih.gov] Laboratory testing should show evidence of abnormal liver chemistry tests, increased total immunoglobulin G (IgG) or gamma-globulin levels and autoantibodies.[clinicaladvisor.com] Pruritus (cholestasis). Breast swelling (gynaecomastia), testicular atrophy, loss of libido and amenorrhoea due to endocrine dysfunction.[patient.info]

  • Autoimmune Hepatitis

    Virus-, drug- and lymphoma-associated hemophagocytic syndrome (HPS) was ruled out. Therefore, the patient was diagnosed with autoimmune-associated HPS (AAHS).[ncbi.nlm.nih.gov] It is characterized by inflammatory liver histology, elevated transaminase level, circulating nonorgan-specific autoantibodies, and increased level of immunoglobulin G in[ncbi.nlm.nih.gov] Fatigue Abdominal pain Joint pain Itching (pruritus) Jaundice An enlarged liver Abnormal blood vessels on the skin (spider angiomas) Nausea and vomiting Loss of appetite Skin[columbiasurgery.org]

  • Hodgkin Lymphoma

    Hodgkin lymphoma-associated hemophagocytic syndrome: a disorder strongly correlated with Epstein-Barr virus. Clin Infect Dis. 2008 Aug 15. 47(4):531-4. [Medline].[emedicine.medscape.com] She remained with a low level of pruritus until her death in July 2008, at the same dose of thalidomide.[ncbi.nlm.nih.gov] […] weeks primigravida was referred from the Emergency Department to the Medical Unit Khyber Teaching Hospital-MTI, Peshawar with four weeks of fever, progressive jaundice, pruritus[ncbi.nlm.nih.gov]

  • Sickle Cell Disease

    Sickle RBCs have increased immunoglobulin G (IgG) on the cell surface.[emedicine.com] These include nausea, vomiting, pruritus, constipation, mental changes, tolerance, dependence, hyperalgesia, and addiction.[doi.org] […] also causes seizures with a reported prevalence of 1.2% if given in sufficiently large doses. 27 Morphine is the most histaminergic opioid 28 and is associated with severe pruritus[doi.org]

  • Infectious Mononucleosis Hepatitis

    Severe chronic active Epstein-Barr virus infection accompanied by virus-associated hemophagocytic syndrome, cerebellar ataxia and encephalitis.[emedicine.medscape.com] Symptomatic measures can include the use of simple analgesics and paracetamol to lower fever or a trial of cholestyramine in cases of intractable pruritus.[jmedicalcasereports.biomedcentral.com] Commonly, patients and physicians equate increased EBV immunoglobulin G (IgG) VCA antibody titers with chronic infectious mononucleosis or CFS because more than 90% of the[emedicine.medscape.com]

  • Erythema Multiforme

    Matsumoto YNaniwa DBanno SSugiura Y The efficacy of therapeutic plasmapheresis for the treatment of fatal hemophagocytic syndrome: two case reports.[jamanetwork.com] […] greater increase in the immunoglobulin G antibodies in paired sera tested 2 to 3 weeks apart can confirm the diagnosis.[clinicaladvisor.com] Abstract A 49-year old woman was hospitalized for generalized rash and pruritus following the administration of ophthalmic drops containing ciprofloxacin to treat conjunctivitis[ncbi.nlm.nih.gov]

  • Hepatosplenomegaly

    T-cell lymphoma and the virus-associated hemophagocytic syndrome. Am J Clin Pathol. 1991; 97 :189–194. [ PubMed ] 16.[ncbi.nlm.nih.gov] Relapses of thrombocytopenia with increases of platelet-associated immunoglobulin G and hepatosplenomegaly have been observed approximately every 2 months, and two relapses[ncbi.nlm.nih.gov] Amyloidosis may be associated not only with Hepatolienal syndrome, but also, more rarely, with the advent of cholestatic jaundice and pruritus,.[authorstream.com]

  • Hydroa Vacciniforme-Like Lymphoma

    In contrast out of 11 severe patients in this study, 6 had evidence of chronic EBV infection, 5 had hypersensitivity to mosquito bites, 4 had virus-associated hemophagocytic[en.wikipedia.org] Blood analysis revealed increased levels of EBV DNA (6,000 copies/ml) and the presence of immunoglobulin G (IgG) antibodies against EBV antigens (EBNA-1, VCA p18, VCA p23,[medicaljournals.se] The thickening, scaling, peeling and pruritus of the skin can be intense.[rarediseases.org]

  • Hepatitis A

    hemophagocytic syndrome [3].[ncbi.nlm.nih.gov] […] serum immunoglobulin G levels, presence of other diseases with autoimmune features Systemic lupus erythematosus Systemic autoimmune disease is predominant; abdominal pain[web.archive.org] Here we present a case of a 36-year-old female patient who developed severe pruritus and jaundice three weeks after initially uncomplicated hepatitis A.[ncbi.nlm.nih.gov]

  • Infectious Mononucleiosis Encephalitis

    Severe chronic active Epstein-Barr virus infection accompanied by virus-associated hemophagocytic syndrome, cerebellar ataxia and encephalitis.[emedicine.medscape.com] Commonly, patients and physicians equate increased EBV immunoglobulin G (IgG) VCA antibody titers with chronic infectious mononucleosis or CFS because more than 90% of the[emedicine.medscape.com] Maculopapular rashes associated with pruritus are not caused by infectious agents.[emedicine.medscape.com]

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